The machineries, regulation and cellular functions of mitochondrial calcium

Nature Reviews Molecular Cell Biology, Год журнала: 2018, Номер 19(11), С. 713 - 730

Опубликована: Авг. 24, 2018

Язык: Английский

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Here, there, and everywhere: The importance of ER membrane contact sites

Science, Год журнала: 2018, Номер 361(6401)

Опубликована: Авг. 3, 2018

It's all about your contacts Membrane contact sites have recently come to the fore of our understanding interorganelle communication. Wu et al. review how these important structures help promote a variety key functions, including organelle division and lipid transfer. Focusing on between endoplasmic reticulum organelles or plasma membrane reveals generality importance in cellular homeostasis organismal health. Science , this issue p. eaan5835

Язык: Английский

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Coming together to define membrane contact sites

Nature Communications, Год журнала: 2019, Номер 10(1)

Опубликована: Март 20, 2019

Abstract Close proximities between organelles have been described for decades. However, only recently a specific field dealing with organelle communication at membrane contact sites has gained wide acceptance, attracting scientists from multiple areas of cell biology. The diversity approaches warrants unified vocabulary the field. Such definitions would facilitate laying foundations this field, streamlining and resolving semantic controversies. This opinion, written by panel experts in aims to provide burgeoning area guidelines experimental definition analysis sites. It also includes suggestions on how operationally tractably measure analyze them hope ultimately facilitating knowledge production dissemination within outside contact-site research.

Язык: Английский

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Visualizing Intracellular Organelle and Cytoskeletal Interactions at Nanoscale Resolution on Millisecond Timescales

Cell, Год журнала: 2018, Номер 175(5), С. 1430 - 1442.e17

Опубликована: Окт. 25, 2018

Язык: Английский

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The functional universe of membrane contact sites

Nature Reviews Molecular Cell Biology, Год журнала: 2019, Номер 21(1), С. 7 - 24

Опубликована: Ноя. 15, 2019

Язык: Английский

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Distinct fission signatures predict mitochondrial degradation or biogenesis

Nature, Год журнала: 2021, Номер 593(7859), С. 435 - 439

Опубликована: Май 5, 2021

Язык: Английский

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VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites

The Journal of Cell Biology, Год журнала: 2018, Номер 217(10), С. 3625 - 3639

Опубликована: Авг. 9, 2018

Mutations in the human VPS13 genes are responsible for neurodevelopmental and neurodegenerative disorders including chorea acanthocytosis (VPS13A) Parkinson’s disease (VPS13C). The mechanisms of these diseases unknown. Genetic studies yeast hinted that Vps13 may have a role lipid exchange between organelles. In this study, we show N-terminal portion is tubular, with hydrophobic cavity can solubilize transport glycerolipids membranes. We also VPS13A VPS13C bind to ER, tethering it mitochondria (VPS13A), late endosome/lysosomes (VPS13C), droplets (both VPS13C). These findings identify as transporter ER other organelles, implicating defects membrane homeostasis neurological resulting from their mutations. Sequence secondary structure similarity portions proteins such autophagy protein ATG2 suggest roles well.

Язык: Английский

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Endoplasmic Reticulum–Mitochondrial Contactology: Structure and Signaling Functions

Trends in Cell Biology, Год журнала: 2018, Номер 28(7), С. 523 - 540

Опубликована: Март 24, 2018

Язык: Английский

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Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes

Nature Reviews Molecular Cell Biology, Год журнала: 2018, Номер 20(2), С. 85 - 101

Опубликована: Окт. 18, 2018

Язык: Английский

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Mitochondria in health, disease, and aging

Physiological Reviews, Год журнала: 2023, Номер 103(4), С. 2349 - 2422

Опубликована: Апрель 6, 2023

Mitochondria are well known as organelles responsible for the maintenance of cellular bioenergetics through production ATP. Although oxidative phosphorylation may be their most important function, mitochondria also integral synthesis metabolic precursors, calcium regulation, reactive oxygen species, immune signaling, and apoptosis. Considering breadth responsibilities, fundamental metabolism homeostasis. Appreciating this significance, translational medicine has begun to investigate how mitochondrial dysfunction can represent a harbinger disease. In review, we provide detailed overview metabolism, bioenergetics, dynamics, autophagy, damage-associated molecular patterns, mitochondria-mediated cell death pathways, at any these levels is associated with disease pathogenesis. Mitochondria-dependent pathways thereby an attractive therapeutic target ameliorating human

Язык: Английский

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