Organic NIR‐II Nanofluorophore with Ultrahigh Quantum Yield for Vessels Imaging and Fluorescence Image‐Guided Surgery DOI
Xinyi Zhang, Ling Li, Yuxin Ren

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 7, 2024

Abstract The second near‐infrared window (NIR‐II) fluorescence imaging has aroused more and interest in biomedical applications due to negligible autofluorescence deep penetration ability. However, the quantum yield of NIR‐II fluorophores with than 1100 nm emission wavelength is typically less 1%, thus limiting quality tissues. In this study, a novel organic small molecule CTB1125 designed synthesized. Due an efficient intramolecular charge transfer (ICT) facilitated by high donor‐acceptor‐donor (D‐A‐D) strength structure, exhibits maximum 1125 nm. Additionally, branched alkyl chains are modified on conjugated fused ring backbone reduce intermolecular stacking. encapsulated amphiphilic copolymer PS 2000 ‐PEG form CTB1125‐NPs, which exhibit ultrahigh up 4.84% aqueous solution, excellent photostability, signal‐to‐noise rate. these outstanding properties, CTB1125‐NPs have been successfully used for clear long‐duration vessel amounts low laser power short exposure time, precisely guiding surgical resection tumors mice through imaging. This work provides promising fluorophore brightness deep‐tissue imaging‐guided surgery.

Язык: Английский

Combating chemoresistance: Current approaches & nanocarrier mediated targeted delivery DOI
Siuli Shaw, Subrata K. Pore,

D.-M. Liu

и другие.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2025, Номер unknown, С. 189261 - 189261

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
The Role and Mechanism of Innate Immune Regulation in Overcoming Oxaliplatin Resistance and Enhancing Anti-Tumor Efficacy in Colorectal Cancer DOI Creative Commons

Xiaoqing Wang,

Meili Xi, Xing Lü

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(3), С. 317 - 317

Опубликована: Фев. 24, 2025

Background/Objectives: The reversal effect of cGAMP, as a STING pathway regulator, on oxaliplatin resistance in colorectal cancer was investigated, and its mechanism proposed. Methods: efficacy the cGAMP combination for oxaliplatin-resistant through nude mouse tumor model were investigated analyzed, western blot analysis tumors applied. Results: After OXA treatment, IC50 values HCT116 HCT116/L cells 9.04 μmol/L 47.04 μmol/L, respectively. In models, significantly reversed to primary drug-resistant cancer, inhibition rate increased from 8% (oxaliplatin alone) 60% (combination). transplanted model, combined treatment also showed more significant than alone, by 39%, indicating that had considerable improvement acquired resistance. These results fully demonstrated synergistic oxaliplatin. Western enhanced sensitivity down-regulating expression p-PI3K p-AKT up-regulating p53 protein. Conclusions: an immunomodulator against resistance, shows potential application prospect treating cancer.

Язык: Английский

Процитировано

0
Advances in polymer nanomaterials targeting cGAS-STING pathway for enhanced cancer immunotherapy DOI
Shiyu Peng,

Xiaoxue Hou,

Jianfeng Liu

и другие.

Journal of Controlled Release, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Bifunctional Metal‐Organic Framework Synergistically Enhances Radiotherapy and Activates STING for Potent Cancer Radio‐Immunotherapy DOI Creative Commons
Chaoyu Wang, Jinhong Li, Xiaomin Jiang

и другие.

Angewandte Chemie, Год журнала: 2024, Номер unknown

Опубликована: Окт. 8, 2024

Abstract The activation of the stimulator interferon genes (STING) protein by cyclic dinucleotide metabolites plays a critical role in antitumor immunity. However, synthetic STING agonists like 4‐(5,6‐dimethoxybenzo[b]thiophen‐2‐yl)‐4‐oxobutanoic acid (MSA‐2) exhibit suboptimal pharmacokinetics and fail to sustain tumors for effective responses. Here, we report design MOF/MSA‐2, bifunctional MSA‐2 conjugated nanoscale metal–organic framework (MOF) based on Hf 6 secondary building units (SBUs) hexakis(4′‐carboxy[1,1′‐biphenyl]‐4‐yl)benzene bridging ligands, potent cancer radio‐immunotherapy. By leveraging high‐Z properties SBUs, MOF enhances therapeutic effect X‐ray radiation elicits immune stimulation tumor microenvironment. MOF/MSA‐2 further radiotherapeutic effects X‐rays enabling sustained promoting infiltration cells tumors. plus low‐dose irradiation strong regression, when combined with an checkpoint inhibitor, effectively suppresses both primary distant through systemic activation.

