Current Opinion in Neurobiology, Год журнала: 2025, Номер 93, С. 103032 - 103032
Опубликована: Май 1, 2025
Drugs of abuse result in well-characterized changes synapse function and number brain reward regions such as the nucleus accumbens. However, recent reports demonstrate that only a small fraction neurons accumbens are activated response to psychostimulants cocaine. While these "ensemble" marked by drug-related transcriptional immediate early genes, mechanisms ultimately link enduring molecular alterations same less clear. In this review, we 1) describe potential underlying regulation diverse plasticity-related gene programs across drug-activated ensembles, 2) discuss factors conferring ensemble recruitment bias within seemingly homogeneous populations, 3) speculate on role chromatin epigenetic modifiers gating metaplastic state transitions contribute addiction.
Язык: Английский