Regulation of cellular senescence in tumor progression and therapeutic targeting: mechanisms and pathways

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Апрель 2, 2025

Cellular senescence, a stable state of cell cycle arrest induced by various stressors or genomic damage, is recognized as hallmark cancer. It exerts context-dependent dual role in cancer initiation and progression, functioning tumor suppressor promoter. The complexity senescence arises from its mechanistic diversity, potential reversibility, heterogeneity. A key mediator these effects the senescence-associated secretory phenotype (SASP), repertoire bioactive molecules that influence microenvironment (TME) remodeling, modulate behavior, contribute to therapeutic resistance. Given intricate biology, presents both challenges opportunities for intervention. Strategies targeting pathways, including senescence-inducing therapies senolytic approaches, offer promising avenues treatment. This review provides comprehensive analysis regulatory mechanisms governing cellular tumors. We also discuss emerging strategies highlighting novel opportunities. deeper understanding processes essential developing precision improving clinical outcomes.

Язык: Английский

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Everything everywhere all at once: Unraveling the waves of aging

Immunity, Год журнала: 2025, Номер 58(2), С. 276 - 278

Опубликована: Фев. 1, 2025

Язык: Английский

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Rejuvenation of Bone Marrow Mesenchymal Stem Cells: Mechanisms and Their Application in Senile Osteoporosis Treatment

Biomolecules, Год журнала: 2025, Номер 15(2), С. 276 - 276

Опубликована: Фев. 13, 2025

Bone marrow mesenchymal stromal cells (BM-MSCs) are multipotent present in bone marrow; they play a crucial role the process of formation. Cellular senescence is defined as stable state cell cycle arrest that impairs functioning cells. Research has shown aging triggers BM-MSCs, leading to reduced capacity for osteogenic differentiation and accumulation senescent cells, which can accelerate onset various diseases. Therefore, it essential explore mechanisms strategies rejuvenation BM-MSCs. Senile osteoporosis (SOP) metabolic disease characterized by The BM-MSCs considered one most important factors occurrence development SOP. treatment SOP represents promising strategy. This work provides summary functional alterations observed systematic review facilitate Additionally, we analyze progress limitations associated with application rejuvenated treat SOP, aim providing new insights prevention

Язык: Английский

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A subtype of T cells impedes tissue repair in aged spinal cord after injury

Neuron, Год журнала: 2025, Номер 113(5), С. 643 - 645

Опубликована: Март 1, 2025

Язык: Английский

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Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions

Cell, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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PanSci: decoding panoramas of ageing

Science China Life Sciences, Год журнала: 2025, Номер unknown

Опубликована: Апрель 23, 2025

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