Immunity‐Modulating Metal‐Based Nanomaterials for Cancer Immunotherapy
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 4, 2025
Abstract
Cancer
immunotherapy,
which
leverages
the
body's
immune
system
to
combat
cancer,
offers
promise
of
lower
toxicity
and
higher
therapeutic
efficacy
compared
conventional
treatments.
However,
current
immunotherapeutic
approaches
face
significant
challenges
including
variable
patient
response,
immune‐related
adverse
events,
high
costs,
underscoring
urgent
need
for
innovative
strategies.
Metal‐based
nanomaterials
have
emerged
as
a
promising
avenue
in
cancer
immunotherapy
due
their
unique
physicochemical
properties
immune‐regulating
capabilities.
Despite
potential,
concerns
about
toxicity,
incomplete
understanding
modulation
mechanisms,
early‐stage
design
strategies
hinder
clinical
translation.
This
review
summarizes
recent
advancements
metal‐based
elucidates
mechanisms
by
they
enhance
antitumor
immunity
responses,
explores
potential
synergistic
effects
combining
multiple
metals.
We
also
discuss
key
future
perspectives
application,
aiming
provide
theoretical
foundation
development
immunotherapies
promote
broader
application
treatment.
Язык: Английский
Copper/calcium co-doped carbon dots for targeted cancer therapy with dual-mode imaging and synergistic induction of cuproptosis and calcium-mediated apoptosis
Journal of Colloid and Interface Science,
Год журнала:
2025,
Номер
unknown, С. 137337 - 137337
Опубликована: Март 1, 2025
Язык: Английский
Nanomaterials‐Induced PANoptosis: A Promising Anti‐Tumor Strategy
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 19, 2024
Abstract
Malignant
tumors
pose
a
significant
threat
to
global
public
health.
Promoting
programmed
cell
death
in
cancer
cells
has
become
critical
strategy
for
treatment.
PANoptosis,
newly
discovered
form
of
regulated
death,
integrates
key
molecular
components
pyroptosis,
apoptosis,
and
necroptosis,
activating
these
three
pathways
simultaneously
achieve
synergistic
multi‐mechanistic
killing.
PANoptosis
significantly
inhibits
growth
resistance
activates
strong
anti‐tumor
immune
response,
making
tumor‐specific
induction
potential
therapeutic
strategy.
Currently,
treatment
research
related
is
focused
mainly
on
the
development
small
molecules
cytokines.
However,
approaches
still
face
limitations
terms
metabolic
stability
tumor
specificity.
The
unique
physicochemical
properties
biological
activities
nanomaterials
hold
promise
optimizing
strategies.
This
review
summarizes
concept
mechanisms
highlights
latest
applications
nanoagents
PANoptosis‐based
anti‐cancer
therapy,
discusses
challenges
future
directions
clinical
translation.
It
hoped
that
this
will
inspire
further
exploration
treatments,
providing
new
perspectives
researchers
field.
Язык: Английский
Nanotechnology-Based Strategies for Safe and Effective Immunotherapy
Molecules,
Год журнала:
2024,
Номер
29(24), С. 5855 - 5855
Опубликована: Дек. 11, 2024
Cancer
immunotherapy
using
immune
checkpoint
blockades
has
emerged
as
a
promising
therapeutic
approach.
However,
faces
challenges
such
low
response
rates
in
solid
tumors,
necessitating
strategies
to
remodel
the
immune-suppressive
tumor
microenvironment
(TME)
into
an
immune-activated
state.
One
of
primary
approaches
achieve
this
transformation
is
through
induction
immunogenic
cell
death
(ICD).
Herein,
we
discussed
maximize
ICD
nanoparticles.
In
particular,
review
highlighted
various
studies
integrating
chemotherapy,
radiation
therapy
(RT),
photodynamic
(PDT),
and
photothermal
(PTT)
with
nanoparticle-based
immunotherapy.
The
research
covered
aims
provide
valuable
insights
for
future
on
nanoparticle-assisted
Язык: Английский
Nanomaterials‐Induced PANoptosis: A Promising Anti‐Tumor Strategy
Angewandte Chemie,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 19, 2024
Abstract
Malignant
tumors
pose
a
significant
threat
to
global
public
health.
Promoting
programmed
cell
death
in
cancer
cells
has
become
critical
strategy
for
treatment.
PANoptosis,
newly
discovered
form
of
regulated
death,
integrates
key
molecular
components
pyroptosis,
apoptosis,
and
necroptosis,
activating
these
three
pathways
simultaneously
achieve
synergistic
multi‐mechanistic
killing.
PANoptosis
significantly
inhibits
growth
resistance
activates
strong
anti‐tumor
immune
response,
making
tumor‐specific
induction
potential
therapeutic
strategy.
Currently,
treatment
research
related
is
focused
mainly
on
the
development
small
molecules
cytokines.
However,
approaches
still
face
limitations
terms
metabolic
stability
tumor
specificity.
The
unique
physicochemical
properties
biological
activities
nanomaterials
hold
promise
optimizing
strategies.
This
review
summarizes
concept
mechanisms
highlights
latest
applications
nanoagents
PANoptosis‐based
anti‐cancer
therapy,
discusses
challenges
future
directions
clinical
translation.
It
hoped
that
this
will
inspire
further
exploration
treatments,
providing
new
perspectives
researchers
field.
Язык: Английский