Higher Residual and Metabolic Dysfunction-Associated Fatty Liver Disease Risk of the R-Enantiomer of Famoxadone in Mice DOI

Zeyu Hu,

Shouchun Xiao,

Jianing Yao

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 7, 2025

Famoxadone (FAM) is a widely used chiral fungicide that may contribute to metabolic dysfunction-associated fatty liver disease (MAFLD). However, the enantioselective toxicity and mechanism of action famoxadone enantiomers remain unclear. The bioaccumulation in mice was investigated, hepatotoxicity enantiomers, specifically relation MAFLD, evaluated by 12 week oral exposure Rac-FAM, R-FAM, S-FAM. R-FAM showed higher than S-FAM, which concentrations were 3.52 242.69 times S-FAM at no observed effect level (NOEL) 1/10 NOEL, respectively. found cause an increase coefficients, decrease AST/ALT ratio, enhanced expression inflammation-related genes, lipid droplet accumulation liver. In contrast, treated with exhibited significant changes quality these indicators. These results suggest R-famoxadone more likely be dominant enantiomer affecting Furthermore, important functional genes involved glucose metabolism detected. It significantly disrupted key pathways liver, including metabolism, acid synthesis, triglyceride β-oxidation. Additionally, induced severe disruptions compared research findings provide insights into terms their role promoting MAFLD development, contributing safe utilization pesticide famoxadone.

Язык: Английский

Higher Residual and Metabolic Dysfunction-Associated Fatty Liver Disease Risk of the R-Enantiomer of Famoxadone in Mice DOI

Zeyu Hu,

Shouchun Xiao,

Jianing Yao

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 7, 2025

Famoxadone (FAM) is a widely used chiral fungicide that may contribute to metabolic dysfunction-associated fatty liver disease (MAFLD). However, the enantioselective toxicity and mechanism of action famoxadone enantiomers remain unclear. The bioaccumulation in mice was investigated, hepatotoxicity enantiomers, specifically relation MAFLD, evaluated by 12 week oral exposure Rac-FAM, R-FAM, S-FAM. R-FAM showed higher than S-FAM, which concentrations were 3.52 242.69 times S-FAM at no observed effect level (NOEL) 1/10 NOEL, respectively. found cause an increase coefficients, decrease AST/ALT ratio, enhanced expression inflammation-related genes, lipid droplet accumulation liver. In contrast, treated with exhibited significant changes quality these indicators. These results suggest R-famoxadone more likely be dominant enantiomer affecting Furthermore, important functional genes involved glucose metabolism detected. It significantly disrupted key pathways liver, including metabolism, acid synthesis, triglyceride β-oxidation. Additionally, induced severe disruptions compared research findings provide insights into terms their role promoting MAFLD development, contributing safe utilization pesticide famoxadone.

Язык: Английский

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