Nature Genetics, Год журнала: 2020, Номер 52(9), С. 870 - 877
Опубликована: Авг. 10, 2020
Язык: Английский
Nature Genetics, Год журнала: 2020, Номер 52(9), С. 870 - 877
Опубликована: Авг. 10, 2020
Язык: Английский
Molecular Cell, Год журнала: 2019, Номер 74(4), С. 640 - 650
Опубликована: Май 1, 2019
Язык: Английский
Процитировано
1486Molecular Cancer, Год журнала: 2019, Номер 18(1)
Опубликована: Дек. 1, 2019
N6-methyladenosine (m6A) is methylation that occurs in the N6-position of adenosine, which most prevalent internal modification on eukaryotic mRNA. Accumulating evidence suggests m6A modulates gene expression, thereby regulating cellular processes ranging from cell self-renewal, differentiation, invasion and apoptosis. M6A installed by methyltransferases, removed demethylases recognized reader proteins, regulate RNA metabolism including translation, splicing, export, degradation microRNA processing. Alteration levels participates cancer pathogenesis development via expression tumor-related genes like BRD4, MYC, SOCS2 EGFR. In this review, we elaborate recent advances research enzymes. We also highlight underlying mechanism progression. Finally, review corresponding potential targets therapy.
Язык: Английский
Процитировано
1102Cancer Cell, Год журнала: 2020, Номер 37(3), С. 270 - 288
Опубликована: Март 1, 2020
Язык: Английский
Процитировано
950Cancer Cell, Год журнала: 2020, Номер 38(1), С. 79 - 96.e11
Опубликована: Июнь 11, 2020
Язык: Английский
Процитировано
587Science, Год журнала: 2020, Номер 367(6477), С. 580 - 586
Опубликована: Янв. 17, 2020
A new layer of transcriptional control N 6 -methyladenosine (m A) is the most abundant messenger RNA modification in almost all eukaryotes. Liu et al. now show that m also cotranscriptionally added onto various chromosome-associated regulatory RNAs (carRNAs) mammalian cells. Disruption these increases their abundance and promotes gene transcription by increasing chromatin accessibility. Thus, serves as a switch to regulate carRNA levels tuning nearby state downstream transcription. Science , this issue p. 580
Язык: Английский
Процитировано
542Molecular Cell, Год журнала: 2019, Номер 74(6), С. 1304 - 1316.e8
Опубликована: Апрель 25, 2019
Язык: Английский
Процитировано
411Cell, Год журнала: 2021, Номер 184(12), С. 3109 - 3124.e22
Опубликована: Май 17, 2021
Язык: Английский
Процитировано
411Molecular Cancer, Год журнала: 2021, Номер 20(1)
Опубликована: Янв. 18, 2021
Abstract RNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programmes. Significant advances been made in understanding the functional role regulating coding and non-coding processing function, which turn thoroughly shape distinct They affect diverse biological processes, correct deposition many these is required for normal development. Alterations their are implicated several diseases, including cancer. In this Review, we focus on occurrence N 6 -methyladenosine (m A), 5-methylcytosine 5 C) pseudouridine (Ψ) RNAs describe physiopathological We will highlight latest insights into mechanisms how influence tumour development, maintenance, progression. Finally, summarize development small molecule inhibitors that target specific writers or erasers to rewind epitranscriptome a cancer cell therapeutic potential.
Язык: Английский
Процитировано
362Nature Chemical Biology, Год журнала: 2018, Номер 15(1), С. 88 - 94
Опубликована: Дек. 4, 2018
Язык: Английский
Процитировано
344Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)
Опубликована: Ноя. 7, 2022
Abstract Aging is accompanied by the decline of organismal functions and a series prominent hallmarks, including genetic epigenetic alterations. These aging-associated changes include DNA methylation, histone modification, chromatin remodeling, non-coding RNA (ncRNA) regulation, all which participate in regulation aging process, hence contribute to aging-related diseases. Therefore, understanding mechanisms will provide new avenues develop strategies delay aging. Indeed, interventions based on manipulating have led alleviation or extension lifespan animal models. Small molecule-based therapies reprogramming that enable rejuvenation been developed for ameliorating reversing conditions. In addition, adopting health-promoting activities, such as caloric restriction, exercise, calibrating circadian rhythm, has demonstrated Furthermore, various clinical trials intervention are ongoing, providing more evidence safety efficacy these therapies. Here, we review recent work outline advances age-associated A better critical roles epigenetics process lead prevention human therapy
Язык: Английский
Процитировано
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