Brain Research, Год журнала: 2024, Номер unknown, С. 149286 - 149286
Опубликована: Окт. 1, 2024
Язык: Английский
Science, Год журнала: 2024, Номер 384(6698)
Опубликована: Май 23, 2024
The molecular organization of the human neocortex historically has been studied in context its histological layers. However, emerging spatial transcriptomic technologies have enabled unbiased identification transcriptionally defined domains that move beyond classic cytoarchitecture. We used Visium gene expression platform to generate a data-driven neuroanatomical atlas across anterior-posterior axis dorsolateral prefrontal cortex. Integration with paired single-nucleus RNA-sequencing data revealed distinct cell type compositions and cell-cell interactions domains. Using PsychENCODE publicly available data, we mapped enrichment types genes associated neuropsychiatric disorders discrete
Язык: Английский
Процитировано
23
JAMA Psychiatry, Год журнала: 2025, Номер unknown
Опубликована: Апрель 2, 2025
This Viewpoint discusses the opportunity to include inflammatory biomarkers as specifiers for major depression in upcoming Sixth Edition of Diagnostic and Statistical Manual Mental Disorders ( DSM-6 ).
Язык: Английский
Процитировано
2
Nature, Год журнала: 2025, Номер unknown
Опубликована: Апрель 23, 2025
Язык: Английский
Процитировано
2
Biology, Год журнала: 2025, Номер 14(1), С. 76 - 76
Опубликована: Янв. 15, 2025
Understanding the regulatory mechanisms of stress-induced immunosuppression and developing reliable diagnostic methods are important tasks in clinical medicine. This will allow for development effective strategies prevention treatment conditions associated with immune system dysfunction induced by chronic stress. The purpose this review is to conduct a comprehensive analysis synthesis existing data on immunosuppression. aimed at identifying key neuroendocrine, cytokine, cellular processes underlying suppression response under study involved search scientific literature covering cellular, molecular regulation, as well modern its diagnosis. Major international bibliographic databases publications biomedicine, psychophysiology, immunology were selected search. results identified regulating reviewed provided detailed descriptions neuroendocrine cytokine A significant portion confirms that activation hypothalamic-pituitary-adrenal (HPA) axis subsequent elevation cortisol levels exert substantial immunosuppressive effects cells, particularly macrophages lymphocytes, leading innate adaptive responses. also highlight crucial role catecholamines (adrenaline noradrenaline) initiating
Язык: Английский
Процитировано
1
Egyptian Journal of Medical Human Genetics, Год журнала: 2025, Номер 26(1)
Опубликована: Март 20, 2025
Abstract Background Posttraumatic stress disorder (PTSD) affects approximately 8% of the US population, with varying susceptibility among individuals exposed to trauma. While genetic factors contribute PTSD risk, emerging evidence suggests that epigenetic mechanisms play a crucial role in translating environmental exposures into lasting neurobiological changes. Purpose This review provides comprehensive analysis cutting-edge research on PTSD, particular emphasis novel findings regarding resilience and mechanisms. We explore recent technological advances their applications understanding pathophysiology. Main body Advanced epigenomic approaches have revealed complex interactions between DNA methylation, histone modifications, non-coding RNAs PTSD. Novel highlight cell type-specific signatures temporal dynamics following trauma exposure. Single-cell studies identified previously unknown cellular heterogeneity responses. Recent data modifications not only influence individual but may also transgenerational transmission effects. Integrative multi-omics new insights molecular networks underlying vulnerability. Conclusion unprecedented complexity These open avenues for personalized interventions based profiles suggest therapeutic strategies targeting modifications. enhanced has significant implications risk assessment, prevention, treatment. Graphical abstract
Язык: Английский
Процитировано
1
Biological Psychiatry, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
1
International Immunopharmacology, Год журнала: 2025, Номер 151, С. 114361 - 114361
Опубликована: Март 2, 2025
Язык: Английский
Процитировано
1
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Фев. 27, 2024
Abstract Pathophysiology of many neuropsychiatric disorders, including schizophrenia (SCZD), is linked to habenula (Hb) function. While pharmacotherapies and deep brain stimulation targeting the Hb are emerging as promising therapeutic treatments, little known about cell type-specific transcriptomic organization human or how it altered in SCZD. Here we define molecular neuroanatomy identify changes individuals with SCZD compared neurotypical controls. Utilizing Hb-enriched postmortem tissue, performed single nucleus RNA-sequencing (snRNA-seq; n=7 donors) identified 17 molecularly defined types across 16,437 nuclei, 3 medial 7 lateral populations, several which were conserved between rodents humans. Single molecule fluorescent situ hybridization (smFISH; n=3 validated snRNA-seq mapped their spatial locations. Bulk type deconvolution tissue from 35 33 controls yielded 45 SCZD-associated differentially expressed genes (DEGs, FDR < 0.05), 32 (71%) unique tissue. eQTL analysis 717 independent SNP-gene pairs (FDR where either SNP a risk variant (16 pairs) gene DEG (7 pairs). colocalization 16 colocalized genes. These results topographically organized distinct signatures demonstrate genetic associated SCZD, thereby providing novel insights into role disorders. One Sentence Summary Transcriptomic identification illness state.
Язык: Английский
Процитировано
4
Biological Psychiatry, Год журнала: 2024, Номер unknown
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
3
Biological Psychiatry Global Open Science, Год журнала: 2025, Номер 5(1), С. 100427 - 100427
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0