International Journal of Environmental Research and Public Health,
Год журнала:
2024,
Номер
21(12), С. 1546 - 1546
Опубликована: Ноя. 22, 2024
The
gut
microbiota
plays
a
fundamental
role
in
the
host's
energy
metabolism
and
development
of
metabolic
diseases
such
as
arterial
hypertension,
insulin
resistance,
atherosclerosis.
Our
study
aimed
to
investigate
potential
hypertension
among
individuals
Kazakh
population
without
resistance.
16S
rRNA
gene
sequencing
faecal
samples
from
197
subjects
was
performed.
Preliminary
binary
comparisons
composition
depending
on
presence
resistance
revealed
statistically
significant
differences
abundance
The
polymorphic
microbiome
is
considered
a
new
hallmark
of
cancer.
Advances
in
High-Throughput
Sequencing
have
fostered
rapid
developments
research.
interaction
between
cancer
cells,
immune
and
microbiota
defined
as
the
immuno-oncology
(IOM)
axis.
Fungal
microbes
(the
mycobiome),
although
representing
only
∼
0.1-1%
microbiome,
are
critical
immunologically
active
component
tumor
microbiome.
Accumulating
evidence
suggests
possible
involvement
commensal
pathogenic
fungi
initiation,
progression,
treatment
responsiveness.
tumor-associated
mycobiome
mainly
consists
gut
mycobiome,
oral
intratumoral
mycobiome.
However,
role
remains
poorly
understood,
diversity
complexity
analytical
methods
make
it
challenging
to
access
this
field.
This
review
aims
elucidate
causal
complicit
roles
development
progression
while
highlighting
issues
that
need
be
addressed
executing
such
We
systematically
summarize
advantages
limitations
current
fungal
detection
analysis
methods.
enumerate
integrate
these
recent
findings
into
our
understanding
accompanied
by
prospect
novel
exhilarating
clinical
implications.
Environmental Microbiology,
Год журнала:
2025,
Номер
27(2)
Опубликована: Янв. 31, 2025
Corals
associate
with
a
diverse
community
of
prokaryotic
symbionts
that
provide
nutrition,
antioxidants
and
other
protective
compounds
to
their
host.
However,
the
influence
microbes
on
coral
thermotolerance
remains
understudied.
Here,
we
examined
microbial
communities
associated
colonies
Acropora
cf.
tenuis
exhibit
high
or
low
upon
exposure
33°C
(heated)
relative
29°C
(control).
Using
16S
rRNA
sequencing,
show
structure
all
A.
was
similar
each
at
control
temperature.
Thermotolerant
colonies,
however,
had
relatively
greater
abundance
Endozoicomonas,
Arcobacter,
Bifidobacterium
Lactobacillus.
At
elevated
temperature,
only
thermosensitive
showed
distinct
shift
in
microbiome,
an
increase
Flavobacteriales,
Rhodobacteraceae
Vibrio,
accompanying
marked
bleaching
response.
Functional
prediction
indicated
thermotolerant
corals
were
enriched
for
genes
related
metabolism,
while
microbiomes
cell
motility
antibiotic
compound
synthesis.
These
differences
may
contribute
variable
performance
under
thermal
stress.
Identification
taxa
correlated
provides
insights
into
beneficial
bacterial
groups
could
be
used
microbiome
engineering
support
reef
health
changing
climate.
Abstract
Root
exudates
are
important
mediators
of
plant–microbiome
interactions.
Recent
pioneering
studies
on
various
aerial
root
plants,
including
cereals,
have
shown
that
carbohydrate-rich
mucilage
can
enrich
diazotrophs
and
increase
host
nitrogen
utilization
growth.
Moreover,
non-diazotrophic
“gatekeeper”
microorganisms
in
help
defend
against
pathogenic
environmental
microbes.
These
findings
highlight
the
active
role
mediating
interactions
to
maintain
microbial
homeostasis
rhizosphere.
