Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

Developmental Cell, Год журнала: 2009, Номер 17(1), С. 9 - 26

Опубликована: Июль 1, 2009

Язык: Английский

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Inflammation and Colon Cancer

Gastroenterology, Год журнала: 2010, Номер 138(6), С. 2101 - 2114.e5

Опубликована: Апрель 26, 2010

Язык: Английский

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Eicosanoids and cancer

Nature reviews. Cancer, Год журнала: 2010, Номер 10(3), С. 181 - 193

Опубликована: Фев. 19, 2010

Язык: Английский

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Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

Pharmacology & Therapeutics, Год журнала: 2014, Номер 148, С. 114 - 131

Опубликована: Ноя. 29, 2014

Язык: Английский

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G-protein-coupled receptors and cancer

Nature reviews. Cancer, Год журнала: 2007, Номер 7(2), С. 79 - 94

Опубликована: Янв. 25, 2007

Язык: Английский

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The multifaceted roles of fatty acid synthesis in cancer

Nature reviews. Cancer, Год журнала: 2016, Номер 16(11), С. 732 - 749

Опубликована: Сен. 23, 2016

Язык: Английский

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The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

Carcinogenesis, Год журнала: 2009, Номер 30(3), С. 377 - 386

Опубликована: Янв. 9, 2009

It is widely accepted that alterations to cyclooxygenase-2 (COX-2) expression and the abundance of its enzymatic product prostaglandin E 2 (PGE ) have key roles in influencing development colorectal cancer. Deregulation COX-2/PGE pathway appears affect tumorigenesis via a number distinct mechanisms: promoting tumour maintenance progression, encouraging metastatic spread, perhaps even participating initiation. Here, we review role signalling highlight ability influence hallmarks cancer—attributes defined by Hanahan Weinberg as being requisite for tumorigenesis. In addition, consider components COX–prostaglandin emerging important regulators tumorigenesis; namely, prostanoid (EP) receptors, 15-hydroxyprostaglandin dehydrogenase transporter. Finally, based on recent findings, propose model cellular adaptation hypoxic microenvironment encompasses interplay between COX-2, hypoxia-inducible factor 1 dynamic switches β-catenin function fine-tune networks meet ever-changing demands tumour.

Язык: Английский

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Inflammation and cancer: An ancient link with novel potentials

International Journal of Cancer, Год журнала: 2007, Номер 121(11), С. 2373 - 2380

Опубликована: Сен. 24, 2007

Abstract Infection and chronic inflammation contribute to about 1 in 4 of all cancer cases. Mediators the inflammatory response, e.g. , cytokines, free radicals, prostaglandins growth factors, can induce genetic epigenetic changes including point mutations tumor suppressor genes, DNA methylation post‐translational modifications, causing alterations critical pathways responsible for maintaining normal cellular homeostasis leading development progression cancer. Recent discovery an interaction between microRNAs innate immunity during has further strengthened association © 2007 Wiley‐Liss, Inc.

Язык: Английский

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Immune infiltration in human tumors: a prognostic factor that should not be ignored

Oncogene, Год журнала: 2009, Номер 29(8), С. 1093 - 1102

Опубликована: Ноя. 30, 2009

Язык: Английский

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Osteocytes, mechanosensing and Wnt signaling

Bone, Год журнала: 2008, Номер 42(4), С. 606 - 615

Опубликована: Янв. 17, 2008

Язык: Английский

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