The Plant Cell,
Год журнала:
2021,
Номер
34(1), С. 72 - 102
Опубликована: Сен. 13, 2021
As
scientists,
we
are
at
least
as
excited
about
the
open
questions-the
things
do
not
know-as
discoveries.
Here,
asked
15
experts
to
describe
most
compelling
questions
in
plant
cell
biology.
These
their
questions:
How
organelle
identity,
domains,
and
boundaries
maintained
under
continuous
flux
of
vesicle
trafficking
membrane
remodeling?
Is
cortical
microtubule
cytoskeleton
a
mechanosensory
apparatus?
cellular
pathways
wall
synthesis,
assembly,
modification,
integrity
sensing
linked
plants?
Why
plasmodesmata
close?
there
retrograde
signaling
from
vacuoles
nucleus?
root
cells
accommodate
fungal
endosymbionts?
What
is
role
edges
morphogenesis?
division
site
determined?
emergent
effects
polyploidy
on
biology
cell,
how
any
such
"rules"
conditioned
by
type?
Can
mechanical
forces
trigger
new
fates
does
single
differentiated
somatic
reprogram
gain
pluripotency?
polarity
develop
de-novo
isolated
cells?
spectrum
functions
for
membraneless
organelles
intrinsically
disordered
proteins?
plants
deal
with
internal
noise?
order
emerge
propagate
organs
organisms
complex
dynamical
processes?
We
hope
you
find
discussions
these
thought
provoking
inspiring.
Experimental & Molecular Medicine,
Год журнала:
2021,
Номер
53(10), С. 1529 - 1538
Опубликована: Окт. 1, 2021
Abstract
Circadian
clocks
are
ubiquitous
timing
mechanisms
that
generate
approximately
24-h
rhythms
in
cellular
and
bodily
functions
across
nearly
all
living
species.
These
internal
clock
systems
enable
organisms
to
anticipate
respond
daily
changes
their
environment
a
timely
manner,
optimizing
temporal
physiology
behaviors.
Dysregulation
of
circadian
by
genetic
environmental
risk
factors
increases
susceptibility
multiple
diseases,
particularly
cancers.
A
growing
number
studies
have
revealed
dynamic
crosstalk
between
cancer
pathways,
providing
mechanistic
insights
into
the
therapeutic
utility
treatment.
This
review
will
discuss
roles
pathogenesis,
highlighting
recent
advances
chronotherapeutic
approaches
for
improved
Journal of Sleep Research,
Год журнала:
2022,
Номер
31(4)
Опубликована: Май 3, 2022
Summary
The
two‐process
model
serves
as
a
major
conceptual
framework
in
sleep
science.
Although
dating
back
more
than
four
decades,
it
has
not
lost
its
relevance
for
research
today.
Retracing
origins,
I
describe
how
animal
experiments
aimed
at
exploring
the
oscillators
driving
circadian
sleep–wake
rhythm
led
to
recognition
of
gradients
states
within
daily
period.
Advances
signal
analysis
revealed
that
level
slow‐wave
activity
non‐rapid
eye
movement
electroencephalogram
is
high
beginning
12‐light
period
and
then
declines.
After
deprivation,
enhanced.
By
scheduling
recovery
animal's
period,
conflict
between
sleep–wake‐dependent
influence
resulted
two‐stage
pattern.
These
provided
basis
first
version
model.
Sleep
deprivation
humans
showed
decline
during
exponential.
posits
homeostatic
process
(Process
S)
interacts
with
controlled
by
pacemaker
C).
At
present,
facets
regulation
are
being
investigated
synaptic
well
transcriptome
proteome
domains.
notion
been
extended
from
global
phenomenon
local
representations,
while
master
supplemented
multiple
peripheral
oscillators.
original
interpretation
emergence
may
be
viewed
an
escape
rigid
control
imposed
still
upheld.
Physiological Reviews,
Год журнала:
2023,
Номер
103(3), С. 1693 - 1787
Опубликована: Янв. 5, 2023
Human
skeletal
muscle
demonstrates
remarkable
plasticity,
adapting
to
numerous
external
stimuli
including
the
habitual
level
of
contractile
loading.
Accordingly,
function
and
exercise
capacity
encompass
a
broad
spectrum,
from
inactive
individuals
with
low
levels
endurance
strength
elite
athletes
who
produce
prodigious
performances
underpinned
by
pleiotropic
training-induced
muscular
adaptations.
Our
current
understanding
signal
integration,
interpretation,
output
coordination
cellular
molecular
mechanisms
that
govern
plasticity
across
this
continuum
is
incomplete.
As
such,
training
methods
their
application
largely
rely
on
“trial-and-error”
approach,
experience
practices
successful
coaches
often
providing
bases
for
“post
hoc”
scientific
enquiry
research.
