The gut microbiome modulate response to immunotherapy in cancer DOI
Shanshan Jiang,

Zi‐Ran Kang,

Yingxuan Chen

и другие.

Science China Life Sciences, Год журнала: 2024, Номер unknown

Опубликована: Сен. 2, 2024

Язык: Английский

Human organoids with an autologous tissue-resident immune compartment DOI Creative Commons
Timothy Recaldin, Linda Steinacher,

Bruno Gjeta

и другие.

Nature, Год журнала: 2024, Номер 633(8028), С. 165 - 173

Опубликована: Авг. 14, 2024

The intimate relationship between the epithelium and immune system is crucial for maintaining tissue homeostasis, with perturbations therein linked to autoimmune disease cancer

Язык: Английский

Процитировано

35
Gut microbiome and immune checkpoint inhibitor toxicity DOI Creative Commons
Rik J. Verheijden, Mick J M van Eijs, Fernanda L. Paganelli

и другие.

European Journal of Cancer, Год журнала: 2025, Номер 216, С. 115221 - 115221

Опубликована: Янв. 5, 2025

Язык: Английский

Процитировано

3
CTLA-4-expressing ILC3s restrain interleukin-23-mediated inflammation DOI

Anees Ahmed,

Ann Mary Joseph, Jordan Zhou

и другие.

Nature, Год журнала: 2024, Номер 630(8018), С. 976 - 983

Опубликована: Июнь 12, 2024

Язык: Английский

Процитировано

17
Novel strategies for modulating the gut microbiome for cancer therapy DOI
Young Seok Cho, Kai Han, Jin Xu

и другие.

Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 210, С. 115332 - 115332

Опубликована: Май 15, 2024

Язык: Английский

Процитировано

12
Crosstalk between gut microbiota and cancer immunotherapy: present investigations and future perspective DOI Creative Commons
Yuhui Tang,

Qiaoting Cai,

Zhi Tian

и другие.

Research, Год журнала: 2025, Номер 8

Опубликована: Янв. 1, 2025

Gut microbiota is crucial for protecting the homeostasis of immune locally and systemically, its dysbiosis essentially correlated to tumorigenesis, cancer progression, refractoriness treatments, including novel immunotherapy. Increasing evidence unravel intricate role gut in reshaping tumor microenvironment affecting efficacy toxicities immunotherapy, which shed more light on future applications efficacious biomarker combination treatment To better grasp underlying crosstalk between experimental clinical trials are indispensable customized microbiota-based treatments patients undergoing

Язык: Английский

Процитировано

1
The Gut Microbiota‐Xanthurenic Acid‐Aromatic Hydrocarbon Receptor Axis Mediates the Anticolitic Effects of Trilobatin DOI Creative Commons
Xiaoyu Wu,

Jiajia Wei,

Ran Wang

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

Abstract Current treatments for ulcerative colitis (UC) remain limited, highlighting the need novel therapeutic strategies. Trilobatin (TLB), a naturally derived food additive, exhibits potential anti‐inflammatory properties. In this study, dextran sulfate sodium (DSS)‐induced animal model is used to investigate effects of TLB on UC. It found significantly alleviates DSS‐induced UC in mice, as evidenced by reduction disease activity index, an increase colon length, improvement histopathological lesions. Furthermore, treatment results decrease proinflammatory cytokines and cytokines. mitigates modulating intestinal microbiota, particularly Akkermansia , which enhances tryptophan metabolism upregulates production xanthurenic acid (XANA). To confirm role TLB‐induced microbiota changes, experiments are performed with pseudogerm‐free mice fecal transplantation. also identified XANA key metabolite that mediates TLB's protective effects. Both markedly activate aromatic hydrocarbon receptor (AhR). Administration AhR antagonist abrogates their effects, thereby confirming involvement underlying mechanism. conclusion, study reveals mechanism through correcting imbalances, regulating metabolism, enhancing production, activating AhR.

Язык: Английский

Процитировано

1
Leveraging dirty mice that have microbial exposure to improve preclinical models of human immune status and disease DOI

Qian Liu,

Thames Pickett,

Deborah L. Hodge

и другие.

Nature Immunology, Год журнала: 2024, Номер 25(6), С. 947 - 950

Опубликована: Май 15, 2024

Язык: Английский

Процитировано

6
New dawn of ginsenosides: regulating gut microbiota to treat metabolic syndrome DOI
Xue Bai, Rongzhan Fu, Jianjun Deng

и другие.

Phytochemistry Reviews, Год журнала: 2024, Номер 23(4), С. 1247 - 1269

Опубликована: Фев. 16, 2024

Язык: Английский

Процитировано

4
Recent advances in understanding the immune microenvironment in ovarian cancer DOI Creative Commons
Jinxin Chen, Lu Yang, Yiming Ma

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июнь 5, 2024

The occurrence of ovarian cancer (OC) is a major factor in women’s mortality rates. Despite progress medical treatments, like new drugs targeting homologous recombination deficiency, survival rates for OC patients are still not ideal. tumor microenvironment (TME) includes cells, fibroblasts linked to (CAFs), immune-inflammatory and the substances these cells secrete, along with non-cellular components extracellular matrix (ECM). First, TME mainly plays role inhibiting growth protecting normal cell survival. As tumors progress, gradually becomes place promote progression. Immune have attracted much attention as targets immunotherapy. checkpoint inhibitor (ICI) therapy has potential regulate TME, suppressing factors that facilitate advancement, reactivating immune managing growth, extending advanced cancer. This review presents an outline current studies on distinct cellular elements within detailing their main functions possible signaling pathways. Additionally, we examine immunotherapy rechallenge OC, specific emphasis biological reasons behind resistance ICIs.

Язык: Английский

Процитировано

4
Integrating natural commensals and pathogens into preclinical mouse models DOI
Barbara Rehermann, Andrea L. Graham, David Masopust

и другие.

Nature reviews. Immunology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 19, 2024

Язык: Английский

Процитировано

4