How colonization by microbiota in early life shapes the immune system

Science, Год журнала: 2016, Номер 352(6285), С. 539 - 544

Опубликована: Апрель 28, 2016

Microbial colonization of mucosal tissues during infancy plays an instrumental role in the development and education host mammalian immune system. These early-life events can have long-standing consequences: facilitating tolerance to environmental exposures or contributing disease later life, including inflammatory bowel disease, allergy, asthma. Recent studies begun define a critical period early which disruption optimal host-commensal interactions lead persistent some cases irreversible defects training specific subsets. Here, we discuss system this “window opportunity,” when microbial has potentially impact on human health disease.

Язык: Английский

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The microbiota in adaptive immune homeostasis and disease

Nature, Год журнала: 2016, Номер 535(7610), С. 75 - 84

Опубликована: Июль 5, 2016

Язык: Английский

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Dysbiosis and the immune system

Nature reviews. Immunology, Год журнала: 2017, Номер 17(4), С. 219 - 232

Опубликована: Март 6, 2017

Язык: Английский

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Lineage tracking reveals dynamic relationships of T cells in colorectal cancer

Nature, Год журнала: 2018, Номер 564(7735), С. 268 - 272

Опубликована: Окт. 24, 2018

Язык: Английский

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Homeostatic Immunity and the Microbiota

Immunity, Год журнала: 2017, Номер 46(4), С. 562 - 576

Опубликована: Апрель 1, 2017

Язык: Английский

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A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

Nature, Год журнала: 2019, Номер 565(7741), С. 600 - 605

Опубликована: Янв. 23, 2019

Язык: Английский

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Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

European Journal of Immunology, Год журнала: 2019, Номер 49(10), С. 1457 - 1973

Опубликована: Окт. 1, 2019

These guidelines are a consensus work of considerable number members the immunology and flow cytometry community. They provide theory key practical aspects enabling immunologists to avoid common errors that often undermine immunological data. Notably, there comprehensive sections all major immune cell types with helpful Tables detailing phenotypes in murine human cells. The latest techniques applications also described, featuring examples data can be generated and, importantly, how analysed. Furthermore, tips, tricks pitfalls avoid, written peer-reviewed by leading experts field, making this an essential research companion.

Язык: Английский

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Pathophysiology of Inflammatory Bowel Diseases

New England Journal of Medicine, Год журнала: 2020, Номер 383(27), С. 2652 - 2664

Опубликована: Дек. 30, 2020

Research on IBDs has identified disrupted immune responses in the gastrointestinal mucosa and putative disruptions gut microbiome as causative agents. This work led to better therapeutic control of with use various antiinflammatory

Язык: Английский

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Regulatory T Cells and Human Disease

Annual Review of Immunology, Год журнала: 2020, Номер 38(1), С. 541 - 566

Опубликована: Фев. 4, 2020

Naturally occurring CD4+ regulatory T cells (Tregs), which specifically express the transcription factor FoxP3 in nucleus and CD25 CTLA-4 on cell surface, are a functionally distinct subpopulation actively engaged maintenance of immunological self-tolerance homeostasis. Recent studies have facilitated our understanding cellular molecular basis their generation, function, phenotypic functional stability, adaptability. It is under investigation humans how or numerical Treg anomalies, whether genetically determined environmentally induced, contribute to diseases such as autoimmune diseases. Also being addressed Tregs can be targeted control physiological pathological immune responses, for example, by depleting them enhance tumor immunity expanding treat This review discusses current immunobiology normal disease states, with perspective realization Treg-targeting therapies clinic.

Язык: Английский

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The gut microbiome: Relationships with disease and opportunities for therapy

The Journal of Experimental Medicine, Год журнала: 2018, Номер 216(1), С. 20 - 40

Опубликована: Окт. 15, 2018

Over the past decade, our view of human-associated microbes has expanded beyond that a few species toward an appreciation diverse and niche-specialized microbial communities develop in human host with chronological age. The largest reservoir exists distal gastrointestinal tract, both lumen, where facilitate primary secondary metabolism, on mucosal surfaces, they interact immune cell populations. While local microbial-driven immunomodulation gut is well described, more recent studies have demonstrated role for microbiome influencing remote organs hematopoietic function. Unsurprisingly, therefore, perturbation to composition function microbiota been associated chronic diseases ranging from inflammatory metabolic conditions neurological, cardiovascular, respiratory illnesses. Considerable effort currently focused understanding natural history development humans context health outcomes, parallel improving knowledge microbiome-host molecular interactions. These efforts ultimately aim effective approaches rehabilitate perturbed ecosystems as means restore or prevent disease. This review details modulating focus discusses strategies manipulating management prevention conditions.

Язык: Английский

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