This
review
provides
synopsis
morphological
functional
changes
along
underlying
adaptation
endurance-
resistance-based
training.
These
traits
are
placed
in
context
innate
genetic
interindividual
differences
performance,
special
consideration
given
aging
athletes.
Collectively,
we
provide
comprehensive
overview
response
different
modes
how
such
adaptations
translate
“molecules
medals.”
Journal of Hematology & Oncology,
Год журнала:
2022,
Номер
15(1)
Опубликована: Март 4, 2022
The
circadian
rhythm
is
an
evolutionarily
conserved
time-keeping
system
that
comprises
a
wide
variety
of
processes
including
sleep-wake
cycles,
eating-fasting
and
activity-rest
coordinating
the
behavior
physiology
all
organs
for
whole-body
homeostasis.
Acute
disruption
may
lead
to
transient
discomfort,
whereas
long-term
irregular
will
result
in
dysfunction
organism,
therefore
increasing
risks
numerous
diseases
especially
cancers.
Indeed,
both
epidemiological
experimental
evidence
has
demonstrated
intrinsic
link
between
dysregulated
cancer.
Accordingly,
rapidly
understanding
molecular
mechanisms
rhythms
opening
new
options
cancer
therapy,
possibly
by
modulating
clock.
In
this
review,
we
first
describe
general
regulators
their
functions
on
addition,
provide
insights
into
underlying
how
several
types
(including
sleep-wake,
eating-fasting,
activity-rest)
can
drive
progression,
which
expand
our
development
from
clock
perspective.
Moreover,
also
summarize
potential
applications
treatment,
optional
therapeutic
strategy
patients.
Cell Reports,
Год журнала:
2023,
Номер
42(1), С. 111982 - 111982
Опубликована: Янв. 1, 2023
Cellular
circadian
clocks
direct
a
daily
transcriptional
program
that
supports
homeostasis
and
resilience.
Emerging
evidence
has
demonstrated
age-associated
changes
in
functions.
To
define
age-dependent
at
the
systems
level,
we
profile
transcriptome
hypothalamus,
lung,
heart,
kidney,
skeletal
muscle,
adrenal
gland
three
age
groups.
We
find
tissue-specific
clock
output
changes.
Aging
reduces
number
of
rhythmically
expressed
genes
(REGs),
indicative
weakened
control.
REGs
are
enriched
for
hallmarks
aging,
adding
another
dimension
to
our
understanding
aging.
Analyzing
differential
gene
expression
within
tissue
four
different
times
day
identifies
distinct
clusters
differentially
(DEGs).
Increased
variability
across
is
common
feature
aged
tissues.
This
analysis
extends
landscape
aging
highlights
impact
on
function
temporal
expression.
Cell Metabolism,
Год журнала:
2023,
Номер
35(10), С. 1704 - 1721.e6
Опубликована: Авг. 21, 2023
Circadian
disruptions
impact
nearly
all
people
with
Alzheimer's
disease
(AD),
emphasizing
both
their
potential
role
in
pathology
and
the
critical
need
to
investigate
therapeutic
of
circadian-modulating
interventions.
Here,
we
show
that
time-restricted
feeding
(TRF)
without
caloric
restriction
improved
key
components
including
behavioral
timing,
pathology,
hippocampal
transcription,
memory
two
transgenic
(TG)
mouse
models
AD.
We
found
TRF
had
remarkable
capability
simultaneously
reducing
amyloid
deposition,
increasing
Aβ42
clearance,
improving
sleep
memory,
normalizing
daily
transcription
patterns
multiple
genes,
those
associated
AD
neuroinflammation.
Thus,
our
study
unveils
for
first
time
pleiotropic
nature
timed
on
AD,
which
has
far-reaching
effects
beyond
metabolism,
ameliorating
neurodegeneration
misalignment
circadian
rhythmicity.
Since
can
substantially
modify
trajectory,
this
intervention
immediate
translational
potential,
addressing
urgent
demand
accessible
approaches
reduce
or
halt
progression.
Science,
Год журнала:
2024,
Номер
384(6695), С. 563 - 572
Опубликована: Май 2, 2024
A
molecular
clock
network
is
crucial
for
daily
physiology
and
maintaining
organismal
health.
We
examined
the
interactions
importance
of
intratissue
networks
in
muscle
tissue
maintenance.
In
arrhythmic
mice
showing
premature
aging,
we
created
a
basic
module
involving
central
peripheral
(muscle)
clock.
Reconstituting
brain-muscle
sufficient
to
preserve
fundamental
homeostatic
functions
prevent
aging.
However,
achieving
whole
requires
contributions
from
other
clocks.
Mechanistically,
acts
as
gatekeeper,
selectively
suppressing
detrimental
signals
while
integrating
important
functions.
Our
research
reveals
interplay
between
clocks
function
underscores
impact
eating
patterns
on
these
interactions.
