The Innovation,
Год журнала:
2024,
Номер
5(2), С. 100586 - 100586
Опубликована: Фев. 3, 2024
The
chemical
recycling
of
polyolefin
presents
a
considerable
challenge,
especially
as
upcycling
methods
struggle
with
the
reality
that
plastic
wastes
typically
consist
mixtures
polyethylene
(PE),
polystyrene
(PS),
and
polypropylene
(PP).
We
report
catalytic
aerobic
oxidative
approach
for
polyolefins
corresponding
carboxylic
acids
product.
This
method
encompasses
three
key
innovations.
First,
it
operates
under
atmospheric
pressure
mild
conditions,
using
O
Science,
Год журнала:
2023,
Номер
381(6653), С. 75 - 81
Опубликована: Июль 6, 2023
Skeletal
ring
enlargement
is
gaining
renewed
interest
in
synthetic
chemistry
and
has
recently
focused
on
insertion
of
one
or
two
atoms.
Strategies
for
heterocyclic
expansion
through
small-ring
remain
elusive,
although
they
would
lead
to
the
efficient
formation
bicyclic
products.
Here,
we
report
a
photoinduced
dearomative
thiophenes
by
bicyclo[1.1.0]butanes
produce
eight-membered
rings
under
mild
conditions.
The
value,
broad
functional-group
compatibility,
excellent
chemo-
regioselectivity
were
demonstrated
scope
evaluation
product
derivatization.
Experimental
computational
studies
point
toward
photoredox-induced
radical
pathway.
Helvetica Chimica Acta,
Год журнала:
2023,
Номер
106(3)
Опубликована: Янв. 13, 2023
Abstract
Skeletal
editing
involves
making
specific
point‐changes
to
the
core
of
a
molecule
through
selective
insertion,
deletion
or
exchange
atoms.
It
thus
represents
potentially
powerful
strategy
for
step‐economic
modification
complex
substrates
and
is
perfect
complement
methods
such
as
C−H
functionalization
that
target
molecular
periphery.
Given
their
ubiquity
in
biologically
active
compounds,
ability
perform
skeletal
on
–
therefore
interconvert
between
aromatic
heterocycles
especially
valuable.
This
review
summarizes
both
recent
key
historical
examples
applied
interconversion
rings;
we
anticipate
it
will
serve
highlight
not
only
innovative
enabling
nature
current
methods,
but
also
tremendous
opportunities
still
exist
field.
Journal of the American Chemical Society,
Год журнала:
2022,
Номер
144(48), С. 22309 - 22315
Опубликована: Ноя. 28, 2022
A
method
for
the
conversion
of
pyrimidines
into
pyrazoles
by
a
formal
carbon
deletion
has
been
achieved
guided
computational
analysis.
The
pyrimidine
heterocycle
is
most
common
diazine
in
FDA-approved
drugs,
and
are
diazole.
An
efficient
to
convert
would
therefore
be
valuable
leveraging
chemistries
unique
access
diversified
pyrazoles.
One
known,
though
it
proceeds
low
yields
requires
harsh
conditions.
transformation
reported
here
under
milder
conditions,
tolerates
wide
range
functional
groups,
enables
simultaneous
regioselective
introduction
N-substitution
on
resulting
pyrazole.
Key
success
this
one-carbon
room-temperature
triflylation
core,
followed
hydrazine-mediated
skeletal
remodeling.
Journal of the American Chemical Society,
Год журнала:
2022,
Номер
144(49), С. 22433 - 22439
Опубликована: Ноя. 30, 2022
Developing
strategies
enabling
the
modification
of
underlying
molecular
frameworks
facilitates
access
to
underexplored
chemical
spaces.
Skeletal
editing
is
an
emerging
technology
for
late-stage
diversification
bioactive
molecules.
However,
current
state
this
knowledge
remains
undeveloped.
This
work
describes
a
simple
protocol
that
"inserts"
nitrogen
atom
into
arylcycloalkenes
form
corresponding
N-heterocycles.
The
use
inexpensive
cobalt
catalyst
under
aqueous
and
open-air
conditions
makes
very
practical.
Examples
compounds
pharmaceutical
interest
complex
fused
ring
further
demonstrated
potentially
broad
applicability
methodology.
Chemical Science,
Год журнала:
2023,
Номер
14(11), С. 2954 - 2959
Опубликована: Янв. 1, 2023
We
report
a
convenient
protocol
for
nitrogen
atom
insertion
into
indenes
to
afford
isoquinolines.
The
strategy
further
enables
the
synthesis
of
pyridines
from
cyclopentadienes
and
facile
access
15
N
labelled
Nature Chemistry,
Год журнала:
2024,
Номер
16(5), С. 741 - 748
Опубликована: Янв. 18, 2024
Abstract
Skeletal
editing
is
a
straightforward
synthetic
strategy
for
precise
substitution
or
rearrangement
of
atoms
in
core
ring
structures
complex
molecules;
it
enables
quick
diversification
compounds
that
not
possible
by
applying
peripheral
strategies.
Previously
reported
skeletal
common
arenes
mainly
relies
on
carbene-
nitrene-type
insertion
reactions
rearrangements.
Although
powerful,
efficient
and
applicable
to
late-stage
heteroarene
structure
modification,
these
strategies
cannot
be
used
pyridines.
Here
we
report
the
direct
pyridines
through
atom-pair
swap
from
CN
CC
generate
benzenes
naphthalenes
modular
fashion.
Specifically,
use
sequential
dearomatization,
cycloaddition
rearomatizing
retrocycloaddition
one-pot
sequence
transform
parent
into
bearing
diversified
substituents
at
specific
sites,
as
defined
reaction
components.
Applications
pyridine
cores
several
drugs
are
demonstrated.
Chemical Reviews,
Год журнала:
2023,
Номер
123(22), С. 12313 - 12370
Опубликована: Ноя. 9, 2023
Late-stage
functionalization
(LSF)
introduces
functional
group
or
structural
modification
at
the
final
stage
of
synthesis
natural
products,
drugs,
and
complex
compounds.
It
is
anticipated
that
late-stage
would
improve
drug
discovery's
effectiveness
efficiency
hasten
creation
various
chemical
libraries.
Consequently,
products
a
productive
technique
to
produce
product
derivatives,
which
significantly
impacts
biology
development.
Carbon-carbon
bonds
make
up
fundamental
framework
organic
molecules.
Compared
with
carbon-carbon
bond
construction,
activation
can
directly
enable
molecular
editing
(deletion,
insertion,
atoms
groups
atoms)
provide
more
efficient
accurate
synthetic
strategy.
However,
selective
unstrained
still
one
most
challenging
projects
in
synthesis.
This
review
encompasses
strategies
employed
recent
years
for
cleavage
by
explicitly
focusing
on
their
applicability
functionalization.
expands
current
discourse
reactions
providing
comprehensive
overview
types
bonds.
includes
C-C(sp),
C-C(sp2),
C-C(sp3)
single
bonds;
double
triple
bonds,
focus
catalysis
transition
metals
organocatalysts.
Additionally,
specific
topics,
such
as
ring-opening
processes
involving
three-,
four-,
five-,
six-membered
rings,
are
discussed,
exemplar
applications
these
techniques
showcased
context
bioactive
molecules
discovery.
aims
shed
light
advancements
field
propose
potential
avenues
future
research
realm
