DNA replication–coupled histone modification maintains Polycomb gene silencing in plants

Science, Год журнала: 2017, Номер 357(6356), С. 1146 - 1149

Опубликована: Авг. 18, 2017

A multifactorial strategy establishes and maintains repressive chromatin marks in plants response to environmental signals.

Язык: Английский

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The Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands

Molecular Cell, Год журнала: 2018, Номер 72(1), С. 140 - 151.e3

Опубликована: Сен. 20, 2018

Язык: Английский

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Dangerous liaisons: interplay between SWI/SNF, NuRD, and Polycomb in chromatin regulation and cancer

Genes & Development, Год журнала: 2019, Номер 33(15-16), С. 936 - 959

Опубликована: Май 23, 2019

Changes in chromatin structure mediated by ATP-dependent nucleosome remodelers and histone modifying enzymes are integral to the process of gene regulation. Here, we review roles SWI/SNF (switch/sucrose nonfermenting) NuRD (nucleosome remodeling deacetylase) Polycomb system regulation cancer. First, discuss basic molecular mechanism remodeling, how this controls transcription. Next, provide an overview functional organization biochemical activities SWI/SNF, NuRD, complexes. We describe how, metazoans, balance these is central proper expression cellular identity during development. Whereas counteracts Polycomb, facilitates repression on chromatin. Finally, disruptions regulatory equilibrium contribute oncogenesis, new insights into biological functions Polycombs opening avenues for therapeutic interventions a broad range cancer types.

Язык: Английский

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Genomic imprinting in plants—revisiting existing models

Genes & Development, Год журнала: 2020, Номер 34(1-2), С. 24 - 36

Опубликована: Янв. 1, 2020

Genomic imprinting is an epigenetic phenomenon leading to parentally biased gene expression. Throughout the years, extensive efforts have been made characterize marks underlying in animals and plants. As a result, DNA methylation asymmetries between parental genomes emerged as primary factor controlling status of many genes. Nevertheless, data accumulated so far suggest that this process cannot solely explain all In review, we revisit current models explaining regulation plants, discuss novel regulatory mechanisms could function independently establishment imprinting.

Язык: Английский

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The molecular basis of heterochromatin assembly and epigenetic inheritance

Molecular Cell, Год журнала: 2023, Номер 83(11), С. 1767 - 1785

Опубликована: Май 18, 2023

Язык: Английский

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