Genetic and neural mechanisms of sleep disorders in children with autism spectrum disorder: a review DOI Creative Commons
Ji Qi, Sijia Li,

Jun-Bo Zhao

и другие.

Frontiers in Psychiatry, Год журнала: 2023, Номер 14

Опубликована: Май 2, 2023

Background The incidence of sleep disorders in children with autism spectrum disorder (ASD) is very high. Sleep can exacerbate the development ASD and impose a heavy burden on families society. pathological mechanism complex, but gene mutations neural abnormalities may be involved. Methods In this review, we examined literature addressing genetic mechanisms ASD. databases PubMed Scopus were searched for eligible studies published between 2013 2023. Results Prolonged awakenings caused by following processes. Mutations MECP2, VGAT SLC6A1 genes decrease GABA inhibition neurons locus coeruleus, leading to hyperactivity noradrenergic prolonged HRH1, HRH2 , HRH3 heighten expression histamine receptors posterior hypothalamus, potentially intensifying histamine’s ability promote arousal. KCNQ3 PCDH10 cause atypical modulation amygdala impact orexinergic neurons, causing hyperexcitability hypothalamic orexin system. AHI1 ARHGEF10 UBE3A SLC6A3 affect dopamine synthesis, catabolism, reuptake processes, which elevate concentrations midbrain. Secondly, non-rapid eye movement closely related lack butyric acid, iron deficiency dysfunction thalamic reticular nucleus induced PTCHD1 alterations. Thirdly, HTR2A, SLC6A4 MAOA, MAOB TPH2 VMATs SHANK3, CADPS2 induce structural functional dorsal raphe (DRN) amygdala, disturb REM sleep. addition, melatonin levels ASMT MTNR1A MTNR1B mutations, along basal forebrain cholinergic lead abnormal sleep–wake rhythm transitions. Conclusion Our review revealed that circuits are strongly correlated Exploring underlying pathology significant further therapy.

Язык: Английский

Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer’s disease DOI Creative Commons
Christopher D. Morrone, Radha Raghuraman, S. Abid Hussaini

и другие.

Molecular Neurodegeneration, Год журнала: 2023, Номер 18(1)

Опубликована: Апрель 21, 2023

Abstract Failed proteostasis is a well-documented feature of Alzheimer’s disease, particularly, reduced protein degradation and clearance. However, the contribution failed to neuronal circuit dysfunction an emerging concept in neurodegenerative research will prove critical understanding cognitive decline. Our objective convey disease progression with growing evidence for bidirectional relationship sleep disruption failure. Proteostasis tauopathy disrupts neurons that regulate sleep–wake cycle, which presents behavior as impaired slow wave rapid eye movement patterns. Subsequent loss further impairs Sleep defined seen early many disorders contributes memory impairments disease. Canonical pathological hallmarks, β-amyloid, tau, directly disrupt sleep, neurodegeneration locus coeruleus, hippocampal hypothalamic from tau proteinopathy causes circuitry sleep. Acting positive-feedback-loop, circadian rhythm then increase spread β-amyloid through proteasome, autophagy, unfolded response glymphatic This phenomenon extends beyond interactions impairment homeostasis TDP-43, α-synuclein, FUS, huntingtin proteins, implicating important consideration array diseases cases mixed neuropathology. Critically, dynamics this interaction environment are not fully elucidated deserving discussion research. Finally, we propose sleep-enhancing therapeutics potential interventions promoting healthy proteostasis, including clearance, mechanistically linking these processes. With clinical preclinical research, dynamic diagnostic therapeutic framework, informing precise single- combinatorial-treatments other brain disorders. Graphical

Язык: Английский

Процитировано

27
The role of the hippocampus in the consolidation of emotional memories during sleep DOI Open Access
Éléonore Pronier, Juan Facundo Morici, Gabrielle Girardeau

и другие.

Trends in Neurosciences, Год журнала: 2023, Номер 46(11), С. 912 - 925

Опубликована: Сен. 14, 2023

Язык: Английский

Процитировано

24
Vitamin B6 alleviates chronic sleep deprivation-induced hippocampal ferroptosis through CBS/GSH/GPX4 pathway DOI Open Access
Man Yuan, Rui Wang,

Tieqiang Sun

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 174, С. 116547 - 116547

Опубликована: Апрель 9, 2024

Several studies have found that sleep deprivation (SD) can lead to neuronal ferroptosis and affect hippocampal function. However, there are currently no effective interventions. Vitamin B6 is a co-factor for key enzymes in the transsulfuration pathway which critical maintaining cell growth presence of cysteine deprivation. The results showed SD inhibited cystine-glutamate antiporter light chain subunit xCT protein expression caused deficiency, reduced synthesis glutathione (GSH) trigger ferroptosis. Nissl staining further revealed significant loss shrinkage CA1 CA3 regions hippocampus mice. Typical ferroptotic indicators characterized by lipid peroxidation iron accumulation were after As expected, vitamin could alleviate upregulating cystathionine beta-synthase (CBS) pathway, thereby replenishing intracellular deficient GSH restoring GPX4. Similar anti-ferroptotic effects demonstrated HT-22 cells treated with activator erastin. Furthermore, had inhibitory effect on erastin-induced CBS-knockout HT22 cells. Our findings suggested chronic disrupting cyst(e)ine/GSH/GPX4 axis. alleviated deprivation-induced enhancing CBS pathway.

