Functional Classification and Experimental Dissection of Long Noncoding RNAs

Cell, Год журнала: 2018, Номер 172(3), С. 393 - 407

Опубликована: Янв. 1, 2018

Язык: Английский

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The Biogenesis, Functions, and Challenges of Circular RNAs

Molecular Cell, Год журнала: 2018, Номер 71(3), С. 428 - 442

Опубликована: Июль 26, 2018

Язык: Английский

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Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects

Signal Transduction and Targeted Therapy, Год журнала: 2020, Номер 5(1)

Опубликована: Янв. 3, 2020

Abstract Based on engineered or bacterial nucleases, the development of genome editing technologies has opened up possibility directly targeting and modifying genomic sequences in almost all eukaryotic cells. Genome extended our ability to elucidate contribution genetics disease by promoting creation more accurate cellular animal models pathological processes begun show extraordinary potential a variety fields, ranging from basic research applied biotechnology biomedical research. Recent progress developing programmable such as zinc-finger nucleases (ZFNs), transcription activator-like effector (TALENs) clustered regularly interspaced short palindromic repeat (CRISPR)–Cas-associated greatly expedited gene concept clinical practice. Here, we review recent advances three major (ZFNs, TALENs, CRISPR/Cas9) discuss applications their derivative reagents tools various human diseases future therapies, focusing cells models. Finally, provide an overview trials applying platforms for treatment some challenges implementation this technology.

Язык: Английский

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Cellular functions of long noncoding RNAs

Nature Cell Biology, Год журнала: 2019, Номер 21(5), С. 542 - 551

Опубликована: Май 1, 2019

Язык: Английский

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The next generation of CRISPR–Cas technologies and applications

Nature Reviews Molecular Cell Biology, Год журнала: 2019, Номер 20(8), С. 490 - 507

Опубликована: Май 30, 2019

Язык: Английский

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The functions and unique features of long intergenic non-coding RNA

Nature Reviews Molecular Cell Biology, Год журнала: 2017, Номер 19(3), С. 143 - 157

Опубликована: Ноя. 15, 2017

Язык: Английский

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Long non-coding RNAs: definitions, functions, challenges and recommendations

Nature Reviews Molecular Cell Biology, Год журнала: 2023, Номер 24(6), С. 430 - 447

Опубликована: Янв. 3, 2023

Язык: Английский

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Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations

Nature Genetics, Год журнала: 2019, Номер 51(12), С. 1664 - 1669

Опубликована: Ноя. 29, 2019

Язык: Английский

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Opportunities and challenges for transcriptome-wide association studies

Nature Genetics, Год журнала: 2019, Номер 51(4), С. 592 - 599

Опубликована: Март 29, 2019

Язык: Английский

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How do lncRNAs regulate transcription?

Science Advances, Год журнала: 2017, Номер 3(9)

Опубликована: Сен. 1, 2017

It has recently become apparent that RNA, itself the product of transcription, is a major regulator transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function many cases as regulators. These through binding to histone-modifying complexes, DNA proteins (including transcription factors), and even RNA polymerase II. other cases, it act lncRNA rather than appears be regulatory. We review recent progress elucidating molecular mechanisms by lncRNAs modulate gene expression future opportunities this research field.

Язык: Английский

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