Cholecystokinin neurons in the spinal trigeminal nucleus interpolaris regulate mechanically evoked predatory hunting in male mice DOI Creative Commons
Dandan Geng, Yaning Li, Bo Yang

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Март 14, 2025

Predatory hunting plays a critical role in animal survival. Motion-related vibrissal somatosensory signaling is essential for prey detection and mice. However, little known about the neural circuits that convert cues to trigger predatory hunting. Here, we report mechanical force onto area of male mice key stimulus Mechanically evoked was abrogated by chemogenetic inactivation cholecystokinin-positive (Cck+) neurons spinal trigeminal nucleus interpolaris (Sp5I). The Cck+ Sp5I responded intensity sent signals superior colliculus were relevant stereotypical motor actions. Synaptic projections from impaired mechanically attacks. Together, these data reveal circuit specifically engaged translating provoke This study reveals respond vibrissae stimuli send inputs colliculus, which are behaviour.

Язык: Английский

Circadian rhythm as a therapeutic target DOI
Wei Ruan, Xiaoyi Yuan, Holger K. Eltzschig

и другие.

Nature Reviews Drug Discovery, Год журнала: 2021, Номер 20(4), С. 287 - 307

Опубликована: Фев. 15, 2021

Язык: Английский

Процитировано

318
Human brain organoids assemble functionally integrated bilateral optic vesicles DOI Creative Commons
Elke Gabriel, Walid Albanna, Giovanni Pasquini

и другие.

Cell stem cell, Год журнала: 2021, Номер 28(10), С. 1740 - 1757.e8

Опубликована: Авг. 17, 2021

Язык: Английский

Процитировано

146
Rhythmic cilia changes support SCN neuron coherence in circadian clock DOI

Hai-Qing Tu,

Sen Li,

Yu-Ling Xu

и другие.

Science, Год журнала: 2023, Номер 380(6648), С. 972 - 979

Опубликована: Июнь 1, 2023

The suprachiasmatic nucleus (SCN) drives circadian clock coherence through intercellular coupling, which is resistant to environmental perturbations. We report that primary cilia are required for coupling among SCN neurons maintain the robustness of internal in mice. Cilia neuromedin S-producing (NMS) exhibit pronounced rhythmicity abundance and length. Genetic ablation ciliogenesis NMS enabled a rapid phase shift under jet-lag conditions. rhythms individual cilia-deficient slices lost their after external Rhythmic changes drive oscillations Sonic Hedgehog (Shh) signaling gene expression. Inactivation Shh phenocopied effects ablation. Thus, cilia-Shh aids coupling.

Язык: Английский

Процитировано

49
Diversity of intrinsically photosensitive retinal ganglion cells: circuits and functions DOI
Marcos L. Aranda, Tiffany M. Schmidt

Cellular and Molecular Life Sciences, Год журнала: 2020, Номер 78(3), С. 889 - 907

Опубликована: Сен. 23, 2020

Язык: Английский

Процитировано

135
Feature Detection by Retinal Ganglion Cells DOI Creative Commons
Daniel Kerschensteiner

Annual Review of Vision Science, Год журнала: 2022, Номер 8(1), С. 135 - 169

Опубликована: Апрель 6, 2022

Retinal circuits transform the pixel representation of photoreceptors into feature representations ganglion cells, whose axons transmit these to brain. Functional, morphological, and transcriptomic surveys have identified more than 40 retinal cell (RGC) types in mice. RGCs extract features varying complexity; some simply signal local differences brightness (i.e., luminance contrast), whereas others detect specific motion trajectories. To understand retina, we need know how give rise diverse RGC representations. A catalog set, turn, is fundamental understanding visual processing Anterograde tracing indicates that innervate 50 areas mouse Current maps connecting brain are rudimentary, as our signals transformed downstream guide behavior. In this article, I review selectivities RGCs, they arise, utilized downstream. Not only knowledge behavioral purpose critical for contributions vision; it can also us most relevant space.

Язык: Английский

Процитировано

70
NPAS4 regulates the transcriptional response of the suprachiasmatic nucleus to light and circadian behavior DOI
Pin Xu, Stefano Berto, Ashwinikumar Kulkarni

и другие.