However,
little
is
known
about
specific
mechanisms
by
which
modulate
functional
microbiome
rhizosphere
microhabitats.
Here,
we
propose
typical
stable
biointeractions
four
plant–specific
mucilage–probiotic
systems
as
a
model
for
understanding
exudate–functional
interaction.
We
anticipate
this
provide
fundamental
biological
insights
into
Trends in Ecology & Evolution,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
All
species
host
a
rich
community
of
microbes.
This
microbiome
is
dynamic,
and
displays
seasonal,
daily,
even
hourly
changes,
but
also
needs
to
be
resilient
fulfill
important
roles
for
the
host.
In
evolutionary
ecology,
focus
dynamism
has
been
on
how
it
can
facilitate
adaptation
novel
environments.
However,
an
hitherto
largely
overlooked
issue
that
keep
its
in
check,
which
costly
leads
trade-offs
with
investing
other
fitness-related
traits.
Investigating
these
natural
vertebrate
systems
by
collecting
longitudinal
data
will
lead
deeper
insight
into
mechanisms
shape
host-microbiome
interactions.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(6), С. 2506 - 2506
Опубликована: Март 11, 2025
Staphylococcus
aureus-induced
mastitis
is
a
significant
cause
of
economic
losses
in
the
dairy
industry,
yet
its
molecular
mechanisms
remain
poorly
defined.
Although
ferroptosis,
regulated
cell
death
process,
associated
with
inflammatory
diseases,
role
bovine
unknown.
In
this
study,
11
S.
aureus
strains
were
isolated
from
milk
samples
obtained
cows
clinical
or
subclinical
mastitis.
Transcriptome
analysis
Mac-T
cells
challenged
identified
differentially
expressed
genes
(DEGs).
Enrichment
revealed
associations
between
DEG
clusters
and
traits
related
to
KEGG
pathway
enrichment
Toll-like
receptor,
TNF
signaling
as
significantly
enriched
pathways.
Weighted
gene
co-expression
network
(WGCNA)
further
prioritized
ferroptosis-related
(HMOX1,
SLC11A2,
STEAP3,
SAT1,
VDAC2)
involved
iron
metabolism.
Notably,
expression
levels
HMOX1
SAT1
increased
aureus-challenged
cells,
upregulation
was
consistent
trends
observed
transcriptome
data
mother–daughter
pairs
caused
by
infection.
Furthermore,
Ferrostatin-1
treatment
reduced
confirming
involvement
ferroptosis
process.
This
study
reveals
that
plays
key
highlights
potential
target
for
breeding
strategies
aimed
at
improving
resistance.
Brain Sciences,
Год журнала:
2025,
Номер
15(2), С. 195 - 195
Опубликована: Фев. 14, 2025
Most
brain
development
occurs
in
the
"first
1000
days",
a
critical
period
from
conception
to
child's
second
birthday.
Critical
processes
that
occur
during
this
time
include
synaptogenesis,
myelination,
neural
pruning,
and
formation
of
functioning
neuronal
circuits.
Perturbations
first
days
likely
contribute
later-life
neurodegenerative
disease,
including
sporadic
amyotrophic
lateral
sclerosis
(ALS).
Neurodevelopment
is
determined
by
many
events,
maturation
colonization
infant
microbiome
its
metabolites,
specifically
neurotransmitters,
immune
modulators,
vitamins,
short-chain
fatty
acids.
Successful
gut-brain
axis
function
depend
on
maternal
factors
(stress
exposure
toxins
pregnancy),
mode
delivery,
quality
postnatal
environment,
diet
after
weaning
breast
milk,
nutritional
deficiencies.
While
neonatal
highly
plastic,
it
remains
prone
dysbiosis
which,
once
established,
may
persist
into
adulthood,
thereby
inducing
chronic
inflammation
abnormal
excitatory/inhibitory
balance,
resulting
excitation.
Both
are
recognized
as
key
pathophysiological
ALS.