
Nature reviews. Immunology, Год журнала: 2021, Номер 21(4), С. 245 - 256
Опубликована: Март 15, 2021
Язык: Английский
Nature reviews. Immunology, Год журнала: 2021, Номер 21(4), С. 245 - 256
Опубликована: Март 15, 2021
Язык: Английский
Nature Reviews Drug Discovery, Год журнала: 2021, Номер 20(7), С. 551 - 569
Опубликована: Май 17, 2021
Язык: Английский
Процитировано
794Nature Reviews Microbiology, Год журнала: 2022, Номер 20(5), С. 270 - 284
Опубликована: Март 30, 2022
Язык: Английский
Процитировано
722Cell, Год журнала: 2021, Номер 184(7), С. 1671 - 1692
Опубликована: Фев. 17, 2021
Язык: Английский
Процитировано
671Nature Medicine, Год журнала: 2021, Номер 27(1), С. 28 - 33
Опубликована: Янв. 1, 2021
Язык: Английский
Процитировано
642The Lancet, Год журнала: 2020, Номер 396(10262), С. 1595 - 1606
Опубликована: Окт. 13, 2020
Язык: Английский
Процитировано
610Frontiers in Microbiology, Год журнала: 2021, Номер 11
Опубликована: Янв. 15, 2021
The emergence and spread of infectious diseases with pandemic potential occurred regularly throughout history. Major pandemics epidemics such as plague, cholera, flu, severe acute respiratory syndrome coronavirus (SARS-CoV) Middle East (MERS-CoV) have already afflicted humanity. world is now facing the new disease 2019 (COVID-19) pandemic. Many leading to are caused by zoonotic pathogens that were transmitted humans due increased contacts animals through breeding, hunting global trade activities. understanding mechanisms transmission allowed establishment methods prevent control infections. During centuries, implementation public health measures isolation, quarantine border helped contain maintain structure society. In absence pharmaceutical interventions, these containment still been used nowadays COVID-19 Global surveillance programs water-borne pathogens, vector-borne spillovers at animal-human interface prime importance rapidly detect threats. Novel technologies for rapid diagnostic testing, contact tracing, drug repurposing, biomarkers severity well platforms development production vaccines needed an effective response in case pandemics.
Язык: Английский
Процитировано
592Immunity, Год журнала: 2021, Номер 54(3), С. 437 - 453
Опубликована: Март 1, 2021
Язык: Английский
Процитировано
587Nature reviews. Immunology, Год журнала: 2021, Номер 21(8), С. 475 - 484
Опубликована: Июль 1, 2021
Язык: Английский
Процитировано
548Science Immunology, Год журнала: 2021, Номер 6(62)
Опубликована: Авг. 10, 2021
Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found about 10% patients with critical COVID-19 pneumonia, but not subjects asymptomatic infections. We detect auto-Abs 100-fold lower, more physiological, (100 pg/mL, 1/10 dilutions plasma) 13.6% 3,595 COVID-19, including 21% 374 > 80 years, and 6.5% 522 severe COVID-19. These antibodies also detected 18% the 1,124 deceased (aged 20 days-99 years; mean: 70 years). Moreover, another 1.3% 0.9% have IFN-β. show, a sample 34,159 uninfected from general population, that present 0.18% individuals between 18 69 1.1% 79 3.4% >80 years. proportion carrying lower is greater subsample 10,778 individuals: 1% <70 2.3% 6.3% By contrast, IFN-β do become frequent age. Auto-Abs type I IFNs predate SARS-CoV-2 infection sharply increase prevalence after age They account for 20% both cases over-80s, total fatal cases.
Язык: Английский
Процитировано
521Nature Immunology, Год журнала: 2022, Номер 23(2), С. 165 - 176
Опубликована: Фев. 1, 2022
Язык: Английский
Процитировано
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