Mental exploration of future choices during immobility theta oscillations

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

SUMMARY Mental exploration enables flexible evaluation of potential future choices, guiding decision-making without requiring direct real-world iterations. Although the hippocampus is known to be active while imagining future, precise mechanisms that support mental choices remain unclear. In hippocampus, theta rhythm (4-12 Hz) prevalent during movement and supports memory coding by organizing neuronal activity patterns into short virtual path segments (theta sequences) around rat’s location. We observed these theta-related neural in a hippocampus-dependent working task also, unexpectedly, oscillations immobility. Compared standard sequences movement, immobility differed they occurred at shifted phase preferentially represented remote locations, particular next choice task. Coding for locations was also awake sharp wave ripple, but short-lasting events rarely were biased toward frequently visited locations. Therefore, our findings suggest recurring bouts immobility, which are primates humans, cognitive demands hippocampal network facilitate ongoing predictions choices.

Язык: Английский

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Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy

Cell Reports, Год журнала: 2025, Номер 44(2), С. 115131 - 115131

Опубликована: Янв. 22, 2025

Язык: Английский

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Self-sustained and oscillatory activity in two types of attractor networks

Nonlinear Dynamics, Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

Язык: Английский

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Intrinsic and circuit mechanisms of predictive coding in a grid cell network model

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 17, 2025

Abstract Grid cells in the medial entorhinal cortex (MEC) fire when an animal is located at vertices of a hexagonal grid that extends across environment. The population activity serves as allocentric representation current location animal. Recent studies have identified class represent locations ahead How do these predictive representations emerge from wetware MEC? To address this question, we developed detailed conductance-based model MEC network, constrained by existing data on biophysical properties stellate and topology network. Our revealed two mechanisms underlying emergence code MEC. first relied time scale associated with HCN conductance. other depended degree asymmetry former mechanism was sufficient to explain coding layer II represented shifted location. shift equivalent ~5% diameter field. latter required III were forward distance ~25% A corollary our model, extent changes monotonically along dorsoventral axis following observed conductance, borne out recent experiments.

Язык: Английский

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Object-translocation induces event coding in the rat hippocampus

Communications Biology, Год журнала: 2025, Номер 8(1)

Опубликована: Май 24, 2025

Episodic memory is the ability to recall personally experienced events that are situated within specific spatial contexts. Within a navigation environment, salient objects can function as landmarks, and interactions with them be encoded distinct episodic events. However, nuanced integration of "where" "what" aspects during formation remains poorly understood. In this study, we conduct comprehensive analysis neuronal responses along rat CA1 proximodistal axis manipulations environmental cues object features. Our results demonstrate proximal distal portions preferentially represent landmarks events, respectively. Following displacement, identify an event-like population coding CA1, from anticipated pattern landmark representation. These findings elucidate roles may play in encoding, providing novel insights into selective processing object-related information entorhinal-hippocampal network under varying conditions.

Язык: Английский

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Mapping future locations

Nature reviews. Neuroscience, Год журнала: 2024, Номер 25(10), С. 646 - 646

Опубликована: Сен. 2, 2024

Язык: Английский

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