Gut-microbiota-targeted diets modulate human immune status

Cell, Год журнала: 2021, Номер 184(16), С. 4137 - 4153.e14

Опубликована: Июль 12, 2021

Язык: Английский

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Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition

Cell Metabolism, Год журнала: 2017, Номер 26(4), С. 611 - 619.e6

Опубликована: Окт. 1, 2017

Язык: Английский

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Geography, Ethnicity or Subsistence-Specific Variations in Human Microbiome Composition and Diversity

Frontiers in Microbiology, Год журнала: 2017, Номер 8

Опубликована: Июнь 23, 2017

One of the fundamental issues in microbiome research is characterization healthy human microbiota. Recent studies have elucidated substantial divergences structure between individuals from different race and ethnicity. This review provides a comprehensive account such geography, ethnicity or life-style-specific variations at five major body habitats – Gut, Oral-cavity, Respiratory Tract, Skin Urogenital Tract (UGT). The focuses on general trend evolution - gradual transition gross compositional along with continual decrease diversity microbiome, especially gut as populations passed through three stages subsistence like foraging, rural farming industrialized urban western life. In general, hunter-gatherer highly abundant Prevotella, Proteobacteria, Spirochaetes, Clostridiales, Ruminobacter etc., while those communities are often enriched Bacteroides, Bifidobacterium Firmicutes. oral skin next most diverse among populations, respiratory tract UGT show lesser variations. Higher observed for oral-cavity group higher prevalence Haemophilus than agricultural group. case Chinese variation abundance Trabulsiella Propionibacterium. On basis published data, we characterized core microbiota set genera commonly found all irrespective their geographic locations, mode subsistence. We also identified factors responsible geography-based alterations microbiota; though it not yet clear which factor plays dominant role shaping nature nurture, host genetics his environment. Some geographical/racial been attributed to differences innate/adaptive immunity, many other cases, cultural/behavioral features diet, hygiene, parasitic load, environmental exposure etc. overshadow genetics. population-specific composition, reviewed this report, question universality microbiome-based therapeutic strategies recommend geographically tailored community-scale approaches engineering.

Язык: Английский

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Depression and obesity: evidence of shared biological mechanisms

Molecular Psychiatry, Год журнала: 2018, Номер 24(1), С. 18 - 33

Опубликована: Фев. 16, 2018

Язык: Английский

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Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome

Movement Disorders, Год журнала: 2017, Номер 32(5), С. 739 - 749

Опубликована: Фев. 14, 2017

There is mounting evidence for a connection between the gut and Parkinson's disease (PD). Dysbiosis of microbiota could explain several features PD.

Язык: Английский

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