Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 17, 2025

The study of the multifaceted interactions between neuroscience and cancer is an emerging field with significant implications for understanding tumor biology innovation in therapeutic approaches. Increasing evidence suggests that neurological functions are connected tumorigenesis. In particular, peripheral central nervous systems, synapse, neurotransmitters, neurotrophins affect progression metastasis through various regulatory approaches immune microenvironment. this review, we summarized tumorigenesis metastasis, which controlled by systems. We also explored roles neurotransmitters progression. Moreover, examined interplay system have identified drugs target treatment. review present work supporting agent targeting could potential to improve therapy.

Язык: Английский

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Development and Therapeutic Potential of Small-Molecule Modulators of Circadian Systems

The Annual Review of Pharmacology and Toxicology, Год журнала: 2017, Номер 58(1), С. 231 - 252

Опубликована: Окт. 2, 2017

Circadian timekeeping systems drive oscillatory gene expression to regulate essential cellular and physiological processes. When the are perturbed, pathological consequences ensue disease risks rise. A growing number of small-molecule modulators have been reported target circadian systems. Such small molecules, identified via high-throughput screening or derivatized from known scaffolds, shown promise as drug candidates improve biological timing outputs in models. In this review, we first briefly describe system, including core oscillator networks. Research progress on clock-modulating molecules is presented, focusing development strategies efficacies. We highlight therapeutic potential clock-related pathologies, jet lag shiftwork; various chronic diseases, particularly metabolic disease; aging. Emerging opportunities identify exploit clock novel agents discussed.

Язык: Английский

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BMAL1 knockout macaque monkeys display reduced sleep and psychiatric disorders

National Science Review, Год журнала: 2019, Номер 6(1), С. 87 - 100

Опубликована: Янв. 1, 2019

Circadian disruption is a risk factor for metabolic, psychiatric and age-related disorders, non-human primate models could help to develop therapeutic treatments. Here, we report the generation of BMAL1 knockout cynomolgus monkeys circadian-related disorders by CRISPR/Cas9 editing monkey embryos. These showed higher nocturnal locomotion reduced sleep, which was further exacerbated constant light regimen. Physiological circadian reflected markedly dampened arrhythmic blood hormonal levels. Furthermore, BMAL1-deficient exhibited anxiety depression, consistent with their stably elevated cortisol, defective sensory processing in auditory oddball tests found schizophrenia patients. Ablation up-regulated transcriptional programs toward inflammatory stress responses, transcription networks associated human sleep deprivation, major depressive aging. Thus, are potentially useful studying physiological consequences disturbance, developing therapies disorders.

Язык: Английский

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Circadian control of lung inflammation in influenza infection

Nature Communications, Год журнала: 2019, Номер 10(1)

Опубликована: Сен. 11, 2019

Influenza is a leading cause of respiratory mortality and morbidity. While inflammation essential for fighting infection, balance anti-viral defense host tolerance necessary recovery. Circadian rhythms have been shown to modulate inflammation. However, the importance diurnal variability in timing influenza infection not well understood. Here we demonstrate that endogenous affect survival infection. control mediated by enhanced as proven increased cellularity bronchoalveolar lavage (BAL), pulmonary transcriptomic profile histology attributable viral burden. Better associated with time dependent preponderance NK NKT cells lower proportion inflammatory monocytes lung. Further, using series genetic mouse mutants, elucidate cellular mechanisms underlying circadian gating

Язык: Английский

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Circadian rhythms: a regulator of gastrointestinal health and dysfunction

Expert Review of Gastroenterology & Hepatology, Год журнала: 2019, Номер 13(5), С. 411 - 424

Опубликована: Март 15, 2019

Introduction: Circadian rhythms regulate much of gastrointestinal physiology including cell proliferation, motility, digestion, absorption, and electrolyte balance. Disruption circadian can have adverse consequences the promotion and/or exacerbation a wide variety disorders diseases.Areas covered: In this review, we evaluate some many functions that are regulated by how dysregulation these may contribute to disease. This review also discusses common known be influenced as well speculation about mechanisms which rhythm disruption promotes dysfunction disease pathogenesis. We discuss knowledge advent chrono-nutrition, chrono-pharmacology, chrono-therapeutics might influence clinical practice.Expert opinion: As our biology increases, it possible incorporate strategies take advantage chronotherapy prevent treat

Язык: Английский

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