Metabolic Reprogramming in Gut Microbiota Exposed to Polystyrene Microplastics DOI Creative Commons

Jinhua Chi,

Jeffrey Patterson, Yan Jin

и другие.

Biomedicines, Год журнала: 2025, Номер 13(2), С. 446 - 446

Опубликована: Фев. 12, 2025

Background: Microplastics (MPs) are small plastic fragments with diameters less than 5 mm in size and prevalent everyday essentials consumables. Large global production has now led to a flooding of MPs our natural environment. Due their detrimental impacts on the planet's ecosystems potentially health, have emerged as significant public health concern. In this pilot study, we hypothesize that exposure will negatively affect gut microbiota composition function, which metabolic reprogramming plays an important role. Methods: Using vitro experiments, three bacterial strains (Escherichia coli MG1655, Nissle 1917, Lactobacillus rhamnosus) were selected investigate exposure. The individually cultured anaerobic chamber exposed 1 µm polystyrene at various concentrations (0, 10, 20, 50, 100, 500 µg/mL) culture medium. Results: reduced growth all dose-dependent manner. Liquid chromatography mass spectrometry (LC-MS)-based untargeted metabolomics revealed differences multiple pathways, such sulfur metabolism amino sugar nucleotide metabolism. addition, extracted from C57BL/6 mice, 16S rRNA sequencing results showed upregulation Lactobacillales reduction Erysipelotrichales due Furthermore, targeted corroborated alterations microbial tryptophan energy producing glycolysis/gluconeogenesis pentose phosphate pathway. Conclusions: These findings provide evidence causes comprehensive changes healthy microbiota, may also insights into mechanistic effects humans.

Язык: Английский

Self-Powered AlGaN/GaN HEMT-Based Sensor Integrated with Rotational TENG for Comprehensive Water Quality Analysis DOI
Manish Kumar Sharma,

Yen-Jui Lin,

Chia Kai Lin

и другие.

Nano Energy, Год журнала: 2025, Номер unknown, С. 110637 - 110637

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Micro/nanoplastics in aquaponic systems: sources, features and and their effects on the immune system of fish DOI

Linyong Zhi,

Zhen Li, Ruixue Li

и другие.

TrAC Trends in Analytical Chemistry, Год журнала: 2025, Номер unknown, С. 118158 - 118158

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Microplastics, Nanoplastics and Nanoparticles: Emerging Dynamic Carriers of Extracellular DNA Antibiotic Resistance Genes in the Environment DOI
Periyasamy Sivalingam, S. Farook Basha, Maheswaran Easwaran

и другие.

BioNanoScience, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 24, 2025

Язык: Английский

Процитировано

1
Effects of microplastics and salt single or combined stresses on growth and physiological responses of maize seedlings DOI
Xiaodong Liu,

Zongshuai Wang,

Guiyang Shi

и другие.

Physiologia Plantarum, Год журнала: 2025, Номер 177(1)

Опубликована: Янв. 1, 2025

Abstract Plastic film (mulch film) is widely used in saline and alkaline soils because it can effectively reduce salt stress damage. However, results the accumulation of microplastics (MPs) soil, which pose a threat to crop growth production. This study investigates effects 50 mg l −1 MPs 100 mM sodium chloride (NaCl), individually or combination, on physiological characteristics maize ( Zea mays ) seedlings. The demonstrated that compared control, NaCl single combined reduced seedling biomass water content, was more serious. Stress significantly N K contents leaves, Na content under lower than stress. Compared stress, further enhanced oxidative damage by increasing H 2 O MDA disrupted chloroplast structure, chlorophyll ultimately leading decline fluorescence parameters photosynthetic efficiency. Single led proline, soluble proteins, sugars, while stresses increased these osmotic substances plants. Moreover, activity CAT, POD, SOD AsA GsH. Collectively, exert notable toxic growth. Although inhibited showed antagonistic effects. These findings underscore importance assessing ecological risks posed

Язык: Английский

Процитировано

1
Metabolic Reprogramming in Gut Microbiota Exposed to Polystyrene Microplastics DOI Creative Commons

Jinhua Chi,

Jeffrey Patterson, Yan Jin

и другие.

Biomedicines, Год журнала: 2025, Номер 13(2), С. 446 - 446

Опубликована: Фев. 12, 2025

Background: Microplastics (MPs) are small plastic fragments with diameters less than 5 mm in size and prevalent everyday essentials consumables. Large global production has now led to a flooding of MPs our natural environment. Due their detrimental impacts on the planet's ecosystems potentially health, have emerged as significant public health concern. In this pilot study, we hypothesize that exposure will negatively affect gut microbiota composition function, which metabolic reprogramming plays an important role. Methods: Using vitro experiments, three bacterial strains (Escherichia coli MG1655, Nissle 1917, Lactobacillus rhamnosus) were selected investigate exposure. The individually cultured anaerobic chamber exposed 1 µm polystyrene at various concentrations (0, 10, 20, 50, 100, 500 µg/mL) culture medium. Results: reduced growth all dose-dependent manner. Liquid chromatography mass spectrometry (LC-MS)-based untargeted metabolomics revealed differences multiple pathways, such sulfur metabolism amino sugar nucleotide metabolism. addition, extracted from C57BL/6 mice, 16S rRNA sequencing results showed upregulation Lactobacillales reduction Erysipelotrichales due Furthermore, targeted corroborated alterations microbial tryptophan energy producing glycolysis/gluconeogenesis pentose phosphate pathway. Conclusions: These findings provide evidence causes comprehensive changes healthy microbiota, may also insights into mechanistic effects humans.

Язык: Английский

Процитировано

1