Exploring the untapped potential of single‐cell and spatial omics in plant biology

New Phytologist, Год журнала: 2025, Номер unknown

Опубликована: Май 21, 2025

Summary Advances in single‐cell and spatial omics technologies have revolutionised biology by revealing the diverse molecular states of individual cells their organization within tissues. The field plant has widely adopted transcriptome chromatin accessibility profiling transcriptomics, which extend traditional cell genomics analyses provide unique opportunities to reveal cellular dynamics Using these technologies, comprehensive atlases been generated several model species, providing valuable platforms for discovery tool development. Other emerging related omics, such as multiomics, lineage tracing, recording, high‐content genetic chemical perturbation phenotyping, offer immense potential deepening our understanding yet remain underutilised due technical challenges resource availability. Overcoming plant‐specific barriers, wall complexity limited antibody resources, alongside community‐driven efforts developing more complete reference computational tools, will accelerate progress. synergy between technological innovation targeted biological questions is poised drive significant discoveries, advancing science. This review highlights current applications research introduces approaches with transform field.

Язык: Английский

High-resolution imaging of RNA and proteins in thick tissues using cycleHCR

Nature Reviews Genetics, Год журнала: 2025, Номер unknown

Опубликована: Май 28, 2025

Язык: Английский