Proceedings of the National Academy of Sciences,
Год журнала:
2024,
Номер
121(51)
Опубликована: Дек. 12, 2024
Nearly
every
cell
of
the
body
contains
a
circadian
clock
mechanism
that
is
synchronized
with
light-entrained
in
suprachiasmatic
nucleus
(SCN).
Desynchrony
between
SCN
and
external
environment
leads
to
metabolic
dysfunction
shift
workers.
Similarly,
mice
markedly
shortened
endogenous
period
due
deletion
REV-ERBα/β
nuclear
receptors
(SCN
DKO)
exhibit
increased
sensitivity
diet-induced
obesity
(DIO)
on
24
h
light:dark
cycle
while
REV-ERBs
deleted
hepatocytes
(HepDKO)
display
exacerbated
hepatosteatosis
response
high-fat
diet.
Here,
we
show
inducing
hepatocyte
DKO
(Hep-SCN
DDKO)
rescued
DIO
hepatic
triglyceride
accumulation,
without
affecting
behavioral
period.
These
findings
suggest
disturbances
environmental
desynchrony
central
are
effects
peripheral
clocks
which
can
be
mitigated
by
matching
periods
even
desynchronous
environment.
Thus,
maintaining
synchrony
within
an
organism,
rather
than
exogenous
clocks,
may
viable
target
for
treatment
disorders
associated
disruption.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 24, 2025
The
visceral
organ-brain
axis,
mediated
by
vagal
sensory
neurons,
is
essential
for
maintaining
various
physiological
functions.
Here,
we
investigate
the
impact
of
liver-projecting
neurons
on
energy
balance,
hepatic
steatosis,
and
anxiety-like
behavior
in
mice
under
obesogenic
conditions.
A
small
subset
innervate
liver
project
centrally
to
nucleus
tractus
solitarius,
area
postrema,
dorsal
motor
vagus,
peripherally
periportal
areas
liver.
loss
these
prevents
diet-induced
obesity,
outcomes
are
associated
with
increased
expenditure.
Although
males
females
exhibit
improved
glucose
homeostasis
following
disruption
only
male
display
insulin
sensitivity.
Furthermore,
limits
progression
steatosis.
Intriguingly,
lacking
liver-innervating
also
less
compared
control
mice.
Modulation
liver-brain
axis
may
aid
designing
effective
treatments
both
psychiatric
metabolic
disorders
obesity
MAFLD.
Liver-projecting
play
a
key
role
regulating
Modulating
via
vagus
nerve
offer
promising
therapeutic
approach
improving
lipid
metabolism,
homeostasis,
affective
diabetes.
Trends in Endocrinology and Metabolism,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Fasting
is
a
recurrent
daily
energy
stress
that
benefits
healthspan
and
lifespan.
While
ketones
fuel
fasting
in
vertebrates,
the
underlying
transcriptional
mechanism
remains
incompletely
understood.
Recently,
Korenfeld
et
al.
revealed
peroxisome
proliferator-activated
receptor
alpha
(PPARα)-dependent
enhancer
priming
as
keystone
for
ketone
production,
increasing
our
understanding
of
mechanisms
metabolic
alternate-day
(ADF).
npj Metabolic Health and Disease,
Год журнала:
2025,
Номер
3(1)
Опубликована: Апрель 9, 2025
Most
aspects
of
physiology
and
behaviour
fluctuate
every
24
h
in
mammals.
These
circadian
rhythms
are
orchestrated
by
an
autonomous
central
clock
located
the
suprachiasmatic
nuclei
that
coordinates
timing
cellular
clocks
tissues
throughout
body.
The
critical
role
this
system
is
emphasized
increasing
evidence
associating
disruption
with
diverse
pathologies.
Accordingly,
mounting
suggests
a
bidirectional
relationship
where
misalignment
may
contribute
to
liver
diseases
while
alter
other
tissues.
