Catalytic conversion of mixed polyolefins under mild atmospheric pressure DOI Creative Commons

Binzhi Zhao,

Hui Tan,

Jie Yang

и другие.

The Innovation, Год журнала: 2024, Номер 5(2), С. 100586 - 100586

Опубликована: Фев. 3, 2024

The chemical recycling of polyolefin presents a considerable challenge, especially as upcycling methods struggle with the reality that plastic wastes typically consist mixtures polyethylene (PE), polystyrene (PS), and polypropylene (PP). We report catalytic aerobic oxidative approach for polyolefins corresponding carboxylic acids product. This method encompasses three key innovations. First, it operates under atmospheric pressure mild conditions, using O

Язык: Английский

Ring expansion of indene by photoredox-enabled functionalized carbon-atom insertion DOI
Fu‐Peng Wu, Chetan C. Chintawar, Rémy F. Lalisse

и другие.

Nature Catalysis, Год журнала: 2024, Номер 7(3), С. 242 - 251

Опубликована: Янв. 9, 2024

Язык: Английский

Процитировано

37
Dearomatization of Pyridines: Photochemical Skeletal Enlargement for the Synthesis of 1,2-Diazepines DOI

Elise Boudry,

Flavien Bourdreux,

Jérôme Marrot

и другие.

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(4), С. 2845 - 2854

Опубликована: Янв. 18, 2024

In this report, we developed a unified and standardized one-pot sequence that converts pyridine derivatives into 1,2-diazepines by inserting nitrogen atom. This skeletal transformation capitalizes on the in situ generation of 1-aminopyridinium ylides, which rearrange under UV light irradiation. A thorough evaluation key parameters (wavelength, reaction conditions, activating agent) allowed us to elaborate simple, mild, user-friendly protocol. The model was extrapolated more than 40 examples, including drug derivatives, affording unique 7-membered structures. Mechanistic evidence supports transient presence diazanorcaradiene species. Finally, pertinent transformations products, ring contraction reactions form pyrazoles, were conducted paved way broad application

Язык: Английский

Процитировано

34
Rational Molecular Editing: A New Paradigm in Drug Discovery DOI Creative Commons
Chunhua Ma, Craig W. Lindsley, Junbiao Chang

и другие.

Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(14), С. 11459 - 11466

Опубликована: Июнь 21, 2024

ADVERTISEMENT RETURN TO ARTICLES ASAPPREVEditorialNEXTRational Molecular Editing: A New Paradigm in Drug DiscoveryChunhua MaChunhua MaState Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, NMPA for Research and Evaluation Innovative Drug, School Chemistry Chemical Engineering, Henan Normal University, Xinxiang, 453007, ChinaMore by Chunhua Mahttps://orcid.org/0000-0001-7613-6471, Craig W. Lindsley*Craig LindsleyVanderbilt University Medical Center, Franklin, Tennessee 37027, United States*E-mail: [email protected]More Lindsleyhttps://orcid.org/0000-0003-0168-1445, Junbiao Chang*Junbiao ChangCollege Chemistry, State Zhengzhou 450001, China*E-mail: Chang, Bin Yu*Bin YuCollege Yuhttps://orcid.org/0000-0002-7207-643XCite this: J. Med. Chem. 2024, XXXX, XXX, XXX-XXXPublication Date (Web):June 21, 2024Publication History Received13 June 2024Published online21 2024https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c01347https://doi.org/10.1021/acs.jmedchem.4c01347editorialACS PublicationsPublished 2024 American Society. This publication is available under these Terms Use. Request reuse permissions free to access through this site. Learn MoreArticle Views-Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated reflect usage leading up last few days.Citations number other articles citing article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail (2 MB) Get e-AlertscloseSUBJECTS:Drug discovery,Macrocyclization,Molecules,Pharmaceuticals,Scaffolds e-Alerts

Язык: Английский

Процитировано

23
Regiodivergent Ring-Expansion of Oxindoles to Quinolinones DOI Creative Commons

Hendrik L. Schmitt,

Den Martymianov,

Ori Green

и другие.

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(7), С. 4301 - 4308

Опубликована: Фев. 9, 2024

The development of divergent methods to expedite structure–activity relationship studies is crucial streamline discovery processes. We developed a rare example regiodivergent ring expansion access two regioisomers from common starting material. To enable this regiodivergence, we identified distinct reaction conditions for transforming oxindoles into quinolinone isomers. presented proved be compatible with variety functional groups, which enabled the late-stage diversification bioactive as well facilitated synthesis drugs and their derivatives.

