Journal of Proteome Research,
Год журнала:
2020,
Номер
19(11), С. 4576 - 4586
Опубликована: Июнь 17, 2020
SARS-CoV-2
has
caused
the
largest
pandemic
of
twenty-first
century
(COVID-19),
threatening
life
and
economy
all
countries
in
world.
The
identification
novel
therapies
vaccines
that
can
mitigate
or
control
this
global
health
threat
is
among
most
important
challenges
facing
biomedical
sciences.
To
construct
a
long-term
strategy
to
fight
both
other
possible
future
threats
from
coronaviruses,
it
critical
understand
molecular
mechanisms
underlying
virus
action.
viral
entry
associated
infectivity
stems
formation
spike
protein
complex
with
angiotensin-converting
enzyme
2
(ACE2).
detection
putative
allosteric
sites
on
molecule
be
used
elucidate
pathways
targeted
drugs
weaken
spike-ACE2
interaction
and,
thus,
reduce
infectivity.
In
study,
we
present
results
application
different
computational
methods
aimed
at
detecting
protein.
adopted
tools
consisted
contact
networks
(PCNs),
SEPAS
(Affinity
by
Flexibility),
perturbation
response
scanning
(PRS)
based
elastic
network
modes.
All
these
were
applied
ACE2
SARS-CoV2
SARS-CoV
proteins.
analyses
converged
toward
specific
region
(allosteric
modulation
[AMR]),
complexes
predicted
act
as
an
site
modulating
binding
ACE2.
Preliminary
hepcidin
(a
strong
structural
sequence
AMR)
indicated
inhibitory
effect
affinity
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(20), С. 11069 - 11069
Опубликована: Окт. 14, 2021
The
ongoing
COVID-19
pandemic,
caused
by
the
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
became
a
globally
leading
public
health
concern
over
past
two
years.
Despite
development
and
administration
of
multiple
vaccines,
mutation
newer
strains
challenges
to
universal
immunity
has
shifted
focus
lack
efficacious
drugs
for
therapeutic
intervention
disease.
As
with
SARS-CoV,
MERS-CoV,
other
non-respiratory
viruses,
flavonoids
present
themselves
as
promising
given
their
success
in
silico,
vitro,
vivo,
more
recently,
clinical
studies.
This
review
focuses
on
data
from
vitro
studies
analyzing
effects
various
key
SARS-CoV-2
targets
presents
an
analysis
structure-activity
relationships
same.
From
27
primary
papers,
69
were
investigated
activities
against
targets,
ranging
3C-like
protease
(3CLpro)
less
explored
nucleocapsid
(N)
protein;
most
quercetin
myricetin
derivatives,
baicalein,
baicalin,
EGCG,
tannic
acid.
We
further
silico
featuring
list
involving
potential
flavonoid-rich
extracts
combination
synthetic
or
polyphenols
suggest
prospects
future
SARS-CoV-2.
Frontiers in Oncology,
Год журнала:
2021,
Номер
11
Опубликована: Сен. 6, 2021
Neoadjuvant
immunotherapy
has
the
potential
to
enhance
clinical
outcomes
by
increasing
anti-tumor
immune
responses
in
presence
of
abundant
tumor-derived
antigen
an
microenvironment
that
not
been
exposed
previous
therapy.
The
current
mainstay
advanced
head
and
neck
squamous
cell
carcinoma
(HNSCC)
treatment
remains
surgery
radiotherapy
with/without
conventional
chemotherapy.
Despite
this
multi-modality
treatment,
human
papillomavirus
(HPV)-negative
HNSCC
shows
poor
prognosis.
Treatment
intensification
with
neoadjuvant
(induction)
chemotherapies
platinum
drugs
are
insufficient
significantly
prolong
overall
survival.
Although
only
15-20%
patients
benefit,
immunotherapies
have
approved
widely
used
for
recurrent
metastatic
HNSCC.
These
successes
led
checkpoint
blockade
therapies
being
testing
earlier
settings.
Recent
trials
show
promising
results
methodology
change
algorithm
This
overview
examines
history
approaches
HNSCC,
especially
focuses
on
recent
topics
Journal of Proteome Research,
Год журнала:
2020,
Номер
19(11), С. 4576 - 4586
Опубликована: Июнь 17, 2020
SARS-CoV-2
has
caused
the
largest
pandemic
of
twenty-first
century
(COVID-19),
threatening
life
and
economy
all
countries
in
world.
The
identification
novel
therapies
vaccines
that
can
mitigate
or
control
this
global
health
threat
is
among
most
important
challenges
facing
biomedical
sciences.
To
construct
a
long-term
strategy
to
fight
both
other
possible
future
threats
from
coronaviruses,
it
critical
understand
molecular
mechanisms
underlying
virus
action.
viral
entry
associated
infectivity
stems
formation
spike
protein
complex
with
angiotensin-converting
enzyme
2
(ACE2).
detection
putative
allosteric
sites
on
molecule
be
used
elucidate
pathways
targeted
drugs
weaken
spike-ACE2
interaction
and,
thus,
reduce
infectivity.
In
study,
we
present
results
application
different
computational
methods
aimed
at
detecting
protein.
adopted
tools
consisted
contact
networks
(PCNs),
SEPAS
(Affinity
by
Flexibility),
perturbation
response
scanning
(PRS)
based
elastic
network
modes.
All
these
were
applied
ACE2
SARS-CoV2
SARS-CoV
proteins.
analyses
converged
toward
specific
region
(allosteric
modulation
[AMR]),
complexes
predicted
act
as
an
site
modulating
binding
ACE2.
Preliminary
hepcidin
(a
strong
structural
sequence
AMR)
indicated
inhibitory
effect
affinity
