Journal of the American Chemical Society,
Год журнала:
2018,
Номер
140(50), С. 17433 - 17438
Опубликована: Дек. 5, 2018
A
strategy
for
the
installation
of
small
alkyl
fragments
onto
pharmaceutically
relevant
aliphatic
structures
has
been
established
via
metallaphotoredox
catalysis.
Herein,
we
report
that
tris(trimethylsilyl)silanol
can
be
employed
as
an
effective
halogen
abstraction
reagent
that,
in
combination
with
photoredox
and
nickel
catalysis,
allows
a
generic
approach
to
Csp3–Csp3
cross-electrophile
coupling.
In
this
study,
demonstrate
variety
drug-like
groups
successfully
coupled
number
commercially
available
electrophiles,
including
methyl
tosylate
strained
cyclic
bromides.
Moreover,
union
two
secondary
carbon
centers,
long-standing
challenge
organic
molecule
construction,
accomplished
wide
array
structural
formats.
Last,
technology
selectively
merged
Csp2–Csp3
aryl–alkyl
couplings
build
systems
highly
modular
fashion.
Chemical Reviews,
Год журнала:
2021,
Номер
122(2), С. 1485 - 1542
Опубликована: Ноя. 18, 2021
The
merger
of
photoredox
catalysis
with
transition
metal
catalysis,
termed
metallaphotoredox
has
become
a
mainstay
in
synthetic
methodology
over
the
past
decade.
Metallaphotoredox
combined
unparalleled
capacity
for
bond
formation
broad
utility
photoinduced
electron-
and
energy-transfer
processes.
Photocatalytic
substrate
activation
allowed
engagement
simple
starting
materials
metal-mediated
bond-forming
Moreover,
electron
or
energy
transfer
directly
key
organometallic
intermediates
provided
novel
modes
entirely
complementary
to
traditional
catalytic
platforms.
This
Review
details
contextualizes
advancements
molecule
construction
brought
forth
by
metallaphotocatalysis.
Chemical Reviews,
Год журнала:
2019,
Номер
119(14), С. 8701 - 8780
Опубликована: Июнь 25, 2019
Organosulfur
compounds
have
long
played
a
vital
role
in
organic
chemistry
and
the
development
of
novel
chemical
structures
architectures.
Prominent
among
these
organosulfur
are
those
involving
sulfur(IV)
center,
which
been
subject
countless
investigations
over
more
than
hundred
years.
In
addition
to
list
textbook
sulfur-based
reactions,
there
has
sustained
interest
organosulfur(IV)
recent
Of
particular
within
is
ease
with
synthetic
chemist
can
effect
wide
range
transformations
through
either
bond
formation
or
cleavage
at
sulfur.
This
review
aims
cover
developments
past
decade
molecules
provide
insight
into
both
reactions
critically
rely
on
this
versatile
element
diverse
scaffolds
that
thereby
be
synthesized.
Visible-light
photoredox
catalysis
offers
a
distinct
activation
mode
complementary
to
thermal
transition
metal
catalyzed
reactions.
The
vast
majority
of
processes
capitalizes
on
precious
ruthenium(II)
or
iridium(III)
complexes
that
serve
as
single-electron
reductants
oxidants
in
their
photoexcited
states.
As
low-cost
alternative,
organic
dyes
are
also
frequently
used
but
general
suffer
from
lower
photostability.
Copper-based
photocatalysts
rapidly
emerging,
offering
not
only
economic
and
ecological
advantages
otherwise
inaccessible
inner-sphere
mechanisms,
which
have
been
successfully
applied
challenging
transformations.
Moreover,
the
combination
conventional
with
copper(I)
copper(II)
salts
has
emerged
an
efficient
dual
catalytic
system
for
cross-coupling
Chemical Reviews,
Год журнала:
2021,
Номер
122(2), С. 1543 - 1625
Опубликована: Окт. 8, 2021
In
recent
years,
visible
light-induced
transition
metal
catalysis
has
emerged
as
a
new
paradigm
in
organic
photocatalysis,
which
led
to
the
discovery
of
unprecedented
transformations
well
improvement
known
reactions.
this
subfield
complex
serves
double
duty
by
harvesting
photon
energy
and
then
enabling
bond
forming/breaking
events
mostly
via
single
catalytic
cycle,
thus
contrasting
established
dual
photocatalysis
an
exogenous
photosensitizer
is
employed.
addition,
approach
often
synergistically
combines
catalyst–substrate
interaction
with
photoinduced
process,
feature
that
uncommon
conventional
photoredox
chemistry.
This
Review
describes
early
development
advances
emerging
field.
Science,
Год журнала:
2020,
Номер
367(6481), С. 1021 - 1026
Опубликована: Фев. 27, 2020
Organic
halides
are
important
building
blocks
in
synthesis,
but
their
use
(photo)redox
chemistry
is
limited
by
low
reduction
potentials.
Halogen-atom
transfer
remains
the
most
reliable
approach
to
exploit
these
substrates
radical
processes
despite
its
requirement
for
hazardous
reagents
and
initiators
such
as
tributyltin
hydride.
In
this
study,
we
demonstrate
that
α-aminoalkyl
radicals,
easily
accessible
from
simple
amines,
promote
homolytic
activation
of
carbon-halogen
bonds
with
a
reactivity
profile
mirroring
classical
tin
radicals.
This
strategy
conveniently
engages
alkyl
aryl
wide
range
redox
transformations
construct
sp3-sp3,
sp3-sp2,
sp2-sp2
carbon-carbon
under
mild
conditions
high
chemoselectivity.
Chemical Reviews,
Год журнала:
2021,
Номер
122(2), С. 2292 - 2352
Опубликована: Дек. 9, 2021
The
halogen-atom
transfer
(XAT)
is
one
of
the
most
important
and
applied
processes
for
generation
carbon
radicals
in
synthetic
chemistry.
In
this
review,
we
summarize
highlight
aspects
associated
with
XAT
impact
it
has
had
on
photochemistry
photocatalysis.
organization
material
starts
analysis
mechanistic
then
follows
a
subdivision
based
nature
reagents
used
halogen
abstraction.
This
review
aims
to
provide
general
overview
fundamental
concepts
main
agents
involved
objective
offering
tool
understand
facilitate
development
new
radical
strategies.
Nature Communications,
Год журнала:
2020,
Номер
11(1)
Опубликована: Фев. 6, 2020
Can
organic
chemistry
mimic
nature
in
efficiency
and
sustainability?
Not
yet,
but
recent
developments
photoredox
catalysis
animated
the
synthetic
field,
providing
greener
opportunities
for
industry
academia.
Chemical Society Reviews,
Год журнала:
2021,
Номер
50(13), С. 7587 - 7680
Опубликована: Янв. 1, 2021
Organic
compounds
that
show
Thermally
Activated
Delayed
Fluorescence
(TADF)
have
become
wildly
popular
as
next
generation
emitters
in
organic
light-emitting
diodes
(OLEDs),
but
since
2016,
received
significant
and
increasing
attention
photocatalysts.
Chemical Society Reviews,
Год журнала:
2020,
Номер
50(2), С. 766 - 897
Опубликована: Дек. 22, 2020
Recent
developments
and
future
prospects
of
visible-light
photocatalysis
in
the
late-stage
functionalization
pharmaceuticals
natural
bioactive
compounds.
