Role of the gut microbiome in mediating lactose intolerance symptoms

Gut, Год журнала: 2021, Номер 71(1), С. 215 - 217

Опубликована: Март 18, 2021

Misselwitz et al recently reviewed the multifactorial aspects of lactose intolerance (LI).1 Their work highlights known effects genetic makeup and dietary patterns in occurrence gastrointestinal symptoms LI individuals. The authors define as complaints on exposure discuss wide variety among patients.1 Regarding metabolism, mention influence gut microbiome, particular that Bifidobacterium or other lactose-fermenting bacteria are reported to affect levels gut. However, impact microbiome gut-related remains unclear. We previously observed abundance adult human depends interaction between variants dairy intake.2 This observation complements findings indicating a mutual relationship host metabolism.3–8 these earlier analyses did not consider symptoms. inspired us investigate whether interplay consumption affects individuals. We analysed data complaints, genetics, diet 959 participants Lifelines-DEEP Dutch population cohort. We classified status based presence functional variant rs4988235 …

Язык: Английский

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Geography and elevation as drivers of cloacal microbiome assemblages of a passerine bird distributed across Sulawesi, Indonesia

Animal Microbiome, Год журнала: 2023, Номер 5(1)

Опубликована: Янв. 16, 2023

Abstract Background Empirical field studies allow us to view how ecological and environmental processes shape the biodiversity of our planet, but collecting samples in situ creates inherent challenges. The majority empirical vertebrate gut microbiome research compares multiple host species against abiotic biotic factors, increasing potential for confounding variables. To minimize these we focus on a single passerine bird found throughout geologically complex island Sulawesi, Indonesia. We assessed effects two geographic Areas Endemism (AOEs) elevation, as well sex microbiota assemblages Sulawesi Babbler, Pellorneum celebense, from three different mountains across island. Using cloacal swabs, high-throughput-amplicon sequencing, statistical models, identified core determined signal factors microbial composition. Results five most prevalent bacterial phyla within P. celebense were Proteobacteria (32.6%), Actinobacteria (25.2%), Firmicutes (22.1%), Bacteroidetes (8.7%), Plantomycetes (2.6%). These results are similar those prior passeriform microbiomes. Overall, diversity decreased elevation increased, irrespective or AOE. A ASV Clostridium was enriched higher samples, while lower with genera Perlucidibaca (Family Moraxellaceae ), Lachnoclostridium Lachnospiraceae an unidentified Family Pseudonocardiaceae . Conclusions While families recovered here consistent other studies, decreases increases has only been seen non-avian hosts. Additionally, increased abundance at high elevations suggests response oxygen levels. This study emphasizes importance incorporating models such research, is first describe avian Sulawesi.

Язык: Английский

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Characterization of gut dominant microbiota in obese patients with nonalcoholic fatty liver disease

Frontiers in Cellular and Infection Microbiology, Год журнала: 2023, Номер 13

Опубликована: Янв. 23, 2023

In obese patients, non-alcoholic fatty liver (NAFLD) is common. However, whether there a connection between the gut microbiota and onset of NAFLD in people yet unknown. Using quantitative real-time PCR, feces eligible 181 individuals was identified to compare differences obesity with simple obesity. According findings, dominant similar Nonetheless, compared group, quantity Faecalibacterium prausnitzii colonies much lower group. Bacteroides were present greater than 65% both groups. , Clostridium leptum butyricum accounted for more 80% cases whereas F. We look potential contributing variables obesity-related prevention measures people. Based on multi-factor logistic regression analysis, lymphocytes may be risk factor while protective factor. Additionally, positively impacted by Eubacterium rectale adversely Enterobacteriaceae. Notably, help determine patients would develop NAFLD.

Язык: Английский

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Supplementation with Lactobacillus helveticus NS8 alleviated behavioral, neural, endocrine, and microbiota abnormalities in an endogenous rat model of depression

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Сен. 13, 2024

Major depressive disorder is a condition involving microbiota-gut-brain axis dysfunction. Increasing research aims to improve depression through gut microbiota regulation, including interventions such as probiotics, prebiotics, and fecal transplants. However, most focuses on exogenous induced by chronic stress or drugs, with less attention given endogenous depression. Additionally, mycobiota in significantly than that bacteria.

Язык: Английский

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Les humains ont-ils coévolué avec le microbiote intestinal ?

médecine/sciences, Год журнала: 2025, Номер 41(1), С. 53 - 61

Опубликована: Янв. 1, 2025

Le microbiote intestinal joue un rôle clef pour la santé. Alors que les mécanismes qui déterminent ses effets commencent à être élucidés, son évolution est peu connue. Des questions telles « le évolue-t-il et quel rythme ? », quelle origine ou avons-nous coévolué avec nos bactéries intestinales sont explorées. À court terme, microbes évoluent en réponse des modifications de l’environnement, comme régime alimentaire leur hôte. Sur une échelle temps longue, l’évolution au sein d’un individu contrebalancée par échanges provenant d’autres individus. Ainsi, si intestinaux ont probablement évolué dans populations, plupart longue histoire d’échanges entre populations. Savoir du depuis dizaines milliers d’années a facilité adaptations humaines reste question ouverte fondamentale.

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