Spatial multi-omic map of human myocardial infarction

Nature, Год журнала: 2022, Номер 608(7924), С. 766 - 777

Опубликована: Авг. 10, 2022

Язык: Английский

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Biology of lung macrophages in health and disease

Immunity, Год журнала: 2022, Номер 55(9), С. 1564 - 1580

Опубликована: Сен. 1, 2022

Язык: Английский

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Tissue-specific macrophages: how they develop and choreograph tissue biology

Nature reviews. Immunology, Год журнала: 2023, Номер 23(9), С. 563 - 579

Опубликована: Март 15, 2023

Macrophages are innate immune cells that form a 3D network in all our tissues, where they phagocytose dying and cell debris, complexes, bacteria other waste products. Simultaneously, produce growth factors signalling molecules — such activities not only promote host protection response to invading microorganisms but also crucial for organ development homeostasis. There is mounting evidence of macrophages orchestrating fundamental physiological processes, as blood vessel formation, adipogenesis, metabolism central peripheral neuronal function. In parallel, novel methodologies have led the characterization tissue-specific macrophages, with distinct subpopulations these showing different developmental trajectories, transcriptional programmes life cycles. Here, we summarize growing knowledge macrophage diversity how subsets orchestrate tissue We further interrelate ontogeny their core functions across is, events within niche may control functionality during development, homeostasis ageing. Finally, highlight open questions will need be addressed by future studies better understand subsets. important immunity infections clearing products from maintain health regulating metabolism, many biological processes. Elvira Mass co-workers discuss populations found throughout body, highlighting shared unique aspects functions.

Язык: Английский

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Physiology and diseases of tissue-resident macrophages

Nature, Год журнала: 2023, Номер 618(7966), С. 698 - 707

Опубликована: Июнь 21, 2023

Язык: Английский

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Mapping the developing human immune system across organs

Science, Год журнала: 2022, Номер 376(6597)

Опубликована: Май 12, 2022

Single-cell genomics studies have decoded the immune cell composition of several human prenatal organs but were limited in describing developing system as a distributed network across tissues. We profiled nine tissues combining single-cell RNA sequencing, antigen-receptor and spatial transcriptomics to reconstruct system. This revealed late acquisition immune-effector functions by myeloid lymphoid subsets maturation monocytes T cells before peripheral tissue seeding. Moreover, we uncovered system-wide blood development beyond primary hematopoietic organs, characterized B1 cells, shed light on origin unconventional cells. Our atlas provides both valuable data resources biological insights that will facilitate engineering, regenerative medicine, disease understanding.

Язык: Английский

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Spatially resolved multiomics of human cardiac niches

Nature, Год журнала: 2023, Номер 619(7971), С. 801 - 810

Опубликована: Июль 12, 2023

The function of a cell is defined by its intrinsic characteristics and niche: the tissue microenvironment in which it dwells. Here we combine single-cell spatial transcriptomics data to discover cellular niches within eight regions human heart. We map cells microanatomical locations integrate knowledge-based unsupervised structural annotations. also profile cardiac conduction system

Язык: Английский

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Therapeutic targeting of tumour myeloid cells

Nature reviews. Cancer, Год журнала: 2023, Номер 23(4), С. 216 - 237

Опубликована: Фев. 6, 2023

Язык: Английский

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Integrated single-cell analysis-based classification of vascular mononuclear phagocytes in mouse and human atherosclerosis

Cardiovascular Research, Год журнала: 2022, Номер 119(8), С. 1676 - 1689

Опубликована: Окт. 3, 2022

Accumulation of mononuclear phagocytes [monocytes, macrophages, and dendritic cells (DCs)] in the vessel wall is a hallmark atherosclerosis. Using integrated single-cell analysis mouse human atherosclerosis, we here aimed to refine nomenclature atherosclerotic vessels compare their transcriptomic profiles disease.

Язык: Английский

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Macrophage phenotypes and functions: resolving inflammation and restoring homeostasis

Trends in Immunology, Год журнала: 2023, Номер 44(12), С. 986 - 998

Опубликована: Ноя. 6, 2023

Язык: Английский

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Resident cardiac macrophages: Heterogeneity and function in health and disease

Immunity, Год журнала: 2022, Номер 55(9), С. 1549 - 1563

Опубликована: Сен. 1, 2022

Язык: Английский

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