Hallmarks of aging: An expanding universe

Cell, Год журнала: 2023, Номер 186(2), С. 243 - 278

Опубликована: Янв. 1, 2023

Язык: Английский

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A compendium of mutational cancer driver genes

Nature reviews. Cancer, Год журнала: 2020, Номер 20(10), С. 555 - 572

Опубликована: Авг. 10, 2020

Язык: Английский

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The evolutionary history of 2,658 cancers

Nature, Год журнала: 2020, Номер 578(7793), С. 122 - 128

Опубликована: Фев. 5, 2020

Cancer develops through a process of somatic evolution

Язык: Английский

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Clonal hematopoiesis in human aging and disease

Science, Год журнала: 2019, Номер 366(6465)

Опубликована: Окт. 31, 2019

As people age, their tissues accumulate an increasing number of somatic mutations. Although most these mutations are little or no functional consequence, a mutation may arise that confers fitness advantage on cell. When this process happens in the hematopoietic system, substantial proportion circulating blood cells derive from single mutated stem This outgrowth, called "clonal hematopoiesis," is highly prevalent elderly population. Here we discuss recent advances our knowledge clonal hematopoiesis, its relationship to malignancies, link nonmalignant diseases aging, and potential impact immune function. Clonal hematopoiesis provides glimpse into selection likely occurs all tissues.

Язык: Английский

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DNA methylation aging clocks: challenges and recommendations

Genome biology, Год журнала: 2019, Номер 20(1)

Опубликована: Ноя. 25, 2019

Abstract Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These are acknowledged as highly accurate molecular correlate chronological age in humans and other vertebrates. Also, extensive research is aimed at their potential to quantify biological aging rates test longevity or rejuvenating interventions. Here, we discuss key challenges understand clock mechanisms biomarker utility. This requires dissecting the drivers regulators age-related changes single-cell, tissue- disease-specific models, well exploring epigenomic marks, longitudinal diverse population studies, non-human models. We also highlight important ethical issues forensic determination predicting trajectory an individual.

Язык: Английский

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The landscape of somatic mutation in normal colorectal epithelial cells

Nature, Год журнала: 2019, Номер 574(7779), С. 532 - 537

Опубликована: Окт. 23, 2019

Язык: Английский

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p53: 800 million years of evolution and 40 years of discovery

Nature reviews. Cancer, Год журнала: 2020, Номер 20(8), С. 471 - 480

Опубликована: Май 13, 2020

Язык: Английский

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Cancer therapy shapes the fitness landscape of clonal hematopoiesis

Nature Genetics, Год журнала: 2020, Номер 52(11), С. 1219 - 1226

Опубликована: Окт. 26, 2020

Язык: Английский

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RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues

Science, Год журнала: 2019, Номер 364(6444)

Опубликована: Июнь 6, 2019

How somatic mutations accumulate in normal cells is poorly understood. A comprehensive analysis of RNA sequencing data from ~6700 samples across 29 tissues revealed multiple variants, demonstrating that macroscopic clones can be found many tissues. We sun-exposed skin, esophagus, and lung have a higher mutation burden than other tested tissues, which suggests environmental factors promote mosaicism. Mutation was associated with both age tissue-specific cell proliferation rate, highlighting over time number divisions. Finally, were to harbor known cancer genes hotspots. This study provides broad view clonal expansion human thus serving as foundation for associating factors, aging, risk disease.

Язык: Английский

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Tobacco smoking and somatic mutations in human bronchial epithelium

Nature, Год журнала: 2020, Номер 578(7794), С. 266 - 272

Опубликована: Янв. 29, 2020

Язык: Английский

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