Control of MAIT cell functions by cytokines in health and disease DOI Creative Commons

Laetitia Camard,

Elisabetta Bianchi, Lars Rogge

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Май 30, 2025

Mucosal-associated invariant T (MAIT) cells are innate-like that express a semi-invariant cell receptor (TCR). These predominantly reside in tissues, such as the liver, lung, skin and gastrointestinal tract. MAIT can be activated via their TCR recognizes riboflavin metabolites presented by MHC class I-related protein 1 (MR1). also TCR-independent manner cytokines, particular IL-12 IL-18, but type I interferons, IL-7, IL-15 IL-23, underlining characteristics. have important functions antibacterial viral immunity tissue repair homeostasis. Recent studies highlighted plasticity of response to suggesting an role cytokine milieu modulating functions. Here, we discuss how cytokines control various contexts.

Язык: Английский

Synergistic Photothermal-Ice Inhibition Strategy for Scalable Cryopreservation of Macroscopic Spheroids and Immune Cells in Advanced Immunotherapy DOI

Mengyao Song,

Dan He,

Hongfeng Zhou

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
MAIT cells exacerbate colonic inflammation in a genetically diverse murine model of spontaneous colitis DOI Creative Commons
Liyen Loh, David J. Orlicky,

Andrea Spengler

и другие.

Mucosal Immunology, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

IL-17-producing lymphocytes are involved in both tissue repair and the propagation of inflammation, with their effects highly context-dependent. Mucosal-Associated-Invariant-T-cells (MAIT), a subset innate-like T cells features Th1 Th17 lineages, increasingly recognized for roles mucosal immunity. Here, we identified Collaborative-Cross CC011/Unc strain, which spontaneously develops chronic colitis, as being enriched MAIT cells. This expansion coincides an age-related loss intestinal barrier permeability colonic inflammation. Microbiota from CC011 mice activated MR1-dependent manner selectively promoted accumulation MAIT17 peripheral tissues. Single-cell transcriptomic analyses revealed colon colitic expressed pathogenic Th17-like signature, characterized by IL-1 IL-23 signaling, IL-17A IFNγ co-expression, upregulation IL-23R, that correlated inflammatory Ly6Chi monocyte abundance. Genetic deletion Traj33, essential development, significantly reduced inflammation this model. These findings demonstrate integrate microbial cytokine cues to adopt effector phenotype exacerbates

Язык: Английский

Процитировано

0
Control of MAIT cell functions by cytokines in health and disease DOI Creative Commons

Laetitia Camard,

Elisabetta Bianchi, Lars Rogge

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Май 30, 2025

Mucosal-associated invariant T (MAIT) cells are innate-like that express a semi-invariant cell receptor (TCR). These predominantly reside in tissues, such as the liver, lung, skin and gastrointestinal tract. MAIT can be activated via their TCR recognizes riboflavin metabolites presented by MHC class I-related protein 1 (MR1). also TCR-independent manner cytokines, particular IL-12 IL-18, but type I interferons, IL-7, IL-15 IL-23, underlining characteristics. have important functions antibacterial viral immunity tissue repair homeostasis. Recent studies highlighted plasticity of response to suggesting an role cytokine milieu modulating functions. Here, we discuss how cytokines control various contexts.

Язык: Английский

Процитировано

0