Multifunctional hydrogel electronics for closed-loop antiepileptic treatment

Science Advances, Год журнала: 2024, Номер 10(47)

Опубликована: Ноя. 22, 2024

Closed-loop strategies offer advanced therapeutic potential through intelligent disease management. Here, we develop a hydrogel-based, single-component, organic electronic device for closed-loop neurotherapy. Fabricated out of conductive hydrogels, the consists flexible array microneedle electrodes, each which can be individually addressed to perform electrical recording and control chemical release with sophisticated spatiotemporal control, thus pioneering smart antiseizure system by combining pharmacological interventions. The recorded neural signal acts as trigger voltage-driven drug in detected pathological conditions predicted real-time electrophysiology analysis. When implanted into epileptic animals, enables autonomous management, where dosing antiepileptic is controlled time-sensitive, region-selective, dose-adaptive manner, allowing inhibition seizure outbursts delivery just-necessary dosages. side effects are minimized dosages three orders magnitude lower than usage approaches simulating existing clinical treatments.

Язык: Английский

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3D bioprinted dynamic bioactive living construct enhances mechanotransduction-assisted rapid neural network self-organization for spinal cord injury repair

Bioactive Materials, Год журнала: 2025, Номер 46, С. 531 - 554

Опубликована: Янв. 8, 2025

Язык: Английский

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Hydrogel-Based Innovations in Carpal Tunnel Syndrome: Bridging Pathophysiological Complexities and Translational Therapeutic Gaps

Gels, Год журнала: 2025, Номер 11(1), С. 52 - 52

Опубликована: Янв. 9, 2025

Carpal Tunnel Syndrome (CTS) is a prevalent neuropathic disorder caused by chronic compression of the median nerve, leading to sensory and motor impairments. Conventional treatments, such as corticosteroid injections, wrist splinting, surgical decompression, often fail provide adequate outcomes for or recurrent cases, emphasizing need innovative therapies. Hydrogels, highly biocompatible three-dimensional biomaterials with customizable properties, hold significant potential CTS management. Their ability mimic extracellular matrix facilitates localized drug delivery, anti-adhesion barrier formation, tissue regeneration. Advances in hydrogel engineering have introduced stimuli-responsive systems tailored biomechanical environment carpal tunnel, enabling sustained therapeutic release improved integration. Despite these promising developments, applications remain underexplored. Key challenges include absence CTS-specific preclinical models rigorous clinical validation. Addressing gaps could unlock full hydrogel-based interventions, which offer minimally invasive, solutions that improve long-term reduce recurrence rates. This review highlights hydrogels transformative approach therapy, advocating continued research address translational barriers. These innovations redefine treatment landscape, significantly enhancing patient care quality life.

Язык: Английский

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Designing hydrogel for application in spinal surgery

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101536 - 101536

Опубликована: Фев. 3, 2025

Язык: Английский

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Fecal microbiota transplantation promotes functional recovery in mice with spinal cord injury by modulating the spinal cord microenvironment

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 20, 2025

spinal cord injury (SCI) disrupts the gut microbiota, worsening injury's impact. Fecal microbiota transplantation (FMT) is increasingly recognized as a promising strategy to improve neural function post-SCI, yet its precise mechanisms are still far from clear. The present study aims elucidate how FMT influences motor recovery and underlying utilizing SCI mouse model. Mice with received healthy donors. We used 16 S rRNA amplicon sequencing analyze alterations of microbes. Pathological in tissue, including neuronal survival, axonal regeneration, cell proliferation, neuroinflammation, were assessed among experimental groups. Additionally, RNA (RNA-seq) was explore relevant signaling pathways. Significant shifts composition following observed through analysis. On day 7 group exhibited significantly higher diversity compared ABX group, more closely resembling that mice. promoted survival leading notable improvements control Immunofluorescence staining showed increased alleviated extracellular matrix (ECM) deposition, diminished glial scar formation, reduced inflammation FMT-treated RNA-seq analysis indicated induced transcriptomic changes associated material metabolism, ECM remodeling, anti-inflammatory responses. restored balance mice, mitigated inflammation, establishing an optimal environment for recovery. These findings demonstrated may represent valuable approach enhance functional SCI.

Язык: Английский

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Tissue‐Adaptive BSA Hydrogel with Dual Release of PTX and bFGF Promotes Spinal Cord Injury Repair via Glial Scar Inhibition and Axon Regeneration

Small, Год журнала: 2024, Номер unknown

Опубликована: Окт. 10, 2024

Spinal cord injury (SCI) is a severe clinical disease usually accompanied by activated glial scar, neuronal axon rupture, and disabled motor function. To mimic the microenvironment of SCI site, hydrogel system with comparable mechanical property to spinal desirable. Therefore, novel elastic bovine serum albumin (BSA) fabricated excellent adhesive, injectable, biocompatible properties. The used deliver paclitaxel (PTX) together basic fibroblast growth factor (bFGF) inhibit scar formation as well promote regeneration function for repair. Due specific interaction BSA both drugs, bFGF, PTX can be controllably released from achieve an effective concentration at wound site during process. Moreover, benefiting combination this bFGF/PTX@BSA significantly aided repair promoting elongation axons across reduced reactive astrocyte secretion. In addition, remarkable anti-apoptosis nerve cells evident system. Subsequently, multi-functionalized drug improved rats after SCI. These results reveal that ideal functionalized material in