Язык: Английский

Процитировано

9
Amygdalo-cortical dialogue underlies memory enhancement by emotional association DOI Creative Commons
Yoshihito Saito, Yuma Osako, Maya Odagawa

и другие.

Neuron, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Cognitive neuroscience perspective on memory: overview and summary DOI Creative Commons

Sruthi Sridhar,

Abdulrahman Khamaj, Manish Kumar Asthana

и другие.

Frontiers in Human Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Июль 26, 2023

This paper explores memory from a cognitive neuroscience perspective and examines associated neural mechanisms. It the different types of memory: working, declarative, non-declarative, brain regions involved in each type. The highlights role regions, such as prefrontal cortex working hippocampus declarative memory. also mechanisms that underlie formation consolidation memory, including importance sleep linking new memories to existing schemata. two processes: cellular system consolidation. Cellular is process stabilizing information by strengthening synaptic connections. System models suggest are initially stored gradually consolidated into neocortex over time. involves hippocampal-neocortical binding incorporating newly acquired medial temporal lobe its involvement autobiographical Further, discusses relationship between episodic semantic hippocampus. Finally, underscores need for further research neurobiological underlying non-declarative particularly conditioning. Overall, provides comprehensive overview processes

Язык: Английский

Процитировано

21
What is sleep exactly? Global and local modulations of sleep oscillations all around the clock DOI Creative Commons
Thomas Andrillon, Delphine Oudiette

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 155, С. 105465 - 105465

Опубликована: Ноя. 15, 2023

Wakefulness, non-rapid eye-movement (NREM) and rapid (REM) sleep differ from each other along three dimensions: behavioral, phenomenological, physiological. Although these dimensions often fluctuate in step, they can also dissociate. The current paradigm that views as made of global NREM REM states fail to account for dissociations. This conundrum be dissolved by stressing the existence significance local regulation sleep. We will review evidence animals humans, healthy pathological brains, showing different forms consequences on behavior, cognition, subjective experience. Altogether, we argue notion provides a unified host phenomena: dreaming sleep, parasomnias, intrasleep responsiveness, inattention mind wandering wakefulness. Yet, physiological origins or its putative functions remain unclear. Exploring further could provide unique novel perspective how why

Язык: Английский

Процитировано

19
The little brain and the seahorse: Cerebellar-hippocampal interactions DOI Creative Commons
Jessica M. Froula, Shayne D. Hastings, Esther Krook‐Magnuson

и другие.

Frontiers in Systems Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Март 23, 2023

There is a growing appreciation for the cerebellum beyond its role in motor function and accumulating evidence that hippocampus interact across range of brain states behaviors. Acute chronic manipulations, simultaneous recordings, imaging studies together indicate coordinated coactivation bidirectional functional connectivity relevant various physiological functions, including spatiotemporal processing. This likely supported by multiple circuit paths. It also important temporal lobe epilepsy: impacted seizures epilepsy, modulation cerebellar circuitry can be an effective strategy to inhibit hippocampal seizures. review highlights some recent key hippobellum literature.

Язык: Английский

Процитировано

17
A medullary hub for controlling REM sleep and pontine waves DOI Creative Commons
Amanda L. Schott, Justin Baik, Shinjae Chung

и другие.

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Июль 3, 2023

Abstract Rapid-eye-movement (REM) sleep is a distinct behavioral state associated with vivid dreaming and memory processing. Phasic bursts of electrical activity, measurable as spike-like pontine (P)-waves, are hallmark REM implicated in consolidation. However, the brainstem circuits regulating P-waves, their interactions generating sleep, remain largely unknown. Here, we show that an excitatory population dorsomedial medulla (dmM) neurons expressing corticotropin-releasing-hormone (CRH) regulates both P-waves mice. Calcium imaging showed dmM CRH selectively activated during recruited opto- chemogenetic experiments revealed this promotes sleep. Chemogenetic manipulation also induced prolonged changes P-wave frequency, while brief optogenetic activation reliably triggered along transiently accelerated theta oscillations electroencephalogram (EEG). Together, these findings anatomically functionally delineate common medullary hub for regulation P-waves.

Язык: Английский

Процитировано

17
Association of Disrupted Delta Wave Activity During Sleep With Long-Term Cardiovascular Disease and Mortality DOI
Sizhi Ai, Shuo Ye, Guohua Li

и другие.

Journal of the American College of Cardiology, Год журнала: 2024, Номер 83(17), С. 1671 - 1684

Опубликована: Апрель 1, 2024

Язык: Английский

Процитировано

7
Mystery of the memory engram: History, current knowledge, and unanswered questions DOI Creative Commons
Matthew R. Lopez,

S.M.H. Wasberg,

Celia Gagliardi

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 159, С. 105574 - 105574

Опубликована: Фев. 6, 2024

The quest to understand the memory engram has intrigued humans for centuries. Recent technological advances, including genetic labelling, imaging, optogenetic and chemogenetic techniques, have propelled field of research forward. These tools enabled researchers create erase components. While these innovative techniques yielded invaluable insights, they often focus on specific elements trace. Genetic labelling may rely a particular immediate early gene as marker activity, optogenetics activate or inhibit one type neuron, imaging capture activity snapshots in given brain region at times. Yet, memories are multifaceted, involving diverse arrays neuronal subpopulations, circuits, regions that work concert create, store, retrieve information. Consideration contributions both excitatory inhibitory neurons, micro macro circuits across regions, dynamic nature active ensembles, representational drift is crucial comprehensive understanding complex memory.

Язык: Английский

Процитировано

6