High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage

Environmental Science & Technology, Год журнала: 2024, Номер 58(29), С. 12784 - 12822

Опубликована: Июль 10, 2024

In the modern "omics" era, measurement of human exposome is a critical missing link between genetic drivers and disease outcomes. High-resolution mass spectrometry (HRMS), routinely used in proteomics metabolomics, has emerged as leading technology to broadly profile chemical exposure agents related biomolecules for accurate measurement, high sensitivity, rapid data acquisition, increased resolution space. Non-targeted approaches are increasingly accessible, supporting shift from conventional hypothesis-driven, quantitation-centric targeted analyses toward data-driven, hypothesis-generating exposome-wide profiling. However, HRMS-based exposomics encounters unique challenges. New analytical computational infrastructures needed expand analysis coverage through streamlined, scalable, harmonized workflows pipelines that permit longitudinal tracking, retrospective validation, multi-omics integration meaningful health-oriented inferences. this article, we survey literature on state-of-the-art technologies, review current informatic pipelines, provide an up-to-date reference exposomic chemists, toxicologists, epidemiologists, care providers, stakeholders health sciences medicine. We propose efforts benchmark fit-for-purpose platforms expanding space, including gas/liquid chromatography-HRMS (GC-HRMS LC-HRMS), discuss opportunities, challenges, strategies advance burgeoning field exposome.

Язык: Английский

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Legacy and Emerging Plasticizers and Stabilizers in PVC Floorings and Implications for Recycling

Environmental Science & Technology, Год журнала: 2024, Номер 58(4), С. 1894 - 1907

Опубликована: Янв. 19, 2024

Hazardous chemicals in building and construction plastics can lead to health risks due indoor exposure may contaminate recycled materials. We systematically sampled new polyvinyl chloride floorings on the Swiss market (

Язык: Английский

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Untangling the chemical complexity of plastics to improve life cycle outcomes

Nature Reviews Materials, Год журнала: 2024, Номер 9(9), С. 657 - 667

Опубликована: Авг. 13, 2024

Язык: Английский

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Adsorption of PFCs and antibiotics from water using mesoporous silica and amino-functionalized mesoporous silicon materials: A review

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159642 - 159642

Опубликована: Янв. 1, 2025

Язык: Английский

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Sources, distribution, and impacts of emerging contaminants – a critical review on contamination of landfill leachate

Journal of Hazardous Materials Advances, Год журнала: 2025, Номер unknown, С. 100602 - 100602

Опубликована: Янв. 1, 2025

Язык: Английский

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