Pharmacomicrobiomics: a novel route towards personalized medicine? DOI Creative Commons

Marwah Doestzada,

Arnau Vich Vila, Alexandra Zhernakova

и другие.

Protein & Cell, Год журнала: 2018, Номер 9(5), С. 432 - 445

Опубликована: Апрель 28, 2018

Inter-individual heterogeneity in drug response is a serious problem that affects the patient’s wellbeing and poses enormous clinical financial burdens on societal level. Pharmacogenomics has been at forefront of research into impact individual genetic background variability or toxicity, recently gut microbiome, which also called second genome, recognized as an important player this respect. Moreover, microbiome very attractive target for improving efficacy safety due to opportunities manipulate its composition. Pharmacomicrobiomics emerging field investigates interplay variation drugs disposition (absorption, distribution, metabolism excretion). In review, we provide historical overview examine current state-of-the-art knowledge complex interactions between host drugs. We argue combining pharmacogenomics pharmacomicrobiomics will foundation making major advances personalized medicine.

Язык: Английский

Where to Look into the Puzzle of Polyphenols and Health? The Postbiotics and Gut Microbiota Associated with Human Metabotypes DOI
Adrián Cortés‐Martín, María V. Selma, Francisco A. Tómas‐Barberán

и другие.

Molecular Nutrition & Food Research, Год журнала: 2020, Номер 64(9)

Опубликована: Март 20, 2020

Abstract The full consensus on the role of dietary polyphenols as human‐health‐promoting compounds remains elusive. two‐way interaction between and gut microbiota (GM) (i.e., modulation GM by their catabolism GM) is determinant in polyphenols’ effects. identification human metabotypes associated with a differential microbial metabolism has opened new research scenarios to explain inter‐individual variability upon consumption. unequivocally identified so far are those involved isoflavones (equol and(or) O ‐desmethylangolesin producers versus non‐producers) ellagic acid (urolithin metabotypes, including only urolithin‐A (UM‐A), urolithin‐A, isourolithin‐A, urolithin‐B (UM‐B), non‐producers (UM‐0)). In addition, metabolites (phenolic‐derived postbiotics) such equol, urolithins, valerolactones, enterolactone, enterodiol, 8‐prenylnaringenin, among others, can exert health knowledge updated position taken here i) polyphenols, ii) evidence phenolic‐derived postbiotics health, iii) biomarkers clustering individuals depending (metabotyping) effects, iv) catecholamines illustrate intersection personalized nutrition precision medicine.

Язык: Английский

Процитировано

227

Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol Level DOI Creative Commons
Douglas J. Kenny, Damian R. Plichta, Dmitry Shungin

и другие.

Cell Host & Microbe, Год журнала: 2020, Номер 28(2), С. 245 - 257.e6

Опубликована: Июнь 15, 2020

Язык: Английский

Процитировано

225

Gut microbiome lipid metabolism and its impact on host physiology DOI Creative Commons
Eric Brown, Jon Clardy, Ramnik J. Xavier

и другие.

Cell Host & Microbe, Год журнала: 2023, Номер 31(2), С. 173 - 186

Опубликована: Фев. 1, 2023

Язык: Английский

Процитировано

191

Microbial transmission in animal social networks and the social microbiome DOI
Amar Sarkar, Siobhán Harty, Katerina V.‐A. Johnson

и другие.

Nature Ecology & Evolution, Год журнала: 2020, Номер 4(8), С. 1020 - 1035

Опубликована: Июнь 22, 2020

Язык: Английский

Процитировано

177

Pharmacomicrobiomics: a novel route towards personalized medicine? DOI Creative Commons

Marwah Doestzada,

Arnau Vich Vila, Alexandra Zhernakova

и другие.

Protein & Cell, Год журнала: 2018, Номер 9(5), С. 432 - 445

Опубликована: Апрель 28, 2018

Inter-individual heterogeneity in drug response is a serious problem that affects the patient’s wellbeing and poses enormous clinical financial burdens on societal level. Pharmacogenomics has been at forefront of research into impact individual genetic background variability or toxicity, recently gut microbiome, which also called second genome, recognized as an important player this respect. Moreover, microbiome very attractive target for improving efficacy safety due to opportunities manipulate its composition. Pharmacomicrobiomics emerging field investigates interplay variation drugs disposition (absorption, distribution, metabolism excretion). In review, we provide historical overview examine current state-of-the-art knowledge complex interactions between host drugs. We argue combining pharmacogenomics pharmacomicrobiomics will foundation making major advances personalized medicine.

Язык: Английский

Процитировано

168