Chemical proteomics approaches for protein post-translational modification studies DOI Creative Commons
Nan Zhang, Jinghua Wu, Qingfei Zheng

и другие.

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Год журнала: 2024, Номер 1872(4), С. 141017 - 141017

Опубликована: Апрель 18, 2024

The diversity and dynamics of proteins play essential roles in maintaining the basic constructions functions cells. abundance functional is regulated by transcription translation processes, while alternative splicing enables same gene to generate distinct protein isoforms different lengths. Beyond transcriptional translational regulations, post-translational modifications (PTMs) are able further expand scope proteins. PTMs have been shown make significant changes surface charges, structures, activation states, interactome Due complexity, highly dynamic nature, low presence percentage, study remains challenging. Here we summarize discuss major chemical biology tools proteomics approaches enrich investigate PTM interest.

Язык: Английский

Histone post-translational modifications — cause and consequence of genome function DOI
Gonzalo Millán-Zambrano,

Adam Burton,

Andrew J. Bannister

и другие.

Nature Reviews Genetics, Год журнала: 2022, Номер 23(9), С. 563 - 580

Опубликована: Март 25, 2022

Язык: Английский

Процитировано

646

The evolving metabolic landscape of chromatin biology and epigenetics DOI
Ziwei Dai, Vijyendra Ramesh, Jason W. Locasale

и другие.

Nature Reviews Genetics, Год журнала: 2020, Номер 21(12), С. 737 - 753

Опубликована: Сен. 9, 2020

Язык: Английский

Процитировано

371

Mitochondrial signal transduction DOI Creative Commons
Martin Picard, Orian S. Shirihai

Cell Metabolism, Год журнала: 2022, Номер 34(11), С. 1620 - 1653

Опубликована: Ноя. 1, 2022

The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic, maternally inherited, energy-transforming, biosynthetic, and signaling organelles that actively transduce biological information. We argue the processor cell, together with nucleus other they constitute mitochondrial information processing system (MIPS). In a three-step process, (1) sense respond to both endogenous environmental inputs through morphological functional remodeling; (2) integrate network-based physical interactions diffusion mechanisms; (3) produce output signals tune functions systemically regulate physiology. This input-to-output transformation allows metabolic, biochemical, neuroendocrine, local or systemic enhance organismal adaptation. An explicit focus on signal transduction emphasizes role communication in biology. framework also opens new avenues understand how mediate inter-organ processes underlying human health.

Язык: Английский

Процитировано

337

Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study DOI Creative Commons
Yanlin Wu, Zhengjun Lin, Changchun Li

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Март 2, 2023

Abstract Epigenetics regulates gene expression and has been confirmed to play a critical role in variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease (NAFLD), osteoporosis, gout, hyperthyroidism, hypothyroidism others. The term ‘epigenetics’ was firstly proposed 1942 with the development technologies, exploration epigenetics made great progresses. There are four main epigenetic mechanisms, including DNA methylation, histone modification, chromatin remodelling, noncoding RNA (ncRNA), which exert different effects on diseases. Genetic non-genetic factors, ageing, diet, exercise, interact jointly affect formation phenotype. Understanding could be applied diagnosing treating diseases clinic, biomarkers, drugs, editing. In this review, we introduce brief history well milestone events since proposal ‘epigenetics’. Moreover, summarise research methods general mechanisms modulation. Furthermore, interaction between genetic or factors. Finally, clinical trials applications

Язык: Английский

Процитировано

200

The role of histone modifications: from neurodevelopment to neurodiseases DOI Creative Commons
Jisu Park, Kyubin Lee, Kyunghwan Kim

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Июль 6, 2022

Abstract Epigenetic regulatory mechanisms, including DNA methylation, histone modification, chromatin remodeling, and microRNA expression, play critical roles in cell differentiation organ development through spatial temporal gene regulation. Neurogenesis is a sophisticated complex process by which neural stem cells differentiate into specialized brain types at specific times regions of the brain. A growing body evidence suggests that epigenetic such as modifications, allow fine-tuning coordination spatiotemporal expressions during neurogenesis. Aberrant modifications contribute to neurodegenerative neuropsychiatric diseases. Herein, recent progress understanding regulating embryonic adult neurogenesis comprehensively reviewed. The implicated diseases are also covered, future directions this area provided.

Язык: Английский

Процитировано

163

Candidate pathways for retina to scleral signaling in refractive eye growth DOI Creative Commons
Dillon M. Brown,

Reece Mazade,

Danielle Clarkson-Townsend

и другие.

