Leukocyte Migration into Inflamed Tissues

Immunity, Год журнала: 2014, Номер 41(5), С. 694 - 707

Опубликована: Ноя. 1, 2014

Язык: Английский

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Liver inflammation and fibrosis

Journal of Clinical Investigation, Год журнала: 2017, Номер 127(1), С. 55 - 64

Опубликована: Янв. 2, 2017

Chronic liver inflammation leads to fibrosis and cirrhosis, which is the 12th leading cause of death in United States. Hepatocyte steatosis a component metabolic syndrome insulin resistance. Hepatic may be benign or progress hepatocyte injury initiation inflammation, activates immune cells. While Kupffer cells are resident macrophage liver, inflammatory such as infiltrating macrophages, T lymphocytes, neutrophils, DCs all contribute inflammation. The activate hepatic stellate cells, major source myofibroblasts liver. Here we review their crosstalk with myofibroblasts.

Язык: Английский

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Immunology in the liver — from homeostasis to disease

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2016, Номер 13(2), С. 88 - 110

Опубликована: Янв. 13, 2016

Язык: Английский

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Microglia Development and Function

Annual Review of Immunology, Год журнала: 2014, Номер 32(1), С. 367 - 402

Опубликована: Янв. 29, 2014

Proper development and function of the mammalian central nervous system (CNS) depend critically on activity parenchymal sentinels referred to as microglia. Although microglia were first described ramified brain-resident phagocytes, research conducted over past century has expanded considerably upon this narrow view ascribed many functions these dynamic CNS inhabitants. Microglia are now considered among most versatile cells in body, possessing capacity morphologically functionally adapt their ever-changing surroundings. Even a resting state, processes highly perpetually scan CNS. fact vital participants homeostasis, dysregulation can give rise neurological disease. In review, we discuss exciting developments our understanding microglial biology, from developmental origin participation homeostasis pathophysiological states such neuropsychiatric disorders, neurodegeneration, sterile injury responses, infectious diseases. We also delve into world dynamics recently uncovered using real-time imaging techniques.

Язык: Английский

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Immune surveillance by the liver

Nature Immunology, Год журнала: 2013, Номер 14(10), С. 996 - 1006

Опубликована: Сен. 18, 2013

Язык: Английский

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Neutrophil migration in infection and wound repair: going forward in reverse

Nature reviews. Immunology, Год журнала: 2016, Номер 16(6), С. 378 - 391

Опубликована: Май 27, 2016

Язык: Английский

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Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

Nature, Год журнала: 2013, Номер 498(7454), С. 371 - 375

Опубликована: Май 24, 2013

Язык: Английский

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The Neutrophil’s Role During Health and Disease

Physiological Reviews, Год журнала: 2019, Номер 99(2), С. 1223 - 1248

Опубликована: Фев. 13, 2019

Neutrophils have always been considered as uncomplicated front-line troopers of the innate immune system equipped with limited proinflammatory duties. Yet recently, role neutrophil has undergoing a rejuvenation sorts. are now complex cells capable significant array specialized functions, and an effector response, they able to regulate many processes such acute injury repair, cancer, autoimmunity, chronic inflammatory processes. Furthermore, evidence exists indicate that neutrophils also contribute adaptive immunity by aiding development specific responses or guiding subsequent response. With this revived interest in their novel it is prudent review what currently known about and, even more importantly, understand information lacking. We discuss essential features neutrophil, from its origins, lifespan, subsets, margination sequestration death neutrophil. highlight recruitment both infected injured tissues outline differences between different tissues. Finally, we examine how use mechanisms either bolster protective negatively cause pathological outcomes at locations.

Язык: Английский

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International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors

Pharmacological Reviews, Год журнала: 2013, Номер 66(1), С. 1 - 79

Опубликована: Ноя. 11, 2013

Sixteen years ago, the Nomenclature Committee of International Union Pharmacology approved a system for naming human seven-transmembrane (7TM) G protein-coupled chemokine receptors, large family leukocyte chemoattractant receptors that regulates immune development and function, in part by mediating trafficking. This was announced Pharmacological Reviews major overview first decade research this field [Murphy PM, Baggiolini M, Charo IF, Hébert CA, Horuk R, Matsushima K, Miller LH, Oppenheim JJ, Power CA (2000) Pharmacol Rev 52:145–176]. Since then, several new have been discovered, advances made others many areas, including structural biology, signal transduction mechanisms, pharmacology. New diverse roles identified infection, immunity, inflammation, development, cancer, other areas. The two drugs acting at U.S. Food Drug Administration (FDA), maraviroc targeting CCR5 immunodeficiency virus (HIV)/AIDS, plerixafor CXCR4 stem cell mobilization transplantation candidates are now undergoing pivotal clinical trials disease indications. In addition, subfamily atypical has emerged may through arrestins instead proteins to act as scavengers, microbial invertebrate soluble chemokine-binding described. Here, we review extended basic, translational, levels, an update on drug development. We also introduce nomenclature with ACKR (atypical receptor) Human Genome Committee.

Язык: Английский

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Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis

Circulation Research, Год журнала: 2018, Номер 122(2), С. 337 - 351

Опубликована: Янв. 18, 2018

Platelets, non-nucleated blood components first described over 130 years ago, are recognized as the primary cell regulating hemostasis and thrombosis. The vascular importance of platelets has been attributed to their essential role in thrombosis, mediating myocardial infarction, stroke, venous thromboembolism. Increasing knowledge on platelets' vasculature led many advances understanding not only how interact with vessel wall but also they convey changes environment other circulating cells. In addition well-described hemostatic function, active participants immune response microbial organisms foreign substances. Although incompletely understood, is a delicate balance between its pathogenic regulation thrombotic functions. Platelets mediate complex homeostasis via specific receptors granule release, RNA transfer, mitochondrial secretion that subsequently regulates infection, innate adaptive immunity.

Язык: Английский

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