Aggressive Serous Carcinomas of the Female Reproductive Tract: Cancer-Prone Cell States and Genetic Drivers
Cancers,
Год журнала:
2025,
Номер
17(4), С. 604 - 604
Опубликована: Фев. 11, 2025
In
2025,
gynecological
cancers
are
projected
to
account
for
approximately
10%
of
cancer-related
deaths
in
women.
High-grade
serous
ovarian
carcinoma
(HGSC)
and
endometrial
(SEC)
the
most
lethal
cancer
subtypes.
Both
malignancies
commonly
have
TP53
mutations,
alterations
RB1
pathway,
numerous
secondary
mutations.
types
consist
poorly
differentiated
highly
heterogeneous
cell
populations
at
time
detection.
Latent
development
rapid
progression
HGSC
SEC
impede
identification
definitive
cells
origin
genetic
drivers.
Here,
we
review
our
current
knowledge
about
cancer-prone
states
We
also
discuss
how
emerging
transcriptomic
tools
applied
contemporary
model
systems
may
facilitate
novel
targets
timely
detection
therapeutic
intervention.
Язык: Английский
Generation of healthy bovine ovarian organoids: a proof-of-concept derivation technique
Journal of Ovarian Research,
Год журнала:
2025,
Номер
18(1)
Опубликована: Май 22, 2025
Язык: Английский
InterpolAI: deep learning-based optical flow interpolation and restoration of biomedical images for improved 3D tissue mapping
Nature Methods,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 28, 2025
Язык: Английский
Neural Organoids Protect Engineered Heart Tissues From Glucolipotoxicity by Transferring Versican in a Co‐Culture System
Baochen Bai,
Jiting Li,
Ze Wang
и другие.
Cell Proliferation,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 3, 2025
ABSTRACT
Metabolic
disorders
could
cause
dysregulated
glucose
and
lipid
at
the
systemic
level,
but
how
inter‐tissue/organ
communications
contribute
to
glucolipotoxicity
is
difficult
dissect
in
animal
models.
To
solve
this
problem,
myocardium
nerve
tissues
were
modelled
by
3D
engineered
heart
(EHTs)
neural
organoids
(NOs),
which
co‐cultured
a
generalised
medium
with
normal
or
elevated
glucose/fatty
acid
contents.
Morphology,
gene
expression,
cell
death
functional
assessments
detected
no
apparent
alterations
of
EHTs
NOs
co‐culture
under
conditions.
By
contrast,
significantly
ameliorated
EHTs.
Transcriptomic
protein
secretion
assays
identified
extracellular
matrix
versican
as
key
molecule
that
was
transferred
from
into
high‐glucose/fatty
condition.
Recombinant
treatment
sufficient
reduce
Adeno‐associated
virus‐delivered
overexpression
ameliorate
cardiac
dysfunction
murine
model
diabetic
cardiomyopathy.
These
data
provide
proof‐of‐concept
evidence
exist
organoids,
be
systemically
studied
explore
potential
pathological
mechanisms
therapeutic
strategies
for
multi‐organ
diseases
vitro.
Язык: Английский
Motile Cilia in Female and Male Reproductive Tracts and Fertility
Cells,
Год журнала:
2024,
Номер
13(23), С. 1974 - 1974
Опубликована: Ноя. 28, 2024
Motile
cilia
are
evolutionarily
conserved
organelles.
In
humans,
multiciliated
cells
(MCCs),
assembling
several
hundred
motile
on
their
apical
surface,
components
of
the
monolayer
epithelia
lining
lower
and
upper
airways,
brain
ventricles,
parts
reproductive
tracts,
fallopian
tube
uterus
in
females,
efferent
ductules
males.
The
coordinated
beating
generates
a
force
that
enables
shift
tubular
fluid,
particles,
or
along
surface
ciliated
epithelia.
Uncoordinated
altered
motion
immotility
may
result
subfertility
even
infertility.
Here,
we
summarize
current
knowledge
regarding
localization
function
MCCs
human
discuss
how
beating-generated
fluid
flow
directly
indirectly
contribute
to
processes
these
organs,
lack
improper
functioning
influence
fertility.
Язык: Английский