Experimental Eye Research, Год журнала: 2022, Номер 219, С. 109071 - 109071

Опубликована: Апрель 18, 2022

The global prevalence of myopia, or nearsightedness, has increased at an alarming rate over the last few decades. An eye is myopic if incoming light focuses prior to reaching retinal photoreceptors, which indicates a mismatch in its shape and optical power. This commonly results from excessive axial elongation. Important drivers myopia epidemic include environmental factors, genetic their interactions, e.g., factors influencing effects factors. One factor often hypothesized be driver light, changed drastically rapidly on scale. In support this, it well established that size regulated by homeostatic process incorporates visual cues (emmetropization). allows detect minimize refractive errors quite accurately locally time modulating elongation via remodeling outermost coat, sclera. Critically, emmetropization not dependent post-retinal processing. Thus, appear influence through retina-to-sclera, retinoscleral, signaling cascade, capable transmitting information innermost layer layer. Despite significant research interest, specifics retinoscleral pathways remain elusive. While pharmacological treatments have proven effective slowing (most notably topical atropine), mechanisms behind these are still fully understood. Additionally, several neuromodulators, neurotransmitters, other small molecules been found length and/or error influenced myopigenic cues, yet little progress made explaining how signal originates retina crosses highly vascular choroid affect Here, we compile synthesize evidence surrounding three major candidate receiving attention - dopamine, retinoic acid, adenosine. All candidates both correlational causal backing involvement implicated multiple independent groups across diverse species. Two presented for retina-originating 1) all-trans acid 2) choroidal blood flow scleral oxygenation. Evidence crosstalk between discussed context two mechanisms.

Язык: Английский

Процитировано

73

Cysteine carboxyethylation generates neoantigens to induce HLA-restricted autoimmunity DOI
Yue Zhai, Liang Chen, Qian Zhao

и другие.

Science, Год журнала: 2023, Номер 379(6637)

Опубликована: Март 16, 2023

Autoimmune diseases such as ankylosing spondylitis (AS) can be driven by emerging neoantigens that disrupt immune tolerance. Here, we developed a workflow to profile posttranslational modifications involved in neoantigen formation. Using mass spectrometry, identified panel of cysteine residues differentially modified carboxyethylation required 3-hydroxypropionic acid generate patients with AS. The lysosomal degradation integrin αIIb [ITGA2B (CD41)] carboxyethylated at Cys96 (ITGA2B-ceC96) generated peptides were presented HLA-DRB1*04 stimulate CD4+ T cell responses and induce autoantibody production. Immunization HLA-DR4 transgenic mice the ITGA2B-ceC96 peptide promoted colitis vertebral bone erosion. Thus, metabolite-induced give rise pathogenic lead autoreactive production autoimmune diseases.

Язык: Английский

Процитировано

50

Disease-associated astrocyte epigenetic memory promotes CNS pathology DOI
Hong‐Gyun Lee, Joseph M. Rone, Zhaorong Li

и другие.

Nature, Год журнала: 2024, Номер 627(8005), С. 865 - 872

Опубликована: Март 20, 2024

Язык: Английский

Процитировано

43

Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response DOI

Xiadi He,

Qiwei Wang, Xin Cheng

и другие.

Cell, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

6

Bidirectional histone monoaminylation dynamics regulate neural rhythmicity DOI Creative Commons
Qingfei Zheng, Benjamin H. Weekley,

David A. Vinson

и другие.

Nature, Год журнала: 2025, Номер unknown

Опубликована: Янв. 8, 2025

Abstract Histone H3 monoaminylations at Gln5 represent an important family of epigenetic marks in brain that have critical roles permissive gene expression 1–3 . We previously demonstrated serotonylation 4–10 and dopaminylation 9,11–13 histone (H3Q5ser H3Q5dop, respectively) are catalysed by transglutaminase 2 (TG2), alter both local global chromatin states. Here we found TG2 additionally functions as eraser exchanger monoaminylations, including H3Q5 histaminylation (H3Q5his), which displays diurnally rhythmic contributes to circadian behaviour. H3Q5his, contrast H3Q5ser, inhibits the binding WDR5, a core member Lys4 (H3K4) methyltransferase complexes, thereby antagonizing activities on H3K4. Taken together, these data elucidate mechanism through single regulatory enzyme has ability sense chemical microenvironments affect states cells, dynamics regulation neural rhythmicity.

Язык: Английский

Процитировано

4