2024 FDA TIDES (Peptides and Oligonucleotides) Harvest
Pharmaceuticals,
Год журнала:
2025,
Номер
18(3), С. 291 - 291
Опубликована: Фев. 20, 2025
In
2024,
the
FDA
approved
fifty
novel
drugs,
including
four
peptides
and
oligonucleotides
(TIDEs)
(two
pepTIDEs
two
oligonucleoTIDEs),
highlighting
their
increasing
importance
as
effective
alternatives
to
traditional
drug
classes.
TIDEs
provide
essential
therapies
for
complex
diseases,
such
genetic
disorders,
rather
than
merely
addressing
symptoms.
addition
oligonucleotide
therapeutics
various
conditions,
became
first
treatment
Rett
Syndrome
in
2023
were
also
used
treat
Niemann–Pick
disease
type
C
(NPC)
2024.
Interestingly,
among
strategies
employed
recent
approvals
enhance
stability
and/or
delivery,
prodrug
approach,
exemplified
by
palopegteriparatide
pegulicianine,
is
emerging
a
more
targeted
precise
therapeutic
strategy.
Additionally,
Enhanced
Stabilization
Chemistry
(ESC)-GalNAc
platform
has
been
expanded
hepatic
delivery
of
new
drug,
olezarsen.
Furthermore,
modifications
ribose
moiety
oligonucleotides,
3′-amino
substitution
imetelstat,
stability.
This
review
examines
TIDES
2024
based
on
chemical
structure,
medical
targets,
modes
action,
administration
routes,
common
adverse
effects.
addition,
it
highlights
how
strategy
improved
targeting
efficiency
extended
half-lives
active
drugs.
Язык: Английский
AI‐Guided Design of Antimicrobial Peptide Hydrogels for Precise Treatment of Drug‐resistant Bacterial Infections
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 30, 2025
Abstract
Traditional
biomaterial
development
lacks
systematicity
and
predictability,
posing
significant
challenges
in
addressing
the
intricate
engineering
issues
related
to
infections
with
drug‐resistant
bacteria.
The
unprecedented
ability
of
artificial
intelligence
(AI)
manage
complex
systems
offers
a
novel
paradigm
for
materials
development.
However,
no
AI
model
currently
guides
antibacterial
biomaterials
based
on
an
in‐depth
understanding
interplay
between
In
this
study,
AI‐guided
design
platform
(AMP‐hydrogel‐Designer)
is
developed
generate
biomaterials.
This
utilizes
generative
multi‐objective
constrained
optimization
thiol‐containing
high‐efficiency
antimicrobial
peptide
(AMP),
that
functionally
coupled
hydrogel
form
network
structure.
Additionally,
Cu‐modified
barium
titanate
(Cu‐BTO)
incorporated
facilitate
further
cross–linking
via
Cu
2+
/SH
coordination
produce
AI‐AMP‐hydrogel.
vitro,
AI‐AMP‐hydrogel
exhibits
>
99.99%
bactericidal
efficacy
against
Methicillin‐resistant
Staphylococcus
aureus
(MRSA)
Escherichia
coli
(
E.
coli)
.
Furthermore,
Cu‐BTO
converts
mechanical
stimulation
into
electrical
signals,
thereby
promoting
expression
growth
factors
angiogenesis.
rat
dynamic
wounds,
AI‐AMP
significantly
reduces
MRSA
load
markedly
accelerates
wound
healing.
Therefore,
strategy
innovative
solution
precisely
treat
bacterial
infections.
Язык: Английский
Biofilm-Associated Candidiasis: Pathogenesis, Prevalence, Challenges and Therapeutic Options
Pharmaceuticals,
Год журнала:
2025,
Номер
18(4), С. 460 - 460
Опубликована: Март 25, 2025
The
rising
prevalence
of
fungal
infections,
especially
those
caused
by
Candida
species,
presents
a
major
risk
to
global
health.
With
approximately
1.5
million
deaths
annually,
the
urgency
for
effective
treatment
options
has
never
been
greater.
spp.
are
leading
cause
invasive
significantly
impacting
immunocompromised
patients
and
in
healthcare
settings.
