Pancreatic cancer

The Lancet, Год журнала: 2016, Номер 388(10039), С. 73 - 85

Опубликована: Янв. 30, 2016

Язык: Английский

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A Landscape of Pharmacogenomic Interactions in Cancer

Cell, Год журнала: 2016, Номер 166(3), С. 740 - 754

Опубликована: Июль 1, 2016

Systematic studies of cancer genomes have provided unprecedented insights into the molecular nature cancer. Using this information to guide development and application therapies in clinic is challenging. Here, we report how cancer-driven alterations identified 11,289 tumors from 29 tissues (integrating somatic mutations, copy number alterations, DNA methylation, gene expression) can be mapped onto 1,001 molecularly annotated human cell lines correlated with sensitivity 265 drugs. We find that faithfully recapitulate oncogenic tumors, many these associate drug sensitivity/resistance, highlight importance tissue lineage mediating response. Logic-based modeling uncovers combinations sensitize drugs, while machine learning demonstrates relative different data types predicting Our analysis datasets are rich resources link genotypes cellular phenotypes identify therapeutic options for selected sub-populations.

Язык: Английский

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Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Science, Год журнала: 2015, Номер 347(6217), С. 78 - 81

Опубликована: Янв. 1, 2015

Crunching the numbers to explain cancer Why do some tissues give rise in humans a million times more frequently than others? Tomasetti and Vogelstein conclude that these differences can be explained by number of stem cell divisions. By plotting lifetime incidence various cancers against estimated normal divisions corresponding over lifetime, they found strong correlation extending five orders magnitude. This suggests random errors occurring during DNA replication cells are major contributing factor development. Remarkably, this “bad luck” component explains far greater hereditary environmental factors. Science , issue p. 78

Язык: Английский

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Drugging the undruggable RAS: Mission Possible?

Nature Reviews Drug Discovery, Год журнала: 2014, Номер 13(11), С. 828 - 851

Опубликована: Окт. 17, 2014

Язык: Английский

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Age-related mutations associated with clonal hematopoietic expansion and malignancies

Nature Medicine, Год журнала: 2014, Номер 20(12), С. 1472 - 1478

Опубликована: Окт. 19, 2014

Язык: Английский

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