Stress, Depressive Symptoms, and Physical Strength Impact Brain Perivascular Spaces: A Cohort Study with Insights from First-Degree Relatives DOI

Maria Valdés Hernández,

Alexandra Morozova, Roberto Duarte Coello

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Июнь 4, 2025

Abstract Stress, depressive symptoms, cardiovascular health, and physical strength are well-recognised factors that contribute to microcirculatory changes in the brain. However, there is limited understanding of their impact on perivascular waste clearance. In this study, we used Stratifying Depression Resilience Longitudinally (STRADL) family-based cohort, subgroup Generation Scotland Scottish Family Health Study, assess association between these factors, familial influences, space (PVS) characteristics. Using an automated segmentation method brain magnetic resonance images, generated PVS volumes, count, density (i.e., count per unit volume), median length separate regions. Our findings indicate burden increases with age, hypertension current symptoms basal ganglia centrum semiovale regions, higher hair cortisol levels weaker hand grip only semiovale. Regional differences characteristics observed could provide insights into underlying pathophysiology PVS. Additionally, a component was identified, keeping genetic influence morphology. These results highlight multifactorial nature spaces emphasize need for longitudinal studies observe individual long-term health.

Язык: Английский

Stress, Depressive Symptoms, and Physical Strength Impact Brain Perivascular Spaces: A Cohort Study with Insights from First-Degree Relatives DOI

Maria Valdés Hernández,

Alexandra Morozova, Roberto Duarte Coello

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Июнь 4, 2025

Abstract Stress, depressive symptoms, cardiovascular health, and physical strength are well-recognised factors that contribute to microcirculatory changes in the brain. However, there is limited understanding of their impact on perivascular waste clearance. In this study, we used Stratifying Depression Resilience Longitudinally (STRADL) family-based cohort, subgroup Generation Scotland Scottish Family Health Study, assess association between these factors, familial influences, space (PVS) characteristics. Using an automated segmentation method brain magnetic resonance images, generated PVS volumes, count, density (i.e., count per unit volume), median length separate regions. Our findings indicate burden increases with age, hypertension current symptoms basal ganglia centrum semiovale regions, higher hair cortisol levels weaker hand grip only semiovale. Regional differences characteristics observed could provide insights into underlying pathophysiology PVS. Additionally, a component was identified, keeping genetic influence morphology. These results highlight multifactorial nature spaces emphasize need for longitudinal studies observe individual long-term health.

Язык: Английский

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