Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation

Molecular Cell, Год журнала: 2021, Номер 81(16), С. 3368 - 3385.e9

Опубликована: Авг. 1, 2021

Язык: Английский

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Regulation of Gene Expression by N-methyladenosine in Cancer

Trends in Cell Biology, Год журнала: 2019, Номер 29(6), С. 487 - 499

Опубликована: Март 30, 2019

Язык: Английский

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Atlas of quantitative single-base-resolution N6-methyl-adenine methylomes

Nature Communications, Год журнала: 2019, Номер 10(1)

Опубликована: Дек. 10, 2019

Abstract Various methyltransferases and demethylases catalyse methylation demethylation of N 6 -methyladenosine (m6A) ,2′-O-dimethyladenosine (m6Am) but precise methylomes uniquely mediated by each methyltransferase/demethylase are still lacking. Here, we develop m6A-Crosslinking-Exonuclease-sequencing (m6ACE-seq) to map transcriptome-wide m6A m6Am at quantitative single-base-resolution. This allows for the generation a comprehensive atlas distinct every individual known methyltransferase or demethylase. Our reveals METTL16 indirectly impact manifold targets beyond its consensus target motif highlights importance precision in mapping PCIF1-dependent m6Am. Rather than reverse RNA methylation, find that both ALKBH5 FTO instead maintain their regulated sites an unmethylated steady-state. In FTO’s absence, anomalous disrupts snRNA interaction with nuclear export machinery, potentially causing aberrant pre-mRNA splicing events.

Язык: Английский

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FTO mediates LINE1 m ⁶ A demethylation and chromatin regulation in mESCs and mouse development

Science, Год журнала: 2022, Номер 376(6596), С. 968 - 973

Опубликована: Май 5, 2022

-methyladenosine (m

Язык: Английский

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RNA demethylation increases the yield and biomass of rice and potato plants in field trials

Nature Biotechnology, Год журнала: 2021, Номер 39(12), С. 1581 - 1588

Опубликована: Июль 22, 2021

Язык: Английский

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