Cell Death and Disease,
Год журнала:
2024,
Номер
15(7)
Опубликована: Июль 4, 2024
Abstract
Autoimmune
diseases
commonly
affect
various
systems,
but
their
etiology
and
pathogenesis
remain
unclear.
Currently,
increasing
research
has
highlighted
the
role
of
ferroptosis
in
immune
regulation,
with
cells
being
a
crucial
component
body’s
system.
This
review
provides
an
overview
discusses
relationship
between
ferroptosis,
programmed
cell
death
cells,
autoimmune
diseases.
Additionally,
it
summarizes
key
targets
such
as
GPX4
TFR,
responses.
Furthermore,
release
multiple
molecules,
including
damage-associated
molecular
patterns
(DAMPs),
following
by
is
examined,
these
molecules
further
influence
differentiation
function
thereby
affecting
occurrence
progression
Moreover,
secrete
factors
or
metabolites,
which
also
impact
target
organs
tissues
involved
Iron
chelators,
chloroquine
its
derivatives,
antioxidants,
calreticulin
have
been
demonstrated
to
be
effective
animal
studies
for
certain
diseases,
exerting
anti-inflammatory
immunomodulatory
effects.
Finally,
brief
summary
future
perspectives
on
are
provided,
aiming
guide
disease
treatment
strategies.
Philosophical Transactions of the Royal Society B Biological Sciences,
Год журнала:
2024,
Номер
379(1900)
Опубликована: Март 4, 2024
Epigenetic
changes
are
known
to
accrue
in
normal
cells
as
a
result
of
ageing
and
cumulative
exposure
cancer
risk
factors.
Increasing
evidence
points
towards
age-related
epigenetic
being
acquired
quasi-stochastic
manner,
that
they
may
play
causal
role
development.
Here,
I
describe
the
nature
DNA
methylation
(DNAm)
well
at
neoplastic
transformation,
discussing
implications
this
stochasticity
for
developing
prediction
strategies,
particular,
how
it
require
conceptual
paradigm
shift
we
select
markers.
also
mounting
significant
proportion
DNAm
development
related
cell
proliferation,
reflecting
tissue-turnover
opportunity
offers
predicting
via
mitotic-like
clocks.
Finally,
age-associated
be
causally
implicated
an
irreversible
suppression
tissue-specific
transcription
factors
increases
transcriptomic
entropy,
promoting
more
plastic
yet
aberrant
stem-cell
state.
This
article
is
part
discussion
meeting
issue
‘Causes
consequences
stochastic
processes
disease’.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(10), С. 5083 - 5083
Опубликована: Май 7, 2024
Periodontitis
is
linked
to
the
onset
and
progression
of
oral
squamous
cell
carcinoma
(OSCC),
an
epidemiologically
frequent
clinically
aggressive
malignancy.
In
this
context,
Fusobacterium
(F.)
nucleatum
Porphyromonas
(P.)
gingivalis,
two
bacteria
that
cause
periodontitis,
are
found
in
OSCC
tissues
as
well
premalignant
lesions,
where
they
exert
pro-tumorigenic
activities.
Since
present
also
endodontic
diseases,
playing
a
role
their
pathogenesis,
here
we
analyze
literature
searching
for
information
on
impact
infection
by
P.
gingivalis
or
F.
could
have
cellular
molecular
events
involved
carcinogenesis.
Results
from
reviewed
papers
indicate
and/or
triggers
production
inflammatory
cytokines
growth
factors
dental
pulp
cells
periodontal
cells,
affecting
survival,
proliferation,
invasion,
differentiation
cells.
addition,
induce
halt
stimulate
proliferation
invasion
stem
populating
periodontium.
Although
most
confutes
possibility
bacteria-induced
diseases
carcinogenesis,
analyzed
discussed
herein
recommend
further
investigations
topic.
Abstract
Breast
cancer
(BC)
is
the
most
frequent
malignant
diagnosis
and
a
primary
factor
for
deaths
in
women.
The
clinical
subtypes
of
BC
include
estrogen
receptor
(ER)
positive,
progesterone
(PR)
human
epidermal
growth
2
(HER2)
triple-negative
(TNBC).
Based
on
stages
BC,
various
treatment
methods
are
available
with
variations
rates
progression-free
disease
overall
survival
patients.
However,
still
faces
challenges,
particularly
terms
drug
resistance
recurrence.
study
epigenetics
has
provided
new
ideas
treating
BC.
Targeting
aberrant
epigenetic
factors
inhibitors
represents
promising
anticancer
strategy.
KDM5
family
includes
four
members,
KDM5A,
KDM5B,
KDM5C,
KDMD,
all
which
Jumonji
C
domain-containing
histone
H3K4me2/3
demethylases.
proteins
have
been
extensively
studied
where
they
involved
suppressing
or
promoting
depending
their
specific
upstream
downstream
pathways.
Several
shown
potent
inhibitory
activity
vitro
vivo,
but
challenges
exist
developing
inhibitors.
In
this
review,
we
introduce
current
therapeutic
options,
summarize
context-specific
functions
pathobiology
discuss
outlook
pitfalls
disease.
Cell Death and Disease,
Год журнала:
2024,
Номер
15(7)
Опубликована: Июль 4, 2024
Abstract
Autoimmune
diseases
commonly
affect
various
systems,
but
their
etiology
and
pathogenesis
remain
unclear.
Currently,
increasing
research
has
highlighted
the
role
of
ferroptosis
in
immune
regulation,
with
cells
being
a
crucial
component
body’s
system.
This
review
provides
an
overview
discusses
relationship
between
ferroptosis,
programmed
cell
death
cells,
autoimmune
diseases.
Additionally,
it
summarizes
key
targets
such
as
GPX4
TFR,
responses.
Furthermore,
release
multiple
molecules,
including
damage-associated
molecular
patterns
(DAMPs),
following
by
is
examined,
these
molecules
further
influence
differentiation
function
thereby
affecting
occurrence
progression
Moreover,
secrete
factors
or
metabolites,
which
also
impact
target
organs
tissues
involved
Iron
chelators,
chloroquine
its
derivatives,
antioxidants,
calreticulin
have
been
demonstrated
to
be
effective
animal
studies
for
certain
diseases,
exerting
anti-inflammatory
immunomodulatory
effects.
Finally,
brief
summary
future
perspectives
on
are
provided,
aiming
guide
disease
treatment
strategies.
