Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

Redox Biology, Год журнала: 2017, Номер 14, С. 450 - 464

Опубликована: Окт. 19, 2017

Oxidative stress is known to play an important role in the pathogenesis of a number diseases. In particular, it linked etiology Alzheimer's disease (AD), age-related neurodegenerative and most common cause dementia elderly. Histopathological hallmarks AD are intracellular neurofibrillary tangles extracellular formation senile plaques composed amyloid-beta peptide (Aβ) aggregated form along with metal-ions such as copper, iron or zinc. Redox active metal ions, for example can catalyze production Reactive Oxygen Species (ROS) when bound amyloid-β (Aβ). The ROS thus produced, particular hydroxyl radical which reactive one, may contribute oxidative damage on both Aβ itself surrounding molecule (proteins, lipids, …). This review highlights existing link between AD, consequences towards molecules terms damage. addition, implication ions their interaction redox properties leading discussed, vitro vivo oxidation peptide, at molecular level.

Язык: Английский

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Defeating Alzheimer's disease and other dementias: a priority for European science and society

The Lancet Neurology, Год журнала: 2016, Номер 15(5), С. 455 - 532

Опубликована: Март 14, 2016

Язык: Английский

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New Technologies for Analysis of Extracellular Vesicles

Chemical Reviews, Год журнала: 2018, Номер 118(4), С. 1917 - 1950

Опубликована: Янв. 31, 2018

Extracellular vesicles (EVs) are diverse, nanoscale membrane actively released by cells. Similar-sized can be further classified (e.g., exosomes, microvesicles) based on their biogenesis, size, and biophysical properties. Although initially thought to cellular debris, thus under-appreciated, EVs now increasingly recognized as important vehicles of intercellular communication circulating biomarkers for disease diagnoses prognosis. Despite clinical potential, the lack sensitive preparatory analytical technologies poses a barrier translation. New platforms including molecular ones being developed address these challenges. Recent advances in field expected have far-reaching impact both basic translational studies. This article aims present comprehensive critical overview emerging EV detection applications.

Язык: Английский

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<p>Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics</p>

International Journal of Nanomedicine, Год журнала: 2019, Номер Volume 14, С. 5541 - 5554

Опубликована: Июль 1, 2019

Abstract: Currently, 47 million people live with dementia globally, and it is estimated to increase more than threefold (∼131 million) by 2050. Alzheimer's disease (AD) one of the major causative factors induce progressive dementia. AD a neurodegenerative disease, its pathogenesis has been attributed extracellular aggregates amyloid β (Aβ) plaques intracellular neurofibrillary tangles made hyperphosphorylated τ-protein in cortical limbic areas human brain. It characterized memory loss neurocognitive dysfunction. The anomalous processing APP β-secretases γ-secretases leads production Aβ 40 42 monomers, which further oligomerize aggregate into senile plaques. also intensifies through infectious agents like HIV. Additionally, during pathogenesis, presence high concentrations peptides central nervous system initiates microglial infiltration. Upon coming vicinity Aβ, microglia get activated, endocytose contribute toward their clearance via TREM2 surface receptors, simultaneously triggering innate immunoresponse against aggregation. In addition detailed report on leading AD, present review discusses current state art therapeutics diagnostics, including labeling imaging techniques employed as contrast for better visualization sensing points an urgent need nanotechnology efficient therapeutic strategy bioavailability drugs system. Keywords: beta, amyloidogenesis, precursor proteins, β-secretases, γ-secretases, tau phosphorylation

Язык: Английский

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Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

Nature Neuroscience, Год журнала: 2018, Номер 21(10), С. 1332 - 1340

Опубликована: Сен. 19, 2018

Язык: Английский

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Hallmarks of neurodegenerative diseases

Cell, Год журнала: 2023, Номер 186(4), С. 693 - 714

Опубликована: Фев. 1, 2023

Summary

Decades of research have identified genetic factors and biochemical pathways involved in neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks NDD: pathological protein aggregation, synaptic neuronal network dysfunction, aberrant proteostasis, cytoskeletal abnormalities, altered energy homeostasis, DNA RNA defects, inflammation, cell death. describe hallmarks, their biomarkers, interactions as a framework to study NDDs using holistic approach. The can serve basis defining pathogenic mechanisms, categorizing different based on primary stratifying patients within specific NDD, designing multi-targeted, personalized therapies effectively halt NDDs.

Язык: Английский

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Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

Nature Neuroscience, Год журнала: 2019, Номер 22(7), С. 1099 - 1109

Опубликована: Июнь 24, 2019

Язык: Английский

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Propagation of Tau Aggregates and Neurodegeneration

Annual Review of Neuroscience, Год журнала: 2017, Номер 40(1), С. 189 - 210

Опубликована: Июль 25, 2017

A pathway from the natively unfolded microtubule-associated protein Tau to a highly structured amyloid fibril underlies human Tauopathies. This ordered assembly causes disease and represents gain of toxic function. In recent years, evidence has accumulated suggest that inclusions form first in small number brain cells, where they propagate other regions, resulting neurodegeneration disease. Propagation pathology is often called prion-like, which refers capacity an assembled induce same abnormal conformation kind, initiating self-amplifying cascade. addition, prion-like encompasses release aggregates cells their uptake by neighboring cells. mice, intracerebral injection induces monomeric Tau, followed its spreading distant regions. Conformational differences between transgenic mouse vitro recombinant account for greater seeding potency aggregates. Short fibrils constitute major species seed-competent brains mice. The existence multiple Tauopathies with distinct morphologies led suggestion different molecular conformers (or strains) aggregated exist.

Язык: Английский

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Tau and tauopathies

Brain Research Bulletin, Год журнала: 2016, Номер 126, С. 238 - 292

Опубликована: Сен. 1, 2016

Язык: Английский

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The Synucleinopathies: Twenty Years On

Journal of Parkinson s Disease, Год журнала: 2017, Номер 7(s1), С. S51 - S69

Опубликована: Март 6, 2017

In 2017, it is two hundred years since James Parkinson provided the first complete clinical description of disease named after him, fifty introduction high-dose D,L-DOPA treatment and twenty α-synuclein aggregation came to fore. 1998, multiple system atrophy joined Parkinson's dementia with Lewy bodies as third major synucleinopathy. Here we review our work, which led identification in bodies, neurites Papp-Lantos well what has happened since. Some experiments described were carried out collaboration ML Schmidt, JQ Trojanowski VMY Lee.

Язык: Английский

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