Molecular Psychiatry, Год журнала: 2025, Номер unknown

Опубликована: Май 23, 2025

Abstract The advent of single cell multi-omic technologies has ushered in a revolution how we study the impact three-dimensional genome organization on brain cellular composition and function. Transcriptomic epigenomic studies reveal enormous diversity that is present mammalian nervous systems, raising question, “how does this arise for what its use?” Advances field nuclear architecture have illuminated our understanding folding gives rise to dynamic gene expression programs important healthy function disease. In review highlight recent work defining neuronal identity, maturation, plasticity are shaped by architecture. We discuss newly identified genetic variations influence contribute evolution species-unique behavioral functional traits. include examples both humans model organisms which maladaptive genomic causal agent Finally, make conclusions address future perspectives (4D nucelome) research.

Язык: Английский