Язык: Английский

Процитировано

20
A deconstruction-reconstruction strategy for pyrimidine diversification DOI

Benjamin J. H. Uhlenbruck,

Celena M. Josephitis,

Louis de Lescure

и другие.

Nature, Год журнала: 2024, Номер 631(8019), С. 87 - 93

Опубликована: Май 2, 2024

Язык: Английский

Процитировано

19
Sulfenylnitrene-mediated nitrogen-atom insertion for late-stage skeletal editing of N -heterocycles DOI
Bidhan Ghosh,

Prakash Kafle,

Rishav Mukherjee

и другие.

Science, Год журнала: 2025, Номер 387(6729), С. 102 - 107

Опубликована: Янв. 2, 2025

Given the prevalence of nitrogen-containing heterocycles in commercial drugs, selectively incorporating a single nitrogen atom is promising scaffold hopping approach to enhance chemical diversity drug discovery libraries. We harness distinct reactivity sulfenylnitrenes, which insert transform readily available pyrroles, indoles, and imidazoles into synthetically challenging pyrimidines, quinazolines, triazines, respectively. Our additive-free method for skeletal editing employs easily accessible, benchtop-stable sulfenylnitrene precursors over broad temperature range (−30 150°C). This compatible with diverse functional groups, including oxidation-sensitive functionalities such as phenols thioethers, has been applied various natural products, amino acids, pharmaceuticals. Furthermore, we have conducted mechanistic studies explored regioselectivity outcomes through density theory calculations.

Язык: Английский

Процитировано

8
Diversification of Indoles and Pyrroles by Molecular Editing: New Frontiers in Heterocycle‐to‐Heterocycle Transmutation DOI

Fernanda Liu,

Lakshita Anand,

Michal Szostak

и другие.

Chemistry - A European Journal, Год журнала: 2023, Номер 29(24)

Опубликована: Фев. 2, 2023

Skeletal editing via single-atom insertion reactions involving nitrogen heterocycles have been reported by two innovative and complementary methods for the conversion of pyrroles indoles to pyridines, quinolines quinazolines. The use electrophilic carbonyl cation equivalents in situ generated nitrenes enables molecular transform forming foundation best-selling pharmaceuticals. Considering importance medicinal chemistry, biology natural products, these offer approach complex structures heterocycle diversification peripheral editing.

Язык: Английский

Процитировано

35
Rhodium-Catalyzed Intramolecular Nitrogen Atom Insertion into Arene Rings DOI

Hang Li,

Na Li, Jinghao Wu

и другие.

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(32), С. 17570 - 17576

Опубликована: Авг. 3, 2023

In this study, we describe the direct insertion of an intramolecular nitrogen atom into aromatic C–C bond. transformation, carbamoyl azides are activated by a Rh catalyst and subsequently directly inserted bond arene ring to access fused azepine products. This transformation is challenging, owing existence competitive C–H amination pathway. The use paddlewheel dirhodium complex Rh2(esp)2 effectively inhibited undesired insertion. Density functional theory calculations were performed reveal reaction mechanism origin chemoselectivity Rh-catalyzed reactions. novel products highly robust allow for downstream diversification.

Язык: Английский

Процитировано

33
Single-atom skeletal editing of 2H-indazoles enabled by difluorocarbene DOI
Yao Zhou,

F Chen,

Ziru Li

и другие.

Science China Chemistry, Год журнала: 2023, Номер 66(7), С. 1975 - 1981

Опубликована: Май 11, 2023

Язык: Английский

Процитировано

29
Late-stage modification of bioactive compounds: Improving druggability through efficient molecular editing DOI Creative Commons

Tongyu Huo,

Xin-Yi Zhao, Zengrui Cheng

и другие.

Acta Pharmaceutica Sinica B, Год журнала: 2023, Номер 14(3), С. 1030 - 1076

Опубликована: Ноя. 18, 2023

Synthetic chemistry plays an indispensable role in drug discovery, contributing to hit compounds identification, lead optimization, candidate drugs preparation, and so on. As Nobel Prize laureate James Black emphasized, "the most fruitful basis for the discovery of a new is start with old drug"

Язык: Английский

Процитировано

25