Neuron, Год журнала: 2021, Номер 109(20), С. 3268 - 3282.e6

Опубликована: Авг. 19, 2021

Язык: Английский

Процитировано

69
Inputs and Outputs of the Mammalian Circadian Clock DOI Creative Commons

Ashley N. Starnes,

Jeff R. Jones

Biology, Год журнала: 2023, Номер 12(4), С. 508 - 508

Опубликована: Март 28, 2023

Circadian rhythms in mammals are coordinated by the central circadian pacemaker, suprachiasmatic nucleus (SCN). Light and other environmental inputs change timing of SCN neural network oscillator, which, turn, sends output signals that entrain daily behavioral physiological rhythms. While much is known about molecular, neuronal, properties itself, circuits linking outside world to rhythmic outputs understudied. In this article, we review our current understanding synaptic non-synaptic onto from SCN. We propose a more complete description connectivity needed better explain how nearly all behaviors processes generated determine how, mechanistically, these disrupted disease or lifestyle.

Язык: Английский

Процитировано

39
Light as a Modulator of Non-Image-Forming Brain Functions—Positive and Negative Impacts of Increasing Light Availability DOI Creative Commons
Islay Campbell, Roya Sharifpour, Gilles Vandewalle

и другие.

Clocks & Sleep, Год журнала: 2023, Номер 5(1), С. 116 - 140

Опубликована: Март 17, 2023

Light use is rising steeply, mainly because of the advent light-emitting diode (LED) devices. LEDs are frequently blue-enriched light sources and may have different impacts on non-image forming (NIF) system, which maximally sensitive to blue-wavelength light. Most importantly, timing LED device widespread, leading novel exposure patterns NIF system. The goal this narrative review discuss multiple aspects that we think should be accounted for when attempting predict how situation will affect impact brain functions. We first cover both image-forming pathways brain. then detail our current understanding human cognition, sleep, alertness, mood. Finally, questions concerning adoption lighting screens, offer new opportunities improve well-being, but also raise concerns about increasing exposure, detrimental health, particularly in evening.

Язык: Английский

Процитировано

30
Axon guidance during mouse central nervous system regeneration is required for specific brain innervation DOI Creative Commons
Céline Delpech, Julia Schaeffer, Noémie Vilallongue

и другие.

Developmental Cell, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Reconstructing functional neuronal circuits is one major challenge of central nervous system repair. Through activation pro-growth signaling pathways, some neurons achieve long-distance axon regrowth. Yet, reconnection has hardly been obtained, as these regenerating axons fail to resume their initial trajectory and reinnervate proper target. Axon guidance considered be active only during development. Here, using the mouse visual system, we show that still in adult brain regenerative conditions. We highlight retinal ganglion cell avoid primary targets, suprachiasmatic nucleus (SCN), due Slit/Robo repulsive signaling. Together with promoting regeneration, silencing vivo enables enter SCN form synapses. The newly formed circuit associated recovery. Our results provide evidence mechanisms are required reconnect specific nuclei.

Язык: Английский

Процитировано

11
The retinal ipRGC-preoptic circuit mediates the acute effect of light on sleep DOI Creative Commons
Ze Zhang, Corinne Beier, Tenley Weil

и другие.

Nature Communications, Год журнала: 2021, Номер 12(1)

Опубликована: Авг. 25, 2021

Light regulates daily sleep rhythms by a neural circuit that connects intrinsically photosensitive retinal ganglion cells (ipRGCs) to the circadian pacemaker, suprachiasmatic nucleus. Light, however, also acutely affects in circadian-independent manner. The circuits involving acute effect of light on remain unknown. Here we uncovered drives this response, independent nucleus, but still through ipRGCs. We show ipRGCs substantially innervate preoptic area (POA) mediate mice. Consistently, activation either POA projecting or light-responsive neurons increased non-rapid eye movement (NREM) without influencing REM sleep. In addition, inhibition blocked effects NREM predominant receive ipRGC input belong corticotropin-releasing hormone subpopulation. Remarkably, are inhibitory and project well-known wakefulness-promoting brain regions, such as tuberomammillary nucleus lateral hypothalamus. Therefore, ipRGC-POA inhibits arousal regions drive light-induced Our findings reveal functional retina-brain is both necessary sufficient for

Язык: Английский

Процитировано

55