Cells,
Год журнала:
2023,
Номер
12(9), С. 1296 - 1296
Опубликована: Май 2, 2023
Senescent
cell
accumulation
has
been
observed
in
age-associated
diseases
including
cardiovascular
diseases.
cells
lack
proliferative
capacity
and
secrete
senescence-associated
secretory
phenotype
(SASP)
factors
that
may
cause
or
worsen
many
Therapies
targeting
senescent
cells,
especially
senolytic
drugs
selectively
induce
removal,
have
shown
to
delay,
prevent,
alleviate,
treat
multiple
preclinical
models.
Some
clinical
trials
already
completed
are
underway
for
a
number
of
geriatric
syndromes.
Understanding
how
cellular
senescence
affects
the
various
types
system,
such
as
endothelial
vascular
smooth
muscle
fibroblasts,
immune
progenitor
cardiomyocytes,
is
important
facilitate
translation
senotherapeutics
into
interventions.
This
review
highlights:
(1)
characteristics
their
involvement
diseases,
focusing
on
aforementioned
types,
(2)
evidence
about
other
senotherapeutics,
(3)
future
path
potential
Journal of Clinical Investigation,
Год журнала:
2022,
Номер
132(15)
Опубликована: Июль 31, 2022
Cellular
senescence
is
a
hallmark
of
aging
defined
by
stable
exit
from
the
cell
cycle
in
response
to
cellular
damage
and
stress.
Senescent
cells
(SnCs)
can
develop
characteristic
pathogenic
senescence-associated
secretory
phenotype
(SASP)
that
drives
secondary
disrupts
tissue
homeostasis,
resulting
loss
repair
regeneration.
The
use
transgenic
mouse
models
which
SnCs
be
genetically
ablated
has
established
key
role
for
driving
age-related
disease.
Importantly,
senotherapeutics
have
been
developed
pharmacologically
eliminate
SnCs,
termed
senolytics,
or
suppress
SASP
other
markers
senescence,
senomorphics.
Based
on
extensive
preclinical
studies
as
well
small
clinical
trials
demonstrating
benefits
senotherapeutics,
multiple
are
under
way.
This
Review
discusses
diseases,
strategies
target
approaches
discover
advances
senolytics.
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(23), С. 13173 - 13173
Опубликована: Дек. 6, 2021
Cellular
senescence
entails
a
state
of
an
essentially
irreversible
proliferative
arrest
in
which
cells
remain
metabolically
active
and
secrete
range
pro-inflammatory
proteolytic
factors
as
part
the
senescence-associated
secretory
phenotype.
There
are
different
types
senescent
cells,
can
be
induced
response
to
many
DNA
damage
signals.
Senescent
accumulate
tissues
organs
where
they
have
distinct
physiological
pathological
functions.
Despite
this
diversity,
all
must
able
survive
nondividing
while
protecting
themselves
from
positive
feedback
loops
linked
constant
activation
response.
This
capacity
requires
changes
core
cellular
programs.
Understanding
how
cell
undergo
extensive
their
transcriptional
programs,
metabolism,
heterochromatin
patterns,
structures
induce
common
is
crucial
preventing
cancer
development/progression
improving
health
during
aging.
In
review,
we
discuss
continuously
evolve
after
initial
highlight
unifying
features
that
define
state.