Язык: Английский

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Microenvironment‐Responsive Injectable Conductive Hydrogel for Spinal Cord Injury Repair

Advanced Functional Materials, Год журнала: 2024, Номер 34(46)

Опубликована: Окт. 12, 2024

Abstract Spinal cord injury (SCI) represents a severe neurological condition often coupled with drastic secondary inflammatory response, which further exacerbates the damage in most cases. Due to their unique electrical and mechanical compatibilities spinal cord, utilization of conductive hydrogels through injection for SCI repair, particularly scenarios involving non‐uniform large gaps, has emerged as promising approach. Herein, leveraging acidic microenvironment characteristic acute sites, an injectable hydrogel pH‐responsive immunoregulation is engineered repair. Based on dynamic Schiff base chemistry covalent photo‐crosslinking, this composite hydrogel, composed gelatin methacryloyl, oxidized dextran, MoS 2 , exhibits adjustable properties, enabling customized match natural cord's attributes. Additionally, incorporation Wnt5a its selective release conditions prompt immediate suppression factors enhances neural differentiation regeneration. In 2‐mm hemisection mouse model, optimized can effectively bridge gap, establish nerve connections signal, mitigate promoted recovery mobility. This novel system offers advance therapeutic materials

Язык: Английский

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Biomimetic Multichannel Silk Nerve Conduits With Multicellular Spatiotemporal Distributions for Spinal Cord Injury Repair

Advanced Materials, Год журнала: 2024, Номер 36(44)

Опубликована: Сен. 13, 2024

Abstract Bioengineered nerve conduits have shown great promise for spinal cord injury (SCI) repair, while their practical values are limited by poor regenerative efficacy and lack of multi‐level structural design. Here, inspired the ingenious anatomy natural cords, a biomimetic multichannel silk conduit (namely BNC@MSCs/SCs) with multicellular spatiotemporal distributions effective SCI repair is presented. The (BNC) hierarchical channels aligned pore structures prepared via modified directional freeze‐casting strategy. Such provide appropriate space mesenchymal stem cells (MSCs) Schwann (SCs) settled in specific channels, which contributes to generation BNC@MSCs/SCs resembling cellular cords. vitro results reveal facilitated SC migration MSC differentiation such system, further promotes tube formation cell endothelial as well M2 polarization macrophages. Moreover, can effectively promote tissue function recovery rats attenuating glial scar promoting neuron regeneration myelin sheath reconstruction. Thus, it believed that valuable other neural regeneration.

Язык: Английский

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Anisotropic hydrogel microelectrodes for intraspinal neural recordings in vivo

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 28, 2025

Creating durable, motion-compliant neural interfaces is crucial for accessing dynamic tissues under in vivo conditions and linking activity with behaviors. Utilizing the self-alignment of nano-fillers a polymeric matrix repetitive tension, here, we introduce conductive carbon nanotubes high aspect ratios into semi-crystalline polyvinyl alcohol hydrogels, create electrically anisotropic percolation pathways through cyclic stretching. The resulting hydrogel fibers (diameter 187 ± 13 µm) exhibit fatigue resistance (up to 20,000 cycles at 20% strain) stretchability 64.5 7.9% low electrochemical impedance (33.20 9.27 kΩ @ 1 kHz cm length). We observe reconstructed nanofillers' axial alignment corresponding decrease along direction fabricate fiber-shaped hydrogels bioelectronic devices implant them wild-type transgenic Thy1::ChR2-EYFP mice record electromyographic signals from muscles anesthetized freely moving conditions. These effectively enable simultaneous recording electrical ventral spinal cord neurons tibialis anterior during optogenetic stimulation. Importantly, maintain functionality intraspinal electrophysiology recordings over eight months after implantation, demonstrating their durability potential long-term monitoring neurophysiological studies. essential Here, authors nanotube-enhanced creating anisotropic, fatigue-resistant electrophysiological mice.

Язык: Английский

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Bioelectronics with Topological Crosslinked Networks for Tactile Perception

Advanced Physics Research, Год журнала: 2025, Номер unknown

Опубликована: Фев. 4, 2025

Abstract Bioelectronics, which integrate biological systems with electronic components, have attracted significant attention in developing biomimetic materials and advanced hardware architectures to enable novel information‐processing systems, sensors, actuators. However, the rigidity of conjugated molecular lack reconfigurability static crosslinked structures pose challenges for flexible sensing applications. Topological networks (TCNs) featuring dynamic interactions offer enhanced flexibility environmentally induced reconfigurability, decoupling competition between performances. Here, recent advances are summarized assembly methods bioelectronics different TCNs elaborate ion/electron‐transport mechanisms from perspective interactions. Decoupling effects can be achieved by comparing distinct their respective properties, an outlook is provided on a new range neuromorphic biocompatibility, self‐healing, self‐powered, multimodal‐sensing capabilities. The development TCN‐based significantly impact fields artificial perception devices, networks, systems.

Язык: Английский

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