Therefore,
pathophysiology
broadly
impact
provide
mechanistic
framework
for
understanding
targeting
metabolic
adjust
setpoints.
Seminars in Liver Disease,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 16, 2025
The
nervous
system
plays
an
important
role
in
the
regulation
of
liver
functions
during
physiological
as
well
pathological
conditions.
This
regulatory
effect
is
based
on
processing
signals
transmitted
to
brain
by
sensory
nerves
innervating
tissue
and
other
visceral
organs
humoral
pathways
transmitting
from
peripheral
tissues
organs.
Based
these
signals,
modulates
metabolism,
detoxification,
regeneration,
repair,
inflammation,
processes
occurring
liver.
thus
determines
functional
morphological
characteristics
Liver
innervation
also
mediates
influence
psychosocial
factors
functions.
aim
this
review
describe
complexity
bidirectional
interactions
between
characterize
mechanisms
through
which
influences
function
conditions
maintains
systemic
homeostasis.
Poultry Science,
Год журнала:
2025,
Номер
104(7), С. 105255 - 105255
Опубликована: Май 3, 2025
In
modern
intensive
caged
laying
hen
production,
variations
in
egg-laying
time
(ELT)
among
layers
often
increase
the
workload
for
egg
collection,
thereby
raising
costs
of
labor
or
power
and
reducing
overall
efficiency.
For
management
purpose,
early
synchronized
ELT
is
also
advantageous,
particularly
to
large-scale
layer
farm.
However,
underlying
genetic
mechanisms
remain
unclear.
this
study,
through
development
video
artificial
intelligence-based
software,
records
during
peak
period
(27-32
weeks)
from
507
layers,
their
earlier
performance
(21-32
were
collected.
Via
whole
genome
sequencing
data
all
individuals,
estimated
heritabilities
traditional
production
traits
ranged
0.23
0.36,
consistent
with
previous
reports.
The
heritability
average
(AELT)
was
as
0.46.
Furthermore,
individuals
AELT
tended
exhibit
superior
performance.
Genome-wide
association
study
revealed
three
SNPs
associated
traits,
located
at
170,867,650
bp
on
chromosome
1,
5,548,087
5,817,488
9.
Across
region
5.4
7.0
Mb
9,
mutations
identified
be
strongly
linked
two
AELT-associated
SNPs.
Genes
may
responsible
differences
hens.
These
results
indicate
that
has
potential
integrated
into
system
layers.
If
included
a
breeding
objective
future,
its
reliability
needs
validated
larger
populations
over
longer
periods.
Journal of Neuroscience Research,
Год журнала:
2025,
Номер
103(5)
Опубликована: Май 1, 2025
ABSTRACT
The
vagus
nerve,
serving
as
a
pivotal
link
between
the
brain
and
vital
organs,
regulates
crucial
physiological
functions.
It
plays
central
role
in
maintaining
homeostasis
within
body
must
dynamically
adapt
to
changing
conditions
such
anesthesia
or
sleep.
While
vagal
tone,
typically
estimated
indirectly
from
heart
rate
variability,
has
been
extensively
studied,
direct
measurement
of
activity
during
sleep
remains
unreported
date.
Recent
technological
advancements
have
facilitated
recording
nerve
freely
moving
rodents
using
small,
highly
flexible
carbon
nanotube
yarns.
Consequently,
it
is
now
feasible
directly
investigate
events
known
impact
homeostasis,
diurnal
variations
anesthesia.
In
this
study,
we
explore
relationship
by
comparing
effects
2%
isoflurane
with
male
Sprague
Dawley
rats.
findings
reveal
that
significantly
suppresses
activity,
normal
levels
do
not
resume
until
2
h
after
termination
supply.
Additionally,
examine
influence
on
observe
notable
presence
patterns.
These
results
provide
insights
into
interaction
among
anesthesia,
variations,
offering
valuable
understanding
autonomic
nervous
system
critical
states.
