Stress, Depressive Symptoms, and Physical Strength Impact Brain Perivascular Spaces: A Cohort Study with Insights from First-Degree Relatives
Abstract
Stress,
depressive
symptoms,
cardiovascular
health,
and
physical
strength
are
well-recognised
factors
that
contribute
to
microcirculatory
changes
in
the
brain.
However,
there
is
limited
understanding
of
their
impact
on
perivascular
waste
clearance.
In
this
study,
we
used
Stratifying
Depression
Resilience
Longitudinally
(STRADL)
family-based
cohort,
subgroup
Generation
Scotland
Scottish
Family
Health
Study,
assess
association
between
these
factors,
familial
influences,
space
(PVS)
characteristics.
Using
an
automated
segmentation
method
brain
magnetic
resonance
images,
generated
PVS
volumes,
count,
density
(i.e.,
count
per
unit
volume),
median
length
separate
regions.
Our
findings
indicate
burden
increases
with
age,
hypertension
current
symptoms
basal
ganglia
centrum
semiovale
regions,
higher
hair
cortisol
levels
weaker
hand
grip
only
semiovale.
Regional
differences
characteristics
observed
could
provide
insights
into
underlying
pathophysiology
PVS.
Additionally,
a
component
was
identified,
keeping
genetic
influence
morphology.
These
results
highlight
multifactorial
nature
spaces
emphasize
need
for
longitudinal
studies
observe
individual
long-term
health.
Research Square (Research Square), Год журнала: 2025, Номер unknown
Опубликована: Июнь 4, 2025
Язык: Английский