Pathogens,
Год журнала:
2024,
Номер
13(5), С. 388 - 388
Опубликована: Май 8, 2024
The
infection
by
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
is
associated
not
only
with
the
development
of
disease
but
also
long-term
symptoms
or
post-acute
sequelae
SARS-CoV-2
(PASC).
Multiple
lines
evidence
support
that
some
viral
antigens
and
RNA
can
persist
for
up
to
15
months
in
multiple
organs
body,
often
after
apparent
clearance
from
upper
system,
possibly
leading
persistence
symptoms.
Activation
immune
system
observed
a
prolonged
time,
providing
indirect
elements
infection.
In
gastrointestinal
tract,
could
stimulate
shaping
local
microbiota
potential
systemic
effects.
All
these
interactions
need
be
investigated,
taking
into
account
predisposing
factors,
multiplicity
pathogenic
mechanisms,
stratifying
populations
vulnerable
individuals,
particularly
women,
children,
immunocompromised
where
may
present
additional
challenges.
Nature Medicine,
Год журнала:
2024,
Номер
30(8), С. 2148 - 2164
Опубликована: Авг. 1, 2024
Long
COVID
represents
the
constellation
of
post-acute
and
long-term
health
effects
caused
by
SARS-CoV-2
infection;
it
is
a
complex,
multisystem
disorder
that
can
affect
nearly
every
organ
system
be
severely
disabling.
The
cumulative
global
incidence
long
around
400
million
individuals,
which
estimated
to
have
an
annual
economic
impact
approximately
$1
trillion-equivalent
about
1%
economy.
Several
mechanistic
pathways
are
implicated
in
COVID,
including
viral
persistence,
immune
dysregulation,
mitochondrial
dysfunction,
complement
endothelial
inflammation
microbiome
dysbiosis.
devastating
impacts
on
individual
lives
and,
due
its
complexity
prevalence,
also
has
major
ramifications
for
systems
economies,
even
threatening
progress
toward
achieving
Sustainable
Development
Goals.
Addressing
challenge
requires
ambitious
coordinated-but
so
far
absent-global
research
policy
response
strategy.
In
this
interdisciplinary
review,
we
provide
synthesis
state
scientific
evidence
assess
human
health,
systems,
economy
metrics,
forward-looking
roadmap.
Nature Immunology,
Год журнала:
2024,
Номер
25(4), С. 607 - 621
Опубликована: Апрель 1, 2024
One
in
ten
severe
acute
respiratory
syndrome
coronavirus
2
infections
result
prolonged
symptoms
termed
long
disease
(COVID),
yet
phenotypes
and
mechanisms
are
poorly
understood
Science Translational Medicine,
Год журнала:
2024,
Номер
16(754)
Опубликована: Июль 3, 2024
The
mechanisms
of
postacute
medical
conditions
and
unexplained
symptoms
after
SARS-CoV-2
infection
[Long
Covid
(LC)]
are
incompletely
understood.
There
is
growing
evidence
that
viral
persistence,
immune
dysregulation,
T
cell
dysfunction
may
play
major
roles.
We
performed
whole-body
positron
emission
tomography
imaging
in
a
well-characterized
cohort
24
participants
at
time
points
ranging
from
27
to
910
days
acute
using
the
radiopharmaceutical
agent
[
PLoS Medicine,
Год журнала:
2025,
Номер
22(1), С. e1004511 - e1004511
Опубликована: Янв. 23, 2025
Background
Self-reported
health
problems
following
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
infection
are
common
and
often
include
relatively
non-specific
complaints
such
as
fatigue,
exertional
dyspnoea,
concentration
or
memory
disturbance
sleep
problems.
The
long-term
prognosis
of
post-acute
sequelae
COVID-19/post-COVID-19
(PCS)
is
unknown,
data
finding
correlating
organ
dysfunction
pathology
with
self-reported
symptoms
in
patients
non-recovery
from
PCS
scarce.
We
wanted
to
describe
clinical
characteristics
diagnostic
findings
among
persisting
for
>1
year
assessed
risk
factors
persistence
versus
improvement.
Methods
This
nested
population-based
case-control
study
included
subjects
aged
18–65
years
(
n
=
982)
age-
sex-matched
control
without
576)
according
an
earlier
questionnaire
(6–12
months
after
infection,
phase
1)
consenting
provide
follow-up
information
undergo
comprehensive
outpatient
assessment,
including
neurocognitive,
cardiopulmonary
exercise,
laboratory
testing
four
university
centres
southwestern
Germany
(phase
2,
another
8.5
[median,
range
3–14
months]
1).
mean
age
the
participants
was
48
years,
65%
were
female.
At
67.6%
at
1
developed
persistent
PCS,
whereas
78.5%
recovered
remained
free
related
PCS.
Improvement
associated
mild
index
previous
full-time
employment,
educational
status,
no
specialist
consultation
not
attending
a
rehabilitation
programme.
development
new
initially
intercurrent
secondary
SARS-CoV-2
status.
Patients
less
frequently
never
smokers
(61.2%
75.7%),
more
obese
(30.2%
12.4%)
higher
values
body
mass
(BMI)
fat,
had
lower
status
(university
entrance
qualification
38.7%
61.5%)
than
continued
recovery.
Fatigue/exhaustion,
neurocognitive
disturbance,
chest
symptoms/breathlessness
anxiety/depression/sleep
predominant
symptom
clusters.
Exercise
intolerance
post-exertional
malaise
(PEM)
>14
h
compatible
myalgic
encephalomyelitis/chronic
fatigue
reported
by
35.6%
11.6%
patients,
respectively.
