European Heart Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 19, 2025
Abstract
Backgrounds
and
Aims
Patients
with
periodontitis
(PD)
are
prone
to
developing
myocardial
infarction
(MI),
yet
the
prognosis
mechanisms
remain
unclear.
Given
presumed
close
association
of
neutrophils
both
conditions,
this
study
aims
elucidate
roles
in
mediating
interaction
between
PD
MI.
Methods
Three
prospective
cohorts
+
MI
mouse
model
were
investigated
assess
effects
on
prognosis.
Single-cell-RNA
sequencing
genome-wide
employed
identify
neutrophil
subtype
involved.
To
characterize
function
SiglecF+
neutrophils,
bone
marrow
transplantation,
Edu-pulse
chasing,
lineage
tracing,
collagen
contraction
assay
utilized.
Adoptive
transfer,
conditional
Siglecf
knockout
lipid
nanoparticles
facilitating
local
depletion
was
harnessed
explore
repair.
Results
Persisting
but
not
short-term
upset
(cardiac
fibrosis
function)
human
mice.
Bone
intrinsically
skewed
toward
longer-lived
differentiation,
a
that
converted
by
GMCSF
or
TGFβ
PPARγ-dependent
manner.
expanded
infarcted
heart
where
they
deposit
activate
fibroblasts
instigate
excessive
fibrosis.
efficacious
for
mitigating
Conclusions
This
demonstrated
long-lasting
PD-aggravated
expanding
scar-associated
into
highlighted
clinical
relevance
oral
health
examination
treating
holistic
fashion.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 22, 2025
Abstract
Black
phosphorus
(BP)
has
demonstrated
potential
as
a
drug
carrier
and
photothermal
agent
in
cancer
therapy;
however,
its
intrinsic
functions
treatment
remain
underexplored.
This
study
investigates
the
immunomodulatory
effects
of
polyethylene
glycol‐functionalized
BP
(BP‐PEG)
nanosheets
breast
models.
Using
immunocompetent
mouse
models‐including
4T1
orthotopic
BALB/c
mice
MMTV‐PyMT
transgenic
mice,
it
is
found
that
BP‐PEG
significantly
inhibits
tumor
growth
metastasis
without
directly
inducing
cytotoxicity
cells.
Mass
cytometry
analysis
reveals
reshapes
immune
microenvironment
by
recruiting
neutrophils.
Neutrophil
depletion
experiments
further
demonstrate
antitumor
are
dependent
on
Moreover,
bulk
single‐cell
RNA
sequencing
indicate
mainly
taken
up
macrophages,
leading
to
release
inflammatory
factors
such
IL1A
CXCL2,
which
enhance
neutrophil
recruitment
activation,
thereby
amplifying
response.
Finally,
co‐culture
assays
confirm
indeed
enhances
activity
neutrophils
natural
killer
(NK)
These
findings
position
an
capable
reprogramming
promote
innate
immunity
against
cancer.
By
stimulating
neutrophil‐mediated
activity,
offers
unique
therapeutic
approach
can
potentially
efficacy
existing
immunotherapies.
Biomarker Research,
Год журнала:
2025,
Номер
13(1)
Опубликована: Янв. 23, 2025
Neutrophil
extracellular
traps
(NETs)
are
intricate,
web-like
formations
composed
of
DNA,
histones,
and
antimicrobial
proteins,
released
by
neutrophils.
These
structures
participate
in
a
wide
array
physiological
pathological
activities,
including
immune
rheumatic
diseases
damage
to
target
organs.
Recently,
the
connection
between
NETs
cancer
has
garnered
significant
attention.
Within
tumor
microenvironment
metabolism,
exhibit
multifaceted
roles,
such
as
promoting
proliferation
migration
cells,
influencing
redox
balance,
triggering
angiogenesis,
driving
metabolic
reprogramming.
This
review
offers
comprehensive
analysis
link
emphasizing
areas
that
remain
underexplored.
include
interaction
with
mitochondria,
their
effect
on
states
within
tumors,
involvement
reprogramming,
contribution
angiogenesis
tumors.
Such
insights
lay
theoretical
foundation
for
deeper
understanding
role
development.
Moreover,
also
delves
into
potential
therapeutic
strategies
suggests
future
research
directions,
offering
new
perspectives
treatment
other
related
diseases.
European Heart Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 19, 2025
Abstract
Backgrounds
and
Aims
Patients
with
periodontitis
(PD)
are
prone
to
developing
myocardial
infarction
(MI),
yet
the
prognosis
mechanisms
remain
unclear.
Given
presumed
close
association
of
neutrophils
both
conditions,
this
study
aims
elucidate
roles
in
mediating
interaction
between
PD
MI.
Methods
Three
prospective
cohorts
+
MI
mouse
model
were
investigated
assess
effects
on
prognosis.
Single-cell-RNA
sequencing
genome-wide
employed
identify
neutrophil
subtype
involved.
To
characterize
function
SiglecF+
neutrophils,
bone
marrow
transplantation,
Edu-pulse
chasing,
lineage
tracing,
collagen
contraction
assay
utilized.
Adoptive
transfer,
conditional
Siglecf
knockout
lipid
nanoparticles
facilitating
local
depletion
was
harnessed
explore
repair.
Results
Persisting
but
not
short-term
upset
(cardiac
fibrosis
function)
human
mice.
Bone
intrinsically
skewed
toward
longer-lived
differentiation,
a
that
converted
by
GMCSF
or
TGFβ
PPARγ-dependent
manner.
expanded
infarcted
heart
where
they
deposit
activate
fibroblasts
instigate
excessive
fibrosis.
efficacious
for
mitigating
Conclusions
This
demonstrated
long-lasting
PD-aggravated
expanding
scar-associated
into
highlighted
clinical
relevance
oral
health
examination
treating
holistic
fashion.