Язык: Английский

Процитировано

0
Bifunctional Metal‐Organic Framework Synergistically Enhances Radiotherapy and Activates STING for Potent Cancer Radio‐Immunotherapy DOI Creative Commons
Chaoyu Wang, Jinhong Li, Xiaomin Jiang

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер unknown

Опубликована: Окт. 8, 2024

Abstract The activation of the stimulator interferon genes (STING) protein by cyclic dinucleotide metabolites plays a critical role in antitumor immunity. However, synthetic STING agonists like 4‐(5,6‐dimethoxybenzo[b]thiophen‐2‐yl)‐4‐oxobutanoic acid (MSA‐2) exhibit suboptimal pharmacokinetics and fail to sustain tumors for effective responses. Here, we report design MOF/MSA‐2, bifunctional MSA‐2 conjugated nanoscale metal–organic framework (MOF) based on Hf 6 secondary building units (SBUs) hexakis(4′‐carboxy[1,1′‐biphenyl]‐4‐yl)benzene bridging ligands, potent cancer radio‐immunotherapy. By leveraging high‐Z properties SBUs, MOF enhances therapeutic effect X‐ray radiation elicits immune stimulation tumor microenvironment. MOF/MSA‐2 further radiotherapeutic effects X‐rays enabling sustained promoting infiltration cells tumors. plus low‐dose irradiation strong regression, when combined with an checkpoint inhibitor, effectively suppresses both primary distant through systemic activation.

Язык: Английский

Процитировано

0
Motor‐Cargo Structured Nanotractors for Augmented NIR Phototherapy via Gas‐Boosted Tumor Penetration and Respiration‐Impaired Mitochondrial Dysfunction DOI Open Access
Jing Wang, Yi Zhang, Huadong Chen

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 8, 2024

Tumor microenvironment, characterized by dense extracellular matrix and severe hypoxia, has caused pronounced resistance to photodynamic therapy (PDT). Herein, it designed an artificial nitric oxide (NO) nanotractor with a unique "motor-cargo" structure, where photoswitching upconversion nanoparticle (UCNP) core serves as the optical engine harvest NIR light asymmetrically coated mesoporous silica (SiO

Язык: Английский

Процитировано

0
An immunostimulatory liponanogel reveals immune activation-enhanced drug delivery and therapeutic efficacy in cancer DOI
Xinyan Li,

Chengcheng Wu,

Junyao Li

и другие.

Journal of Controlled Release, Год журнала: 2024, Номер 376, С. 167 - 183

Опубликована: Окт. 11, 2024

Язык: Английский

Процитировано

0
Organic NIR‐II Nanofluorophore with Ultrahigh Quantum Yield for Vessels Imaging and Fluorescence Image‐Guided Surgery DOI
Xinyi Zhang, Ling Li, Yuxin Ren

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 7, 2024

Abstract The second near‐infrared window (NIR‐II) fluorescence imaging has aroused more and interest in biomedical applications due to negligible autofluorescence deep penetration ability. However, the quantum yield of NIR‐II fluorophores with than 1100 nm emission wavelength is typically less 1%, thus limiting quality tissues. In this study, a novel organic small molecule CTB1125 designed synthesized. Due an efficient intramolecular charge transfer (ICT) facilitated by high donor‐acceptor‐donor (D‐A‐D) strength structure, exhibits maximum 1125 nm. Additionally, branched alkyl chains are modified on conjugated fused ring backbone reduce intermolecular stacking. encapsulated amphiphilic copolymer PS 2000 ‐PEG form CTB1125‐NPs, which exhibit ultrahigh up 4.84% aqueous solution, excellent photostability, signal‐to‐noise rate. these outstanding properties, CTB1125‐NPs have been successfully used for clear long‐duration vessel amounts low laser power short exposure time, precisely guiding surgical resection tumors mice through imaging. This work provides promising fluorophore brightness deep‐tissue imaging‐guided surgery.

Язык: Английский

Процитировано

0