In
analyses
adjusted
sex-age
class
combinations,
centre
qualification,
significant
differences
between
those
recovery
observed
performance
three
different
tests,
scores
perceived
stress,
subjective
cognitive
disturbances,
dysautonomia,
depression
anxiety,
quality,
quality
life.
handgrip
strength
(40.2
[95%
confidence
interval
(CI)
[39.4,
41.1]]
42.5
CI
[41.5,
43.6]]
kg),
maximal
oxygen
consumption
(27.9
[27.3,
28.4]]
31.0
[30.3,
31.6]]
ml/min/kg
weight)
ventilatory
efficiency
(minute
ventilation/carbon
dioxide
production
slope,
28.8
[28.3,
29.2]]
27.1
[26.6,
27.7]])
significantly
reduced
relative
group
adjustment
centre,
education,
BMI,
smoking
use
beta
blocking
agents.
There
measures
systolic
diastolic
cardiac
function
rest,
level
N-terminal
brain
natriuretic
peptide
blood
levels
other
measurements
(including
complement
activity,
markers
Epstein–Barr
virus
[EBV]
reactivation,
inflammatory
coagulation
markers,
serum
cortisol,
adrenocorticotropic
hormone
dehydroepiandrosterone
sulfate).
Screening
viral
(PCR
stool
samples
spike
antigen
plasma)
subgroup
negative.
Sensitivity
(pre-existing
illness/comorbidity,
obesity,
medical
care
infection)
revealed
similar
findings.
PEM
pain
worse
results
almost
all
tests.
A
limitation
that
we
objective
on
exercise
capacity
cognition
before
infection.
addition,
did
unable
attend
clinic
whatever
reason
illness,
immobility
social
deprivation
exclusion.
Conclusions
this
study,
majority
working
recover
second
their
illness.
Patterns
essentially
similar,
dominated
complaints.
Despite
signs
deficits
capacity,
there
major
investigations,
our
do
support
persistence,
EBV
adrenal
insufficiency
increased
turnover
pathophysiologically
relevant
history
disease
might
help
stratify
cases
severity.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Май 31, 2024
Abstract
SARS-CoV-2
infections
worldwide
led
to
a
surge
in
cases
of
Long
COVID,
post-infectious
syndrome.
It
has
been
hypothesized
that
autoantibodies
play
crucial
role
the
development
COVID
and
other
syndromes,
such
as
fibromyalgia
myalgic
encephalomyelitis/chronic
fatigue
syndrome
(ME/CFS).
In
this
study,
we
tested
hypothesis
by
passively
transferring
total
IgG
from
patients
mice.
Using
Glial
Fibrillary
Acidic
Protein
(GFAP)
type-I
interferon
expression,
stratified
into
three
subgroups,
each
with
unique
plasma
proteome
signatures.
Remarkably,
transfer
two
which
are
characterized
higher
levels
neuronal
proteins
leukocyte
activation
markers,
induced
pronounced
persistent
sensory
hypersensitivity
distinct
kinetics.
Conversely,
third
subgroup,
enriched
skeletal
cardiac
muscle
profiles,
reduced
locomotor
activity
mice
without
affecting
their
motor
coordination.
These
findings
demonstrate
replicates
disease
symptoms,
underscoring
IgG’s
causative
pathogenesis.
This
work
proposes
murine
model
mirrors
COVID’s
pathophysiological
mechanisms,
may
be
used
tool
for
screening
developing
targeted
therapeutics.
Abstract
The
prevalence
of
many
chronic
noncommunicable
diseases
has
been
steadily
rising
over
the
past
six
decades.
During
this
time,
350,000
new
chemical
substances
have
introduced
to
lives
humans.
In
recent
years,
epithelial
barrier
theory
came
light
explaining
growing
and
exacerbations
these
worldwide.
It
attributes
their
onset
a
functionally
impaired
triggered
by
toxicity
exposed
substances,
associated
with
microbial
dysbiosis,
immune
system
activation,
inflammation.
Diseases
encompassed
share
common
features
such
as
an
increased
after
1960s
or
2000s
that
cannot
(solely)
be
accounted
for
emergence
improved
diagnostic
methods.
Other
traits
include
defects,
dysbiosis
loss
commensals
colonization
opportunistic
pathogens,
circulating
inflammatory
cells
cytokines.
addition,
practically
unrelated
fulfill
criteria
started
emerge
multimorbidities
during
last
Here,
we
provide
comprehensive
overview
discuss
evidence
similarities
epidemiology,
genetic
susceptibility,
dysfunction,
tissue
Angiogenesis,
Год журнала:
2024,
Номер
27(3), С. 293 - 310
Опубликована: Апрель 5, 2024
Abstract
In
European
countries,
nearly
10%
of
all
hospital
admissions
are
related
to
respiratory
diseases,
mainly
chronic
life-threatening
diseases
such
as
COPD,
pulmonary
hypertension,
IPF
or
lung
cancer.
The
contribution
blood
vessels
and
angiogenesis
regeneration,
remodeling
disease
progression
has
been
increasingly
appreciated.
vascular
supply
the
shows
peculiarity
dual
perfusion
circulation
(vasa
publica),
which
maintains
a
functional
blood-gas
barrier,
bronchial
privata),
reveals
profiled
capacity
for
(namely
intussusceptive
sprouting
angiogenesis)
alveolar-vascular
by
recruitment
endothelial
precursor
cells.
aim
this
review
is
outline
importance
in
variety
non-neoplastic
neoplastic
acute
infection,
fibrosis,
hypertension
