Опубликована: Янв. 1, 2025
Язык: Английский
Gels, Год журнала: 2024, Номер 11(1), С. 16 - 16
Опубликована: Дек. 27, 2024
Alginate is an important natural biopolymer and metal ion-induced gelation one of its most significant functional properties. Alginate-based hydrogels crosslinked with ions are commonly utilized in the food, biomedical, tissue engineering, environment fields. The process alginate has been subject thorough research over last few decades. This review aims to summarize mechanisms induced by different cations (primarily including Ca2+, Ba2+, Cu2+, Sr2+, Fe2+/Fe3+, Al3+). Metal shows preferences for α-L-guluronic acid (G), β-D-mannuronic (M), GM blocks. Some can also selectively bind carboxyl groups guluronic acid. properties applications these alginate-based discussed. primary objective this provide useful information exploring practical alginate.
Язык: Английский
Процитировано
8
Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13
Опубликована: Апрель 28, 2025
Osteoporosis, a prevalent systemic metabolic bone disease, is characterized by diminished mass, microarchitectural deterioration of tissue, and heightened fragility. In osteoporotic patients, chronic progressive loss often leads to fractures and, in advanced cases, critical-sized defects. While traditional repair approaches are constrained significant limitations, the advent bioactive scaffolds has transformed therapeutic paradigm for regeneration. Among these innovations, natural polymer-based hydrogel have emerged as particularly promising solution tissue engineering, owing their superior biocompatibility, tunable biodegradation properties, exceptional ability replicate native extracellular matrix environment. This review systematically explores recent breakthroughs modification techniques applications defect repair, while critically analyzing existing clinical challenges proposing future research trajectories this rapidly evolving field.
Язык: Английский
Процитировано
1
Advanced Biology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 8, 2025
Abstract The etiology of osteoporosis is rooted in the disruption intricate equilibrium between bone formation and resorption processes. Nevertheless, conventional anti‐osteoporotic medications hormonal therapeutic regimens currently employed clinical practice are associated with a multitude adverse effects, thereby constraining their overall efficacy potential. Recently, nanomaterials have emerged as promising alternative due to minimal side efficient drug delivery, ability enhance formation, aiding restoring balance. This review delves into fundamental principles remodeling microenvironment, well current treatment approaches for osteoporosis. It subsequently explores research status nanomaterial‐based delivery systems treatment, encompassing inorganic nanomaterials, organic cell‐mimicking carriers exosomes mimics emerging therapies targeting microenvironment. Finally, discusses potential nanomedicine treating outlines future trajectory this burgeoning field. aim provide comprehensive reference application strategies therapy, fostering further advancements innovations critical area medical
Язык: Английский
Процитировано
0
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 8, 2025
Abstract The balance of antibacterial and osseointegration‐promoting properties on titanium (Ti) implants in a simple efficient manner is crucial for the management implant‐associated infections, condition that has become significant global health concern. Herein, nitric oxide (NO)‐mediated dual‐function smart coating with developed Ti implants. leverages distinct NO at high low concentrations to enable an on‐demand functional switch. Specifically, function achieved through rapid release high‐dose response infection microenvironment near‐infrared stimulation. Once resolved normal physiological conditions are restored, gradually releases low‐dose promote osseointegration. In vitro tests confirm exhibits ratio 97.84% 97.18% against methicillin‐resistant Staphylococcus aureus its biofilms, respectively, demonstrates ability activate osteoblasts. rat femoral model further certifies responsive mechanism efficiently facilitates switch between properties. Notably, use dual‐functional nonantibiotic agent, NO, significantly mitigates risk bacterial resistance.
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162378 - 162378
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Macromolecular Bioscience, Год журнала: 2025, Номер unknown
Опубликована: Апрель 24, 2025
Abstract Arthritis is a degenerative disease characterized by chronic cartilage degeneration. It affects hundreds of millions people worldwide and often has serious consequences such as joint pain swelling, limited mobility, deformity. However, conventional treatments still struggle to achieve satisfactory results. Finding more effective for arthritis remains an important clinical challenge. As hydrogels have unique 3D spatial mesh structure, significant material interaction ability, adjustable mechanical properties, good biodegradability, they can provide suitable cellular or tissue microenvironment, their potential in scaffolding effect, lubrication, anti‐inflammatory drug delivery expected be potent therapeutic approach the treatment osteoarthritis. In this review, three aspects hydrogel products osteoarthritis are comprehensively summarized discussed, namely, selection gel design, exploration cross‐linking mechanisms, mechanisms therapy osteoarthritis, focus on advantages limitations applications, which point out direction development strategy innovative field, applied research, transformation.
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Апрель 28, 2025
Abstract The repair of osteoporotic bone defects remains inadequately addressed, primarily due to a disruption in homeostasis, characterized by insufficient formation and excessive resorption. Current research either focuses on promoting or inhibiting resorption, however, the efficacy these single‐target therapeutic strategies is limited. Herein, “two‐way regulation” homeostasis strategy proposed utilizing piezoelectric composite membranes (DAT/KS), capable simultaneously regulating osteogenesis osteoclastogenesis, with high performance, good biocompatibility, excellent degradability, promote regeneration under conditions. DAT/KS membrane ultrasound (US) treatment enables controlled modulation stimulation release saikosaponin D (SSD), which promotes osteogenic differentiation while osteoclast function, thereby effectively restoring enhancing repair. Mechanistic insights reveal promotion both canonical non‐canonical Wnt signaling marrow mesenchymal stem cells (BMSCs), determines their fate, downregulation NF‐κB mononuclear macrophages (BMMs). This study presents optimized sono‐piezoelectric biomaterials bidirectionally osteoclastic differentiation, providing new potential approach for pathological injuries.
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Май 13, 2025
Blood vessel formation is a necessary part of bone tissue regeneration. MSCs-sEVs play vital role in the vivo regeneration strategy. However, natural suffer from limited blood potency, which makes it difficult to induce vascularized Here, sEVs derived magnesium cation-activated DPSCs (Mg2+-EVs) are purified and found have superior potential promoting endothelial cell migration angiogenesis, as well BMSC proliferation osteogenesis. The beneficial effects Mg2+-EVs could be attributed enrichment miR-451a subsequent regulation activation AKT/eNOS signaling pathways. On this basis, delivered on β-TCP-modified GelMA scaffolds for slow release better bioavailability. rat cranial defect model verifies that GelMA/β-TCP with has enhanced inducing present study provides strategy modulate cargos contents MSC-derived sEVs, obtaining desirable vascular promotion potential. Furthermore, developed delivery represent promising efficient loading slow-release clinical translation.
Язык: Английский
Процитировано
0
Carbohydrate Polymers, Год журнала: 2025, Номер unknown, С. 123809 - 123809
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Biomaterials Advances, Год журнала: 2025, Номер 176, С. 214342 - 214342
Опубликована: Май 27, 2025
Язык: Английский
Процитировано
0