C.
albicans,
parapsilosis
emerging
species
auris
categorized
as
highly
dangerous
because
their
pathogenic
potential
increasing
drug
resistance.
This
review
comparatively
describes
formation
microbial
biofilms
both
bacterial
origin,
including
pathogens,
thereby
creating
novel
focus.
Biofilms
can
further
complicate
treatment,
these
structures
provide
enhanced
resistance
antifungal
therapies.
Traditional
agents,
polyenes,
azoles
echinocandins,
have
shown
effectiveness,
yet
development
continues
rise,
necessitating
exploration
therapeutic
approaches.
Antimicrobial
peptides
(AMPs)
such
anti-biofilm
Pom-1
Cm-p5
originally
isolated
from
snails
represent
promising
candidates
due
unique
mechanisms
action
neglectable
cytotoxicity.
article
discusses
challenges
posed
characteristics
important
role
virulence
new
like
AMPs.
Язык: Английский
Artificial intelligence in the discovery and modification of biological elements in medicinal plants
Medicinal Plant Biology,
Год журнала:
2025,
Номер
4(1), С. 0 - 0
Опубликована: Янв. 1, 2025
Язык: Английский
How Machine Learning Helps in Combating Antimicrobial Resistance: A Review of AMP Analysis and Generation Methods
Khalit Musin,
Elvina Asyanova
International Journal of Peptide Research and Therapeutics,
Год журнала:
2025,
Номер
31(4)
Опубликована: Апрель 15, 2025
Язык: Английский
Chemical Innovations of Antimicrobial Polymers for Combating Antimicrobial Resistance
ACS Biomaterials Science & Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 16, 2025
The
global
rise
of
antimicrobial
resistance
(AMR)
has
rendered
many
traditional
antibiotics
ineffective,
leading
to
an
urgent
need
for
alternative
therapeutic
strategies.
Antimicrobial
polymers,
with
their
ability
rapidly
kill
bacteria
by
disrupting
or
crossing
membranes
and/or
targeting
multiple
microbial
functions
without
inducing
resistance,
offer
a
promising
solution.
This
perspective
explores
recent
innovations
in
the
design
and
synthesis
focusing
on
chemical
motifs,
structural
derivatives,
applications
combating
systemic
topical
infections.
We
also
highlight
key
challenges
translating
these
materials
from
laboratory
research
clinical
practice,
including
issues
related
high
dose
required,
bioavailability
stability
infection
treatment,
disperse
biofilms
localized
management.
By
addressing
challenges,
polymers
could
play
crucial
role
development
next-generation
therapeutics
combat
multidrug-resistant
pathogens.
attempts
summarize
significant
insights
advanced
overcome
AMR,
offering
potential
pathways
improve
outcomes
treating
local
Язык: Английский
Engineered multi-domain lipid nanoparticles for targeted delivery
Chemical Society Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
introduces
a
four-domain
framework
to
dissect
engineered
lipid
nanoparticles
(LNPs)
rationally
and
explores
their
programmability,
in
vivo
behavior,
emerging
AI-driven
strategies
for
design,
simulation,
clinical
translation.
Язык: Английский
AI in fungal drug development: opportunities, challenges, and future outlook
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2025,
Номер
15
Опубликована: Май 21, 2025
The
application
of
artificial
intelligence
(AI)
in
fungal
drug
development
offers
innovative
strategies
to
address
the
escalating
threat
infections
and
challenge
antifungal
resistance.
This
review
evaluates
current
landscape
infections,
highlights
limitations
existing
therapies,
examines
transformative
potential
AI
discovery
development.
We
specifically
focus
on
how
can
enhance
identification
new
agents
improve
therapeutic
strategies.
Despite
numerous
opportunities
for
advancement,
significant
challenges
remain,
particularly
regarding
data
quality,
regulatory
frameworks,
complexities
associated
with
process.
aims
provide
insights
into
recent
advancements
technologies,
their
implications
future
development,
necessary
research
directions
effectively
leverage
improved
patient
outcomes.
Язык: Английский