Advances in sleep research in 2024

The Lancet Neurology, Год журнала: 2024, Номер 24(1), С. 20 - 22

Опубликована: Дек. 18, 2024

Язык: Английский

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Calcineurin goes to sleep

Proceedings of the National Academy of Sciences, Год журнала: 2025, Номер 122(10)

Опубликована: Март 3, 2025

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microRNA-218-5p coordinates scaling of excitatory and inhibitory synapses during homeostatic synaptic plasticity

Proceedings of the National Academy of Sciences, Год журнала: 2025, Номер 122(14)

Опубликована: Апрель 2, 2025

Homeostatic synaptic plasticity (HSP) is a neuronal mechanism that allows networks to compensate for prolonged changes in activity by adjusting strength. This process crucial maintaining stable brain function and has been implicated memory consolidation during sleep. While scaling of both excitatory inhibitory synapses plays an important role homeostatic plasticity, molecules coordinating these processes are unknown. In this study, we investigate the miR-218-5p as regulator context picrotoxin (PTX)-induced downscaling (HSD) rat hippocampal neurons. Using enrichment analysis microRNA-binding sites genes changing upon PTX-induced HSD, bioinformatically predict experimentally validate increased PTX treatment. By electrophysiological recordings confocal microscopy, demonstrate inhibiting exerts dual effect HSD: It occludes dendritic spines, while at same time attenuating synapse upscaling. Furthermore, identify Neuroligin2 interacting molecule Mdga1 direct target which potentially mediates on upscaling synapses. performing long-term electroencephalographic recordings, further reveal local inhibition somatosensory cortex reduces slow-wave non-rapid-eye-movement summary, study uncovers key player Our findings contribute deeper understanding how neural circuits maintain stability face activity-induced perturbations, with implications pathophysiology.

Язык: Английский

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Prefrontal Cortex and the Control of Arousal States

Anesthesiology, Год журнала: 2025, Номер 142(5), С. 785 - 786

Опубликована: Апрель 8, 2025

Язык: Английский

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Sleep homeostasis in lizards and the role of the cortex

Proceedings of the National Academy of Sciences, Год журнала: 2025, Номер 122(16)

Опубликована: Апрель 17, 2025

Slow-wave sleep (SWS) and rapid eye movement are the two primary components of electrophysiological (e-sleep) in mammals birds. Slow waves cortex not only characterize SWS but also used as biological markers for homeostasis, given their rebound after deprivation (SD). Recently, it has been reported that Australian dragon Pogona vitticeps exhibits a two-stage pattern dorsal ventricular ridge (DVR), which includes homologue mammalian claustrum (CLA). It remains unclear whether reptilian e-sleep, characterized by activity outside cortex, compensates loss, observed mammals. We here report significant local field potential (LFP) 7 h SD. Meanwhile, mean bout length each state remained unaffected. further investigated possible role e-sleep regulation homeostasis found although corticotomy had no obvious effect on LFP features baseline sleep, abolished power CLA/DVR These findings suggest is common feature amniotes involved regulating rebounds reptiles

Язык: Английский

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Synaptic sleep pressure

Nature reviews. Neuroscience, Год журнала: 2024, Номер 25(12), С. 758 - 758

Опубликована: Окт. 17, 2024

Язык: Английский

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